A5100354372- Natural product bioactivities and synthesis
- Synthesis and biological activity
- Phytochemistry and Biological Activities
- Spectroscopy and Chemometric Analyses
- Cancer-related gene regulation
- Traditional Chinese Medicine Analysis
- Pharmacological Receptor Mechanisms and Effects
- Electrospun Nanofibers in Biomedical Applications
- Spinal Cord Injury Research
- Heavy Metals in Plants
- Bee Products Chemical Analysis
- Breastfeeding Practices and Influences
- Osteoarthritis Treatment and Mechanisms
- Synthesis and Reactions of Organic Compounds
- Bacterial Identification and Susceptibility Testing
- Microbial Metabolism and Applications
- Infant Nutrition and Health
- Surface Modification and Superhydrophobicity
- Advanced Materials and Mechanics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advancements in Transdermal Drug Delivery
- Wnt/β-catenin signaling in development and cancer
- Ionic liquids properties and applications
- Nuts composition and effects
Zhejiang Sci-Tech University
2024
Guangxi University of Chinese Medicine
2020-2023
Guangzhou Medical University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2023
Guang’anmen Hospital
2023
Zhejiang University of Technology
2023
Sichuan University
2023
Guangxi University
2020-2023
Henan University Huaihe Hospital and Huaihe Clinical Institute
2019
Institute of Food Science and Technology
2019
Osteoarthritis (OA) is one of the most characterized joint diseases associated with chondrocyte apoptosis. Juglanin has been reported to have anti-inflammation activity. This study aimed evaluate protective anti-inflammatory effects juglanin in human OA chondrocytes. Human chondrocytes were pretreated (10, 20 and 40 μM) for 2 h subsequently stimulated IL-1β 24 h. Nitric oxide (NO) production was determined using Griess method prostaglandin E2 (PGE2), matrix metalloproteinase-3, -9 -13...
Great progress has been achieved in the study of aerobic glycolysis or so-called Warburg effect a variety cancers; however, regulation Nasopharyngeal carcinoma (NPC) not completely defined. Gene expression pattern NPC cells were used to test associations between Chibby and β-catenin expression. siRNAs over-expression vector transfected into down-regulate up-regulate Loss- gain-of function assays performed investigate role cells. Western blot, cell proliferation, Glucose uptake, Lactate...
METTL3, an RNA methyltransferase enzyme, exerts therapeutic effects on various cardiovascular diseases.Myocardial ischemia-reperfusion injury (MIRI) and subsequently cardiac fibrosis is linked to acute cardiomyocyte death or dysfunction induced by mitochondrial damage, particularly fission.Our research aims elucidate the potential mechanisms underlying actions of METTL3 in MIRI, with focus fission.When compared Mettl3 flox mice subjected knockout (Mettl3 Cko ) have reduced infarct size,...
Abstract BACKGROUND To develop an environment‐friendly approach for the synthesis of (S)‐1‐(2,6‐dichloro‐3‐fluorophenyl) ethyl alcohol, intermediate anti‐cancer drug Crizotinib, aldehyde ketone reductase and alcohol dehydrogenase were overexpressed in Escherichia coli Rosetta (DE3) purified via chromatography. Subsequently, they co‐crystalized with CaHPO 4 at 4°C to form dual‐enzyme@CaHPO hybrid nanoflowers (hNFs) which was then used catalyze along evaluation its thermal stability recycling...
NF-κB and MAPK are classic inflammation signaling pathways which regulate signal transmission induce the expression of many inflammatory factors. Based on potent anti-inflammatory activity benzofuran its derivatives, several new heterocyclic/benzofuran hybrids were first designed synthesized by molecular hybridization. Their structure was confirmed 1H NMR, 13C HRMS or X-single crystal diffraction. The these compounds screened compounds; compound 5d exhibited an excellent inhibitory effect...
Specific chromatin characteristics, especially the modification status of core histone proteins, are associated with active and inactive genes. There is growing evidence that genes respond to environmental or developmental signals may possess distinct marks. Using a T cell model both genome-wide gene-focused approaches, we examined characteristics activation.To facilitate comparison similar basal expression levels, used expression-profiling data bin according their levels. We found inducible...
Background: Nuezhenide (NZD), an iridoid glycoside isolated from Ilex pubescens Hook. & Arn. var. kwangsiensis Hand.-Mazz., used as a traditional Chinese medicine for clearing away heat and toxic materials, displays variety of biological activities such anti-tumor, antioxidant, other life-protecting activities. However, few studies involving anti-inflammatory activity the mechanism NZD have also been reported. In present study, antioxidative effects are illustrated. Objective: This study...
Hyperspectral imaging technology was employed to detect slight bruises on Korla pears. The spectral data of 60 bruised samples and normal were collected by a hyperspectral system. To select the characteristic wavelengths for detection, several chemometrics methods used raw spectra. Firstly, principal component analysis (PCA) conducted spectra ranging from 420 1000 nm all samples. Considering that reliability first two PCs more than 90%, five (472, 544, 655, 688 967 nm) selected loading plot...
Forty-two putative Cryptococcus laurentii isolates identified by the Vitek 2 system were collected in China. The gold standard, internal transcribed spacer (ITS) sequencing, confirmed that only two genuine C. laurentii. Bruker Biotyper matrix-assisted laser desorption ionization-time of flight mass spectrometry was able to identify with an expanded custom database.
Acute high-altitude diseases, including acute mountain sickness (AMS), cerebral edema (HACE), and pulmonary (HAPE), have been recognized as potentially lethal diseases for altitude climbers. Various preconditioning stimuli, hyperbaric oxygen (HBO), proposed to prevent diseases. Herein, we reviewed whether how HBO could affect summarized the results of current trials. Evidence suggests that may be a safe effective preventive method The mechanisms in preventing involve: 1) protection...
Ilicis Rotundae Cortex (IRC) consists of the bark Ilex rotunda Thunb, and its chemical constituents mainly include flavonoid glycosides, phenols, triterpenoid saponins. In this study, a preliminary analysis was performed to identify obtain components from IRC better control quality medicinal materials provide basis for study efficacy active components. Simple efficient sample pretreatment ultrasonic-assisted extraction methods were used analyze mass spectrum fragments fracture modes in anion...
Abstract BackgroundTanshinone I (TI) is a primary component of Salvia miltiorrhiza Bunge (Danshen), which confers favorable role in variety pharmacological activities including cardiovascular protection. However, the exact mechanism protection activity TI remains to be illustrated. In this study, protective effect and its were investigated.MethodsIn tert-butyl hydroperoxide (t-BHP)-stimulated H9c2 cells model was employed investigate vitro . The cell viability determined by 3-(4,...
Objective To evaluate the performance of domestic matrix-assisted laser desorption/ionization time-of-flight mass spectrometry system Clin-TOF-Ⅱ MS with BioExplorer V2.3 database (Clin-TOF system) on gram-negative bacteria identification. Methods This was a methodological comparison study. A total 1 025 strains 32 genus, 56 species or complex were included in this study from 1999 to 2000 and 2014 2016 Peking Union Medical College Hospital.The Bruker Biotyper (Bruker system), Autoflex...
Амурский медицинский журнал №3 (19) 2017Immunosuppressive therapy is used in the pathogenetic treatment of rheumatoid arthritis.Methotrexate for arthritis considered current gold standard first line treatment.In recent years, combination methotrexate and genetic engineering biological drugs with high efficiency.