A5100430738- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Advanced Photocatalysis Techniques
- 2D Materials and Applications
- Supercapacitor Materials and Fabrication
- Advanced battery technologies research
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Advanced Fluorescence Microscopy Techniques
- Lattice Boltzmann Simulation Studies
- Microfluidic and Bio-sensing Technologies
- Advancements in Battery Materials
- COVID-19 Clinical Research Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Vaccine Coverage and Hesitancy
- Advanced Nanomaterials in Catalysis
- Solar-Powered Water Purification Methods
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
- COVID-19 and healthcare impacts
- Immunotherapy and Immune Responses
- Blood groups and transfusion
- Immune Cell Function and Interaction
- MXene and MAX Phase Materials
- Ubiquitin and proteasome pathways
Sichuan University
2021-2025
Northwestern Polytechnical University
2023-2024
Oregon Health & Science University
2022-2023
University of Southern California
2021-2023
Chengdu University
2021
Changchun Normal University
2021
The light-up magnetic aptamer-sensor Fe<sub>3</sub>O<sub>4</sub>@Au for ultra-sensitive lung cancer exosome detection based on fluorescence resonance energy transfer.
Endolysosomal degradation of small interfering RNA (siRNA) significantly reduces the efficacy interference (RNAi) delivered by nonviral systems. Leveraging Golgi apparatus/endoplasmic reticulum (Golgi/ER) transport can help siRNA bypass endolysosomal pathway, but this approach may also result in insufficient release and an increased risk Golgi/ER-mediated exocytosis. To address these challenges, we developed two distinct strategies using a nanocomplex cell-penetrating poly(disulfide)s...
Abstract The capture of melanoma circulating tumor cells (melanoma CTCs, MelCTCs) is great significance for the early diagnosis and personalized treatment melanoma. rarity heterogeneity MelCTCs have greatly limited development methods, especially those based on immune/aptamer‐affinity. Herein, an extracellular vesicles‐camouflaged strategy designed to functionalize magnetic nanoparticles (Fe 3 O 4 ) generate vesicles @lip/ev) with excellent antifouling active cell targeting properties....
Encountered with the immunomagnetic hedgehog particles, exosomes were positively selected an exosomal marker (CD63) and negatively by depleting environmental pollutants (protein precipitates, cell debris) TiO 2 nanospikes.
Highly sensitive detection of melanoma-derived exosomal PD-L1 plays a key role in non-invasive diagnosis melanoma. Here, we proposed self-calibrated magnetic aptamer sensor (sCMAS) for melanoma PD-L1, using the dual lanthanide-assisted luminescence as well ratiometric fluorescent probe strategy to overcome limitations caused by systematic or environmental factors, thereby providing more stable and liable output. Generally, sCMAS employs Tb-based nanoparticles (TbNps), which were immobilized...
Vanadium (V)-based oxides as cathode materials for aqueous zinc-ion batteries (AZIBs) still encounter challenges such sluggish Zn
Fluorescence nanoscopy has become increasingly powerful for biomedical research, but it historically afforded a small field-of-view (FOV) of around 50 μm × at once and more recently up to ∼200 200 μm. Efforts further increase the FOV in fluorescence have thus far relied on use fabricated waveguide substrates, adding cost sample constraints applications. Here we report PRism-Illumination Microfluidics-Enhanced DNA-PAINT (PRIME-PAINT) multiplexed across millimeter-scale FOVs. Built upon...
Coronavirus disease 2019 (COVID-19) disparities among vulnerable populations are of paramount concern that extend to vaccine administration. With recent uptick in infection rates, dominance the delta variant, and authorization a third booster shot, understanding population-level coverage dynamics underlying sociodemographic factors is critical for achieving equity public health outcomes. This study aimed characterize scope inequity California counties through modeling trends vaccination...
Unconventional 1T′ phase transition metal dichalcogenides (TMDs) show great potential for hydrogen evolution reaction (HER). However, they are susceptible to transitioning into the stable 2H phase, which reduces their catalytic activity and stability. Herein, we present a scalable approach designing thermally 1T′‐TMDs hollow structures (HSs) by etching Cu1.94S templates from pre‐synthesized Cu1.94S@TMDs heterostructures, including 1T′‐MoS2, MoSe2, WS2, WSe2 HSs. Furthermore, taking 1T′‐MoS2...
Abstract Vanadium (V)‐based oxides as cathode materials for aqueous zinc‐ion batteries (AZIBs) still encounter challenges such sluggish Zn 2+ diffusion kinetics and V‐dissolution, thus leading to severe capacity fading limited life span. Here, we designed an ultrafast facile colloidal chemical synthesis strategy based on crystalline 0.25 V 2 O 5 ( c‐ ZVO) successfully prepare a‐ ZVO@MoS core@shell heterostructures, where atomic‐layer MoS uniformly coats the surface of amorphous ZVO. The...
Abstract Fluorescence nanoscopy has become increasingly powerful for biomedical research, but it historically afforded a small field-of-view (FOV) around 50 µm x at once and more recently up to ~200 200 µm. Efforts further increase the FOV in fluorescence have thus far relied on use of fabricated waveguide substrates, adding cost sample constraints applications. Here we report PRism-Illumination Microfluidics-Enhanced DNA-PAINT (PRIME-PAINT) multiplexed across millimeter-scale FOVs. Built...
Enrichment of exosomes with high structural and functional integrity is a critically important step before downstream applications in biological clinical domains. In this work, dynamic interfaces functionalized fructose-responsive immunomagnetic beads (Fr-IMBs) were fabricated by incorporating the composed dopamine 4-carboxyphenylboronic acid beads. These Fr-IMBs successfully applied to capture MCF-7 efficacy 91.0%. After incubation fructose, molecular structure dopamine-boronic complexation...
Correction for ‘A light-up fluorescence resonance energy transfer magnetic aptamer-sensor ultra-sensitive lung cancer exosome detection’ by Nanhang Zhu <italic>et al.</italic>, <italic>J. Mater. Chem. B</italic>, 2021, 9, 2483–2493, DOI: 10.1039/D1TB00046B.
Abstract Recent interest the ability to degrade oncogenic proteins has grown exponentially, and advent of Protein-Targeting Chimeras (PROTACs) allowed many previously undruggable targets be specifically targeted. However, successful development these bioavailable heterobifunctional degraders relies on identification a combination ligase recruiter, linker exit vector that allow formation competent ternary complex target degradation. To this end, conventional single-compound synthesis is...
Background COVID-19 is constantly evolving, and highly populated communities consist of many different characteristics that may contribute to health outcomes. Therefore, we aimed (1) quantify the relationships between county severe non-severe county-level outcomes related COVID-19. We also (2) compare these across time periods where Delta (B.1.617.2) Omicron (B.1.1.529 BA.1.1) variants were dominant in U.S. Methods used multiple regression measure strength healthcare 50 most populous...
Silk-Based Iontronics In article number 2102596, Tiger H. Tao and co-workers report a unique silk-based iontronic composite to simultaneously achieve high conductivity, self-healing, strong stretchability, strain sensitivity transparency, universal adhesiveness across broad working temperature range. Those merits facilitate the implementation of damage-resilient intelligent robotic manipulation.