A5005066058- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- Dendrimers and Hyperbranched Polymers
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Polymer Surface Interaction Studies
- Advanced Polymer Synthesis and Characterization
- Gold and Silver Nanoparticles Synthesis and Applications
- Microfluidic and Bio-sensing Technologies
- Pickering emulsions and particle stabilization
- Graphene and Nanomaterials Applications
- Cancer Research and Treatments
- Molecular Communication and Nanonetworks
- Solar-Powered Water Purification Methods
- Cancer Genomics and Diagnostics
- Supramolecular Self-Assembly in Materials
- Lattice Boltzmann Simulation Studies
- Supramolecular Chemistry and Complexes
- biodegradable polymer synthesis and properties
- Cell Adhesion Molecules Research
- Wound Healing and Treatments
- Proteoglycans and glycosaminoglycans research
- Antimicrobial Peptides and Activities
Sichuan University
2016-2025
Chengdu University
2014-2021
Queen Mary University of London
2012-2013
North Sichuan Medical University
2011
Materials Science & Engineering
2006
Host–guest interactions involved immunoaffinity superparamagnetic nanoparticles for fast, high-efficiency and high-purity exosome isolation elution.
The light-up magnetic aptamer-sensor Fe<sub>3</sub>O<sub>4</sub>@Au for ultra-sensitive lung cancer exosome detection based on fluorescence resonance energy transfer.
Abstract Downstream studies of circulating tumor cells (CTCs), which may provide indicative evaluation information for therapeutic efficacy, cancer metastases, and prognosis, are seriously hindered by the poor purity enriched CTCs as large amounts interfering leukocytes still nonspecifically bind to isolation platform. In this work, biomimetic immunomagnetic nanoparticles (BIMNs) with following features designed: i) leukocyte membrane camouflage, could greatly reduce homologous interaction...
The rapid development of exosome research provides new insights into the physiological role exosomes and their significant correlation with human health. Although derived from tumor sources have been proven to be promising biomarkers for cancer detection disease progression due inherited biological contents parent cells unique roles in metastasis invasion, it is still a challenging task perform effective isolation complex samples conduct high-precision real-time analysis. Herein, we propose...
UV responsive microcapsules containing azobenzene were fabricated by sequential deposition of oppositely charged poly[1-[4-(3-carboxy-4-hydroxyphenylazo)benzenesulfonamido]-1,2-ethanediyl, sodium salt] (PAZO) and poly(diallyldimethyl ammonium) chloride (PDADMAC). As found in this work, combination PDADMAC PAZO led to aggregation segments the progress polymer deposition, which facilitated large extent J aggregates when capsules exposed light. aggregate assemblies destroyed integrity capsule...
In this work, we presented ternary nanoparticles [poly(carboxybetaine methacrylate) (pCBMA)(peptide dendrimer-modified carbon dots (CD-D)/doxorubicin (DOX))] based on peptide dendritic (CDs) to realize tumor-specific drug delivery and highly efficient cancer therapy. The versatile could achieve "stealth" in blood due the antifouling zwitterion coating. Meanwhile, charge changes of zwitterions be moderated during their transportation toward/inside tumor cells, where subtle environmental pH...
The enrichment performance of immunomagnetic beads (IMBs) in blood samples is usually challenging due to the ungoverned, situ-formed protein corona, as it generally leads negative effects, such impeded targeting capacity and unwanted nonspecific absorption. On contrary, a controlled premodification IMBs with diverse functional environment (blood) proteins endows composites new biological identity may improve anti-nonspecific ability, resulting promising isolation benefits for circulating...
Abstract The capture of melanoma circulating tumor cells (melanoma CTCs, MelCTCs) is great significance for the early diagnosis and personalized treatment melanoma. rarity heterogeneity MelCTCs have greatly limited development methods, especially those based on immune/aptamer‐affinity. Herein, an extracellular vesicles‐camouflaged strategy designed to functionalize magnetic nanoparticles (Fe 3 O 4 ) generate vesicles @lip/ev) with excellent antifouling active cell targeting properties....
Fluorescence sensing is widely used in vitro detection due to its high sensitivity and rapid result delivery. However, systems based on nanomaterials involving complex cumbersome purification steps can lead sample loss significantly reduce the accuracy of results. To address this issue, we proposed a lanthanide-based aptasensor featuring target-triggered antenna effect enhance time-resolved luminescence (TRL) chelated Tb3+ combined with wash-free strategy. This sensor enabled highly...
By introducing UV-sensitive chemical groups causing different potential response as building blocks, fabricated LbL capsules can be endowed with dual UV-responsive properties in specific layers. One block is responsible for fast capsule sealing and the other longer term swelling rupture. Therefore, multifunction of these could activated selectively when exposed to external UV light suitable wavelengths. In this work, dual-functional complex microcapsules (PDADMAC/PAZO)4-(DAR/Nafion)2...
A multifunctional luminescent immuno-magnetic nanoplatform has achieved fast, efficient, cell-friendly capture and recovery of circulating tumor cells.
Capture of circulating tumor cells (CTCs) with high efficiency and purity holds great value for potential clinical applications. Besides the existing problems contamination from blood plasma proteins, unknown/down-regulated expression targeting markers (e.g., antigen, receptor, etc.) CTCs have questioned reliability general applicability current capture methodologies based on immune/aptamer-affinity. Herein, a cell-engineered strategy is designed to break down such barriers by employing cell...
Encountered with the immunomagnetic hedgehog particles, exosomes were positively selected an exosomal marker (CD63) and negatively by depleting environmental pollutants (protein precipitates, cell debris) TiO 2 nanospikes.
Highly sensitive detection of melanoma-derived exosomal PD-L1 plays a key role in non-invasive diagnosis melanoma. Here, we proposed self-calibrated magnetic aptamer sensor (sCMAS) for melanoma PD-L1, using the dual lanthanide-assisted luminescence as well ratiometric fluorescent probe strategy to overcome limitations caused by systematic or environmental factors, thereby providing more stable and liable output. Generally, sCMAS employs Tb-based nanoparticles (TbNps), which were immobilized...
Fluorescence-based LB (liquid biopsy) offers a rapid means of detecting cancer non-invasively. However, the widespread issue sample loss during purification steps will diminish accuracy detection results. Therefore, in this study, we introduce magnetic lanthanide sensor (MLS) designed for sensitive characteristic protein, epithelial cell adhesion molecule (EpCAM), on tumor exosomes. By leveraging inherent multi-peak emission and time-resolved properties sole-component element, combined with...