A5101574651- RNA modifications and cancer
- RNA Research and Splicing
- Urological Disorders and Treatments
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Pelvic and Acetabular Injuries
- Bladder and Urothelial Cancer Treatments
- Nanoplatforms for cancer theranostics
- Abdominal Trauma and Injuries
- MicroRNA in disease regulation
- Sulfur Compounds in Biology
- T-cell and B-cell Immunology
- Agriculture and Biological Studies
- Genetic diversity and population structure
- Animal Diversity and Health Studies
- Identification and Quantification in Food
- Virus-based gene therapy research
- Hydrogen's biological and therapeutic effects
- Transplantation: Methods and Outcomes
- Urinary Bladder and Prostate Research
- Genetic and phenotypic traits in livestock
- Extracellular vesicles in disease
- Ureteral procedures and complications
- Tissue Engineering and Regenerative Medicine
ShenZhen People’s Hospital
2023
Longgang Central Hospital
2016-2021
Inner Mongolia Agricultural University
2021
Guangdong Medical College
2020-2021
Oregon State University
2015-2016
Abstract Photodynamic therapy (PDT) by insertion of an optical fiber into the bladder cavity has been applied in clinic for noninvasive treatment tumors. To avoid systemic phototoxicity, intravesical instillation a photosensitizer may be ideal approach PDT cancer, comparison to conventional intravenous injection. However, instillation‐based cancer remains less effective due poor urothelial uptake photosensitizer, as well tumor hypoxia‐associated resistance. Herein, it is uncovered that...
Hydrogen gas can mitigate oxidative stress in many diseases and is regarded to be safe free of side effects. Inspired by a metalloenzyme variety microorganisms, here, we propose photoactivated H2 nanogenerator that comprises fluorinated chitosan (FCS), chemotherapeutic drug (gemcitabine, GEM), catalyst production ([FeFe]TPP) form self-assembled [FeFe]TPP/GEM/FCS nanoparticles (NPs). The NPs exhibit excellent transmucosal tumor cell penetration capacities after intravesical instillation into...
Abstract Prostate cancer is the second most frequent malignancy in men worldwide, and its incidence increasing. Therefore, it urgently required to clarify underlying mechanisms of prostate cancer. Although long non‐coding RNA LINC00115 was identified as an oncogene several cancers, expression function have not been explored. Our results showed that significantly up‐regulated tissues, which associated with a poor prognosis for patients. Functional studies knockdown inhibited cell...
Abstract Aryl hydrocarbon receptor (AhR) activation by high-affinity ligands mediates immunosuppression in association with increased regulatory T cells (Tregs), making this transcription factor an attractive therapeutic target for autoimmune diseases. We recently discovered 10-chloro-7H-benzimidazo[2,1-a]benzo[de]iso-quinolin-7-one (10-Cl-BBQ), a nanomolar affinity AhR ligand immunosuppressive activity and favorable pharmacologic properties. In study, we tested the consequences of NOD...
Computed tomography (CT) is most commonly used as a noninvasive approach in diagnosis of internal organ injures. Use multi-slice spiral CT becomes more popular trauma because its ability to generate 3D volumetric information. This study evaluated the diagnostic value computed (MSCT) with enhanced scanning renal trauma. In total, 126 patients kidney injury underwent MSCT from single hospital southern China between January 2012 and February 2016. According grading standards American...
Clear cell renal carcinoma (ccRCC) is the most aggressive urologic tumor, and its incidence diagonosis have been continuously increasing. Identifying novel molecular biomarker for inhibiting progression of ccRCC will facilitate developing new treatment strategies. Although methyltransferase-like 7B (METTL7B) was identified as a Golgi-associated methyltransferase, function mechanism METTL7B in development has not explored. expression were significantly upregulated tissues (n = 60), which...
Abstract Dysregulated circWHSC1 has been shown to play potential roles in diverse cancer types, including ovarian cancer, endometrial and hepatocellular carcinoma (HCC). The objective of this study was investigate its expression, underlying role regulatory mechanism non‐small‐cell lung (NSCLC). expression determined by real‐time PCR. After knockdown NSCLC cells, the proliferation, migration, invasion were detected using CCK‐8, colony formation, Transwell assays, effects on tumorigenesis vivo...
Abstract Background Porcine vascular endothelial cells are a major participant in xenograft rejection. The Toll‐like receptor 2 (TLR2) pathway plays an important role both innate and adaptive immunity. specific of TLR2 the response to has not been reported. Whether pig is involved acute rejection needs be investigated, mechanism explored. Methods We used modified antibody‐dependent complement‐mediated cytotoxicity (ADCC) assay conduct vitro experiments. In porcine iliac artery (PIECs), siRNA...
Purpose: Male urethral injury is a common urologic emergency in developing countries. Whether early or late treatment of injuries often multifactorial and controversial. The goal this study to determine whether realignment can reduce postsurgical complications evaluate the clinical feasibility endoscopic urethroplasty using single rigid ureteroscopy bulbar severe injury. Patients Methods: Between September 2013 March 2019, 15 male adult patients (mean age 35 years; from 21 62 years) with...
It has been reported that circular RNA hsa_circ_0074032 (circ_0074032) a higher level in prostate cancer (PCa) tissues. However, the role and regulatory mechanism of circ_0074032 PCa are still unknown. Circ_0074032 was overexpressed PCa, high associated with worse PCa-related prognosis. Functionally, silencing decreased xenograft tumour growth vivo induced cell apoptosis, curbed proliferation, migration invasion cells vitro. Furthermore, identified as miR-198 decoy, inhibition abolished...
Objective: To explore the correlates of sexual dysfunction and lower urinary tract symptoms (LUTS) in male patients with bladder stones to determine effect stone extraction on recovery function. Materials Methods: A total 87 primary were studied from January 2015 May 2016. All underwent pneumatic lithotripsy for stones. Sexual was assessed based function assessment scales. The relationship or LUTS using a two-sample t -test. Postoperative improvement by repeated measures Analysis Variance...
<p class="Abstract">Prostate cancer is major cause of related deaths worldwide in men. There are new treatment methods and drugs being developed with promising results two the prostate cell lines (PPC-1 TSU-Pr1). These cells were treated 20 uM axitinib combined dasatinib for 6-72 hours. The viability assessed by cytotoxicity assay. Various regulatory genes such as c-KIT, cycle apoptosis angiogenic factors also studied. enzyme activity efector caspase-3 was colorimetrically determined....
Abstract Activation of AhR in CD4+ T cells leads to suppression Th1-, Th2- and Th17-mediated immune responses. In allograft models, the first 3 days response represent a critical window for activation during which significant changes donor occur. However, little is known about mechanisms that underlie this early cell sensitivity whether limiting signaling sufficient suppress response. We used rapidly metabolized ligand, 10-Cl-BBQ, show alone indeed GVHD. Early was also increase frequency...
Background: Lymph node (LN) metastasis is the leading cause of bladder cancer-related mortality. Splicing factors facilitate cancer progression by modulating oncogenic variants, but it unclear whether and how splicing regulate LN metastasis.
Objective To evaluate the diagnostic value and clinical significance of multi-slice spiral CT (MSCT) enhanced scanning in blunt renal trauma. Methods The data 116 patients with trauma treated our hospital from January 2012 to December 2017 were analyzed. All these cases underwent abdomen MSCT scans 92 scans, 41 performed excretory phase scan. The manifestations analyzed, compared B ultrasound results, rates diagnosis kidney compared. Results According criterion Association for...