A5112904038- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Immune Response and Inflammation
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Viral Infections and Immunology Research
- interferon and immune responses
- Chemical Synthesis and Reactions
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Calcium signaling and nucleotide metabolism
- Autophagy in Disease and Therapy
- Kidney Stones and Urolithiasis Treatments
- Cancer Risks and Factors
- Virus-based gene therapy research
- RNA Research and Splicing
- Metabolism, Diabetes, and Cancer
- Muscle and Compartmental Disorders
- Epigenetics and DNA Methylation
- Growth Hormone and Insulin-like Growth Factors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Calpain Protease Function and Regulation
- Parvovirus B19 Infection Studies
- Cancer therapeutics and mechanisms
St. Michael's Hospital
2025
University of Toronto
1992-2025
Guangxi Medical University
2023
Sunnybrook Health Science Centre
1994-1995
Université de Sherbrooke
1994
Ontario Institute for Cancer Research
1992
Chinese Academy of Medical Sciences & Peking Union Medical College
1986
Recent in vitro results suggest that the heterogeneous nuclear ribonucleoparticle (hnRNP) A1 protein modulates alternative splicing by favoring distal 5' splice site (5'SS) selection and exon skipping. We used a mouse erythroleukemia (MEL) cell line (CB3C7) deficient expression of hnRNP to test whether variations AlB levels affected vivo. In contrast A1-expressing MEL lines, CB3C7 cells preferentially selected proximal 13S 12S 5'SS on adenovirus E1A pre-mRNA. Transiently expressing or A1B...
Activation of either Fli-1 or Spi-1 members the ets family transcription factors as a result retroviral insertion and mutational inactivation p53 tumor suppressor gene play essential roles in multistage erythroleukemias induced mice by various strains Friend virus. We have previously identified another common site for provirus integration, designated Fli-2 (Friend leukemia integration 2), some erythroleukemia clones murine virus (F-MuLV) polycythemia-inducing strain complex (FV-P). Here we...
Peritoneal dialysis (PD)-associated peritonitis commonly arises from touch contamination events, however, it is important to be mindful of alternative etiologies and take a detailed history perform root cause analysis for each episode. In fact, the PD effluent can window into intra-abdominal pathologies which may require surgical management. We present an unusual case secondary enteric due foreign body bowel perforation ingestion fish bone.
A single dose of N-methyl-N-nitrosourea given to sexually immature female Buf/N rats produces a high incidence mammary adenocarcinomas. large percentage these tumors contain the Ha-ras oncogene, activated by G----A transition at second nucleotide codon 12. Copenhagen rats, on other hand, are completely resistant tumor induction number carcinogens, including N-methyl-N-nitrosourea. Here we show, using sensitive method involving PCR, that 12 mutations occur in glands both and 30 days after...
Abstract Bufalin, a major cardiotonic compound of the traditional Chinese medicine Chanshu has been used for cancer treatment several years. However, molecular mechanisms Bufalin‐induced autophagy in osteosarcoma (OS) is not fully understood. In present study, it was shown that Bufalin induced crosstalk between apoptosis and autophagy, which resulted OS cell death. Mechanistically, by increased ratio microtubule‐associated protein 1A/1B‐light chain 3 (LC3)‐II/LC3‐I, inducing via...
Nitrosomethylisoamylamine (NMIA), a carcinogenic N-nitroso compound was synthesized from isoamylamine (IAA) in glucose-ammonium nitrate medium after several days' incubation with fungi and subsequent nitrosation sodium nitrate. The nitrosamine not produced by control reactions which lacked either IAA or fungi. yield of NMIA varied the length inoculation fungi, concentrations NaNO2, duration nitrosation, pH species optimum conditions for formation are reported.
Indirect evidence from both epidemiological studies and animal experiments suggests that insulin may promote breast cancer development. In this study, we directly tested for a promoting effect of on mammary carcinogenesis in Sprague-Dawley rats. Fifty day-old female rats received an i.p. injection 37.5 mg/kg methylnitrosourea (MNU). Five days later, the animals were randomized into two groups. One group injections five times/week until time death, while other control similar normal saline....