A5064189236- Physics of Superconductivity and Magnetism
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Advanced Proteomics Techniques and Applications
- Acoustic Wave Resonator Technologies
- Polymer Nanocomposites and Properties
- Mass Spectrometry Techniques and Applications
- Iron-based superconductors research
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Frequency and Time Standards
- Glycosylation and Glycoproteins Research
- CRISPR and Genetic Engineering
- Superconductivity in MgB2 and Alloys
- Pickering emulsions and particle stabilization
- Polymer Surface Interaction Studies
- Graphene and Nanomaterials Applications
- Covalent Organic Framework Applications
- Bone Tissue Engineering Materials
- Advanced Battery Technologies Research
- Advancements in Battery Materials
- Biosensors and Analytical Detection
- Advanced Battery Materials and Technologies
- Microwave Engineering and Waveguides
- Extracellular vesicles in disease
- Advanced Electrical Measurement Techniques
Sichuan University
2016-2025
Shanxi Agricultural University
2025
Tongji University
2018-2025
China National Petroleum Corporation (China)
2025
Guangxi University
2010-2024
The University of Sydney
2024
Guangxi University of Chinese Medicine
2024
Huizhou Central People's Hospital
2024
Huainan Union University
2024
University of South China
2020-2024
The beneficial effect of magnetic scaffolds on the improvement cell proliferation has been well documented. Nevertheless, underlying mechanisms about stimulating remain largely unknown. Once scaffold enters into biological fluids, a protein corona forms and directly influences function scaffold. This study aimed at investigating formation coronas hydroxyapatite (HA) (MHA) in vitro vivo, consequently its regulating proliferation. results demonstrated that nanoparticles (MNP)-infiltrated HA...
To date, abundant strategies and affinity materials are proposed to enrich phosphopeptides glycopeptides from biological systems. However, few can meet the demand for enriching both with an integrated single material. In this work, a novel magnetic metal–organic framework nanocomposite Zr4+ ions as metal unit well terephthalic acid (PTA) 1,4-phenylenebisboronic (denoted PBA) dual organic ligands was designed fabricated highly efficient enrichment of glycopeptides. It is worth mentioning that...
Host–guest interactions involved immunoaffinity superparamagnetic nanoparticles for fast, high-efficiency and high-purity exosome isolation elution.
Abstract It is challenging to detect and differentiate multiple diseases with high complexity/similarity from the same organ. Metabolic analysis based on nanomatrix‐assisted laser desorption/ionization mass spectrometry (NMALDI‐MS) a promising platform for disease diagnosis, while enhanced property of its core nanomatrix materials has plenty room improvement. Herein, multidimensional interactive cascade nanochip composed iron oxide nanoparticles (FeNPs)/MXene/gold (AuNPs), IMG, reported...
Abstract The free‐to‐total prostate‐specific antigen (f/t‐PSA) ratio is of great significance in the accurate diagnosis prostate cancer. Herein, a smartphone‐based detection system reported using colorimetric reaction integrated with proximity‐induced bio‐barcode and clustered regularly interspaced short palindromic repeats (CRISPR)/Cas12a assay for f/t‐PSA detection. DNA/antibody recognition probes are designed to bind f‐PSA or t‐PSA induce release DNA bio‐barcode. CRISPR/Cas12a activated...
Rapid and accurate detection plays a critical role in improving the survival prognosis of patients with cardiovascular disease, but traditional methods are far from ideal for those suspected conditions. Metabolite analysis based on nanomatrix-assisted laser desorption/ionization mass spectrometry (NMALDI-MS) is considered to be promising technique disease diagnosis. However, performance core nanomatrixes has limited its clinical application. In this study, we constructed 3D flower-shaped...
Abstract This work, for the first time, investigated diversity of endophytic fungi harbored in xylem and phloem root Sophora tonkinensis Gapnep from three geographic localities with emphasis on influence tissue type locality fungal communities their potential as biocontrol agents against phytopathogens Panax notoginseng . A total 655 strains representing 47 taxa were isolated. Forty‐two (89.4%) identified but not five (10.6%) according to morphology molecular phylogenetics. Out identifiable...
Abstract Global DNA hypomethylation is a most common epigenetic alteration in cancer, but the mechanism remains elusive. Previous studies demonstrate that UHRF1 not UHRF2 required for mediating maintenance methylation by DNMT1. Here we report unexpectedly conserved function and UHRF2: inhibiting de novo functioning as E3 ligases promoting DNMT3A degradation. UHRF1/2 are frequently overexpressed cancers present evidence overexpression downregulates proteins consequently leads to...
Endogenous glycopeptides have been confirmed to play a significant role in multifarious pathological and physiological processes. The low abundance of endogenous abundant interferents (e.g., large-size proteins heteropeptides) complex biological matrices render the direct analysis difficult. Reported here is novel glutathione-functionalized magnetic covalent organic framework microsphere (denoted as MCNC@COF@GSH) endowed with size-exclusion effect strong hydrophilicity for selective...
Magnetic guanidyl-functionalized metal–organic framework (MOF) nanospheres with multi-affinity sites (inherent Zn–O cluster, amino group, and guanidyl group) for efficient enrichment of global phosphopeptides.
Abstract Downstream studies of circulating tumor cells (CTCs), which may provide indicative evaluation information for therapeutic efficacy, cancer metastases, and prognosis, are seriously hindered by the poor purity enriched CTCs as large amounts interfering leukocytes still nonspecifically bind to isolation platform. In this work, biomimetic immunomagnetic nanoparticles (BIMNs) with following features designed: i) leukocyte membrane camouflage, could greatly reduce homologous interaction...
Bladder cancer (BCa) is one of the most common malignancies affecting men.Oncogenic transcription factors function as an important regulator in progression human cancer.In our study, we aimed to construct artificial circular non-coding RNAs (acircRNAs) consisting three functional units that mimic CRISPR-Cas system and elucidate its therapeutic role bladder cancer.Additionally, compare efficiency regulating gene expression between acircRNA CRISPR-dCas systems was performed.We connected cDNA...
Mirror-like Tl2Ba2CaCu2O8 thin films have been reproducibly prepared on (001)LaAlO3 substrates by dc magnetron sputtering using 80% argon and 20% oxygen post-annealing at temperatures of 720–760 °C in 1 atm pure argon. X-ray diffraction patterns θ-2θ scans, φ Read camera photographs prove that the are strongly textured with c-axis perpendicular to substrate surfaces epitaxially grown Tl2Ba2CaCu2O8(100) parallel LaAlO3(100). The zero resistance range 105.2–108.6 K for 0.2–1.0-μm-thick films....
Abstract Limited core transcription factors and transcriptional cofactors have been shown to govern embryonic stem cell (ESC) circuitry pluripotency, but the molecular interactions between remains ill defined. Here, we analyzed protein–protein Oct4, Sox2, Klf4, Myc (abbreviated as OSKM) a large panel of cofactors. The data reveal both specific common OSKM We found that among SET1/MLL family H3K4 methyltransferases, Set1a specifically interacts with Oct4 this interaction is independent Wdr5....
Novel magnetic metal–organic framework nanocomposites with 1,4-phenylenebisboronic acid as both an organic ligand and a functional molecule are proposed for the first time new type of intelligent nanomaterial to selectively capture release glycoproteins via pH-stimulus-response, would be great potential use in bio-separation.
Highly specific enrichment of phosphopeptides from complex biological samples was a precondition for further studying its physiological and pathological processes due to the important trace amounts phosphopeptides. In this work, phytic acid (PA) functionalized magnetic cerium zirconium bimetallic metal-organic framework nanocomposites (denoted as Fe3O4@SiO2@Ce-Zr-MOF@PA) were fabricated by facile yet efficient method. The as-prepared nanomaterial exhibited high sensitivity (0.1 fmol μL-1),...