A5020993466- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Nutrition, Genetics, and Disease
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Stress Responses and Cortisol
- Ion Transport and Channel Regulation
- Estrogen and related hormone effects
- Microbial Community Ecology and Physiology
- Tryptophan and brain disorders
- Cardiovascular Issues in Pregnancy
- Growth Hormone and Insulin-like Growth Factors
- Traditional Chinese Medicine Studies
- Birth, Development, and Health
- Reproductive Health and Contraception
- Sexual Differentiation and Disorders
- Renin-Angiotensin System Studies
- Cardiomyopathy and Myosin Studies
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Gestational Trophoblastic Disease Studies
- Genetic Syndromes and Imprinting
- Proteoglycans and glycosaminoglycans research
- Telemedicine and Telehealth Implementation
- Developmental Biology and Gene Regulation
Chinese Academy of Fishery Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
University of Michigan
2017-2022
Simons Initiative for the Developing Brain
2020
Simons Foundation
2020
Liuyang City Maternal and Child Health Hospital
2018
Anyang Tumor Hospital
2016
Northwest A&F University
2016
Wenzhou Medical University
2016
Ruijin Hospital
2001-2015
Lin28a is a conserved RNA-binding protein that plays an important role in development, pluripotency, stemness maintenance, proliferation and self-renewal. Early studies showed serves as marker of spermatogonial stem cells (SSCs) promotes the capacity mouse SSCs. However, there little information about livestock In this study, we cloned Capra hircus CDS found it evolutionarily conserved. widely expressed different tissues hircus, but at high level testis. specifically located cytoplasm may...
Abstract Context Adrenal tumors in noncancer patients are common. Objective Evaluate performance of 18F-fluorodeoxyglucose positron emission tomography computed (18F-FDG-PET/CT) distinguishing between benign and malignant adrenal tumors. Design Retrospective chart review 2010-2019. Setting Academic institution. Patients One hundred seventeen patients, defined as having no history cancer or with remission for ≥5 years, completed 18F-FDG-PET/CT to evaluate masses, pathologic diagnoses imaging...
Objectives To identify chromosome regions containing hypertension susceptibility genes in Chinese. Subjects and methods A three-stage study was carried out Chinese siblings ascertained through outpatient clinics. In the first stage, 283 affected sib-pairs from 79 nuclear families were subjected to a genome-wide scan with 240 microsatellite marker loci. The second stage focused on 2 additional markers resulting an average distance of 5 cM used independent sample 637 161 families. third...
Abstract The COVID-19 pandemic has prompted the rapid transition of in-person outpatient care to telemedicine, and clinical training remote learning. endocrinology fellows at University Michigan maintain their own continuity-of-care clinics rotate in Ann Arbor Veterans Affairs (VA) Healthcare System. For these clinics, we sought preserve patient staffing with expert attending physicians continue experience a setting. We have adapted online conferencing platform, Zoom, integrate learners into...
Adducin is a membrane skeletal protein that involved in the regulation of ion transport and cellular signal transduction. Essential hypertension has been linked to α-adducin gene locus, association polymorphism found some studies, but results linkage or studies on are controversial among different populations. This study was designed examine between locus essential reveal relationship an (Gly460Trp) Chinese population. For study, one hundred six nuclear families were recruited, including 417...
Background— Genetic studies in mouse and human suggest that kynureninase activity may influence blood pressure renal function. The gene coding ( KYNU ) is also located on chromosome band 2q14-q23, where a linkage peak for essential hypertension was previously detected the Chinese Han population. Methods Results— After having found no association with common polymorphisms, this study aimed to assess role of 1 rare variant , Arg188Gln, relation hypertension. Thirty-three 1124 patients were...
To screen the gene mutation in beta and gamma subunits of epithelial sodium channel (ENaC) a Chinese family, some whose members are clinically diagnosed as suffering from Liddle syndrome.Twelve family were recruited to study. Among them, two brothers had been syndrome. Peripheral blood samples collected all total genomic DNA was prepared for genetic analysis. Polymerase chain reaction (PCR) used amplifying last exon (codon 513-673) 503-632) ENaC gene. PCR products purified subjected direct...
Abstract Background Differentiated thyroid cancer uncommonly presents with distant metastases. Adrenal metastasis from differentiated presenting as the initial finding is even less common. Case Presentation A 71-year-old male was incidentally found on chest CT to have bilateral nodules, which were confirmed ultrasound. Fine needle aspiration of dominant right 3.3 cm nodule contained histologic features most consistent Bethesda classification III, and repeat fine revealed pathology II....
To the authors' knowledge, limited data are available regarding association between Electrocardiogram (ECG) signs of right ventricular hypertrophy (RVH) and pulmonary hypertension (PH) in patients with dilated cardiomyopathy (DCM). We aimed to assess accuracy recommended ECG criteria RVH for predicting PH DCM. According definition (mPAP ≥ 25 mm Hg), 35 DCM were divided into 2 groups: (n = 22) without 13). Right heart catheterization was performed all patients. Seventeen parameters by...
Objective We investigated, in a sample of Chinese families, the associations body mass index (BMI), blood pressure (BP), serum lipids, fasting plasma glucose, creatinine and uric acid with insertion/deletion (I/D) polymorphism angiotensin-converting enzyme (ACE) gene. Methods genotyped 902 subjects from 186 nuclear families recruited Shanghai, China, via specialized hypertension clinic. performed family-based association analyses for continuous dichotomous phenotypic measurements using...
Abstract Background Nelson’s syndrome is a well-described complication following bilateral adrenalectomy for management of Cushing’s disease. There no consensus on optimal syndrome, characterized by the triad pituitary corticotroph adenoma growth, elevated serum adrenocorticotropic hormone, and skin hyperpigmentation. Medical therapy with variety drug classes have been studied. One potentially promising already approved disease pasireotide, somatostatin analog affinity multiple receptors,...
Abstract Context Adrenal-derived 11-oxygenated androgens (11oAs) are known important contributors to human physiology and disease but have not been studied in pregnancy. Objective We characterize 11oAs normal pregnancy neonatal period assess the ratios between compare with of other steroids that undergo placental metabolism. Design Prospective cohort study, 2010-2018. Setting Academic institution. Patients Pairs pregnant women newborns (n = 120) were studied. Inclusion criteria maternal age...