Background/Aims: Microglia, which represent the immune cells of central nervous system (CNS), have long been a subject study in CNS disease research. Substantial evidence indicates that microglial activation functions as strong neuro-inflammatory response neuropathic pain, promoting release pro-inflammatory cytokines, such tumor necrosis factor (TNF)-α. In addition, activated microglia brain-derived neurotrophic (BDNF), acts powerful cytokine. this study, we performed series vitro...

Existing treatments for chronic pain often prove ineffective and carry adverse side effects, highlighting the need better analgesics, including non-pharmacological treatments. We demonstrate that transcutaneous electrical nerve stimulation (TENS), when repeatedly applied during early phase of injury, produces sustained analgesic effects by activating dorsal column nucleus-thalamic-cortical pathway, which transmits vibration, discriminative touch, proprioception. Mechanistically, TENS...

Background: Post-amputation pain (PAP) is highly prevalent after limb amputation, and stump neuromas play a key role in the generation of pain. Presently, PAP refractory to medical management frequently treated with minimally invasive procedures guided by ultrasound, such as alcohol neurolysis radiofrequency ablation (RFA). Objective: To record immediate long-term efficacy RFA. We first used then, when necessary, we performed RFA on patients. Study design: Prospective case series. Setting:...

Cervical transforaminal epidural steroid injection (CTFESI) is used to provide pain relief and restore function in patients with cervical radiculopathy. Traditionally, it performed under the guidance of fluoroscopy or computed tomography. Here, we introduce a novel technique - ultrasound-guided CTFESI which operators can easily distinguish close soft tissue (nerve, vessels) around foramina avoid intravascular during procedure.To present immediate long-term effectiveness radiculopathy an...

<i>Background:</i> Neuropathic pain is one of the most challenging clinical problems due to a lack understanding mechanisms. Recent studies have suggested that activated microglia in spinal cord may play vital role nerve injury-induced neuropathic pain, but exact mechanisms not been fully determined. <i>Methods:</i> First, we investigated changes dorsal horn GABA(B) receptor 1 (R1) expression ligation rats. Second, explored whether contributed such neuron by...

The mechanisms of chronic neuropathic pain are not clear. Serum microRNAs (miRNAs) might show a special feature for nervous lesions. However, little is known about the changes in circulating miRNAs pain. Therefore, expression profile were investigated. was collected from rats before and after spinal nerve ligation (SNL) surgery, microarray analysis performed to determine miRNA profile. inflammatory cytokines serum same individuals, including interleukin-6 (IL-6), tumor necrosis factor-α...

Paclitaxel (Taxol) is a powerful chemotherapy drug used in breast cancers, but it often causes neuropathic pain, leading to the early cessation of therapy and poor treatment outcomes. Approaches for management paclitaxel-induced pain are urgently needed. The involvement spinal astrocytes pathogenesis neuropathy has been reported, little known about role fluorocitrate (FC), selective inhibitor astrocyte activation, during related paclitaxel treatment. In this study, we investigated effects FC...

Post-amputation pain causes great suffering to amputees, but still no effective drugs are available due its elusive mechanisms. Our previous clinical studies found that surgical removal or radiofrequency treatment of the neuroma at axotomized nerve stump effectively relieves phantom afflicting patients after amputation. This indicated an essential role residual in formation chronic post-amputation (CPAP). However, molecular mechanism by which is involved and regulates CPAP a mystery. In this...

Abstract Brain metastasis affects approximately 20%–30% of patients with triple-negative breast cancers (TNBCs). Even small metastatic lesions in the brain can trigger severe neurological impairments and result extremely short survival time. Recently, active astrocytes were reported to be associated metastases. However, how activated regulate behaviors disseminated cancer cells remains unknown. In this study, human primary stimulated IL-1β form study cross-talk between stromal (astrocytes)...

Neuroma formation after peripheral nerve transection leads to severe neuropathic pain in amputees. Previous studies suggested that physical exercise could bring beneficial effect on alleviating pain. However, the of neuroma still remained unclear. In addition, long-term can affect expression neurotrophins (NT), such as growth factor (NGF) and brain-derived neurotrophic (BDNF), which play key roles nociceptor sensitization sprouting injury. Here, we investigated whether swimming relieve by...

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy because it often diagnosed at late-stage. Signal transducer and activator of transcription 5 (STAT5) factor implicated in the progression various cancer types. However, its role KRAS-driven pancreatic tumourigenesis remains unclear.

Objective: Postamputation pain (PAP) is a serious problem, and thus far, there no perfect treatment strategy.Clinically, minimally invasive treatments for peripheral neuromas are simple feasible.This study aimed to investigate the immediate long-term effects of ultrasonography-guided radiofrequency ablation (RFA) on PAP.Methods: Eighteen PAP subjects with painful were treated RFA.Results: A total 18 included in final analyses.Fourteen 17 residual limb (RLP) (82.4%) had successful outcomes.A...

Abstract Objective To observe whether ultrasound-guided stellate ganglion block (SGB) can effectively relieve migraine pain and improve the quality of patients’ life. Methods 81 patients with migraines were enrolled in this study. The received SGB 6 ml 0.15% ropivacaine once every week for four times. Migraine was assessed Disability Assessment Scale (MIDAS) at baseline three-months follow-up (Tm). numerical rating scale (NRS) score baseline, one day after treatment (Td) Tm, frequency...

Objective As for ultrasound (US) guided stellate ganglion (SG) block, unsatisfactory curative outcomes and complications still remain. This problem could be greatly improved by identifying monitoring SG. To the best of our knowledge, there are few reports to directly visualize SG in literature. study explored feasibility detection summarized findings through US. Methods Fifty healthy adults with 100 SGs were enrolled. The size, shape, echogenicity, margin, inferior pole SG, relationship...

Nerve damage often leads to nervous system dysfunction and neuropathic pain. The serine-threonine kinases receptor-interacting protein 1 (RIP1) 3 (RIP3) are associated with inflammation cell necrosis. This study aimed explore the role of RIP1 RIP3 in sciatic nerve chronic constriction injury (CCI) mice. On a total thirty mice, CCI was performed. paw withdrawal threshold measured using Von Frey filaments. mRNA expression levels inflammatory factors dorsal root ganglion (DRG), spinal cord (SC)...

Thoracic nerve root (TNR) block is performed primarily under computed tomography or X-ray fluoroscopy but associated with radiation exposure. Ultrasound requires no and distinguishes vessels, nerves, pleura, other tissues. Few reports of ultrasound-guided TNR (US-TNR) have been described, the puncture end point has not clearly defined. Herein, we evaluated feasibility US-TNR using midpoint inferior articular process (IAP) parietal pleura (PP) as point.A prospective series 10 patients Herpes...

The aim of the present study was to investigate effectiveness and safety a novel lateral in-plane approach for ultrasound-guided transforaminal cervical nerve root block (US-guided TF-CNRB) in treatment radiculopathic pain.The design consisted an institutional, retrospective case series.The conducted at university hospital.Thirty-two patients with radiculopathy who were resistant conservative therapies regular US-guided CNRB included as participants.The treated TF-CNRB. During treatments,...

The stellate ganglion block (SGB) can lead to vasodilation of the head and neck. However, controversy remains concerning changes in extracerebral blood flow. objective this study is assess effects SGB on flow A randomized controlled crossover trial with 38 participants will be conducted. Participants who have primary headaches assigned either group or B. Patients receive 6 ml 1% lidocaine, after a one-week washout period, they undergo second normal saline. In contrast, patients B opposite...

Complex regional pain syndrome type 1 (CRPS-1) is prevalent after trauma, with intractable being the most prominent clinical symptom. The impact of sympathetic block on CRPS unclear. goal this study was to explore characteristics that predict successful symptom relief lumbar (LSB) in patients lower extremity CRPS-1. designed as a prospective cohort study. Ninety-eight diagnosed CRPS-1 between March 2021 and 2022 were enrolled participants. All received two LSB treatments within month....