A5087378025- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Disaster Response and Management
- T-cell and B-cell Immunology
- Environmental Justice and Health Disparities
- Effects and risks of endocrine disrupting chemicals
- Immune Cell Function and Interaction
- Climate Change and Health Impacts
- Air Quality Monitoring and Forecasting
- Immune Response and Inflammation
- Chemical Safety and Risk Management
- Environmental Education and Sustainability
- Noise Effects and Management
- Atmospheric chemistry and aerosols
- Disaster Management and Resilience
- Estrogen and related hormone effects
- Atmospheric and Environmental Gas Dynamics
- Health Literacy and Information Accessibility
- Risk Perception and Management
- Fire dynamics and safety research
- Data-Driven Disease Surveillance
- Health, Environment, Cognitive Aging
- Assistive Technology in Communication and Mobility
- Fire effects on ecosystems
- Tryptophan and brain disorders
Oregon State University
2016-2025
Health and Human Development (2HD) Research Network
2019
Corvallis Environmental Center
2019
Center for Environmental Health
2015
Society of Environmental Toxicology and Chemistry
2013
Air quality impacts from wildfires are poorly understood, particularly indoors. As frequencies increase, it is important to optimize methodologies understand and reduce chemical exposures wildfires. Public health recommendations use air estimates outdoor stationary monitors, discounting indoor conditions, do not consider chemicals in the vapor phase, known elicit adverse effects. We investigated vapor-phase polycyclic aromatic hydrocarbons (PAHs) before, during, after using a...
To assess differences and trends in personal chemical exposure, volunteers from 14 communities Africa (Senegal, South Africa), North America (United States (U.S.)) (Peru) wore 262 silicone wristbands. We analysed wristband extracts for 1530 unique chemicals, resulting 400 860 data points. The number of detections ranged 4 to 43 per wristband, with 191 different chemicals detected, 1339 were not detected any wristband. No two wristbands had identical detections. 13 potential endocrine...
Natural gas extraction (NGE) has expanded rapidly in the United States recent years. Despite concerns, there is little information about effects of NGE on air quality or personal exposures people living working nearby. Recent research suggests emits polycyclic aromatic hydrocarbons (PAHs) into air. This study used low-density polyethylene passive samplers to measure concentrations PAHs near active (n = 3) and proposed 2) sites. At each site, two concentric rings were placed around well pad...
Abstract Background In August 2017, Hurricane Harvey caused unprecedented flooding across the greater Houston area. Given potential for widespread flood-related exposures, including mold and sewage, emotional mental toll by flooding, we sought to evaluate short- long-term impact of exposures on health Houstonians. Our objectives were assess association with allergic symptoms stress among Houston-area residents at two time points: within approximately 30 days (T1) 12 months (T2) after...
Rapid health outcome data acquisition using existing questionnaires can greatly facilitate time-sensitive research during or after a wildfire event. We aimed to develop readily available library of for self-reported outcomes serve as centralized platform researchers seeking quickly design instruments tailored their aims. In this paper, we describe the methodology used identify relevant and compile them into structured library. first followed Preferred Reporting Items Systematic reviews...
Americans spend approximately 90% of their time indoors, with more than 66% that spent in residential buildings. Factors pertaining to household behavior or environmental factors may influence types semi-volatile organic compounds (SVOC) found indoors. Paired indoor and outdoor passive samplers were deployed at twenty-four locations across the United States. Samples analyzed for >1500 SVOCs identify common patterns exposure profiles investigate influences factors. Unique differences...
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays multiple roles in regulation of immune and inflammatory responses. ability certain AhR ligands to induce regulatory T cells (Tregs) has generated interest developing for therapeutic treatment immune-mediated diseases. To this end, we designed screen novel Treg-inducing compounds based on our understanding the mechanisms Treg induction by well-characterized immunosuppressive ligand,...
Abstract Aryl hydrocarbon receptor (AhR) activation by high-affinity ligands mediates immunosuppression in association with increased regulatory T cells (Tregs), making this transcription factor an attractive therapeutic target for autoimmune diseases. We recently discovered 10-chloro-7H-benzimidazo[2,1-a]benzo[de]iso-quinolin-7-one (10-Cl-BBQ), a nanomolar affinity AhR ligand immunosuppressive activity and favorable pharmacologic properties. In study, we tested the consequences of NOD...
The human behavioral modification recommendations during wildfire events are based on particulate matter and may be confounded by the potential risks of gas-phase pollutants such as polycyclic aromatic hydrocarbons (PAHs). Moreover, majority adults spend over 90% their time indoors where there is an increased concern indoor air quality events. We address these timely concerns evaluating paired outdoor PAH concentrations in residential locations relationship with satellite model-based...
In 2015, the Swinomish Indian Tribal Community (SITC) was impacted by an air toxic release from one of two nearby oil refineries. This experience motivated SITC members to learn more about their exposure toxics. On invitation SITC, this community-based study measured personal polycyclic aromatic hydrocarbons (PAHs) and conducted interviews with volunteers evaluate perceptions data participating. Non-smoking were recruited in March 2016 (N = 10) January 2017 22) seven participating both...
Hurricane Harvey was associated with flood-related damage to chemical plants and oil refineries, the flooding of hazardous waste sites, including 13 Superfund sites. As clean-up efforts began, concerns were raised regarding human health impact possible increased exposure resulting from hurricane subsequent flooding. Personal sampling devices in form silicone wristbands deployed a longitudinal panel individuals (n = 99) within 45 days again one year later Houston metropolitan area. Using gas...
During events like the COVID-19 pandemic or a disaster, researchers may need to switch from collecting biological samples personal exposure samplers that are easy and safe transport wear, such as silicone wristbands. Previous studies have demonstrated significant correlations between urine biomarker concentrations chemical levels in We build upon those use novel combination of descriptive statistics supervised statistical learning evaluate relationship polycyclic aromatic hydrocarbon (PAH)...
Abstract Activation of the aryl hydrocarbon receptor (AhR) by immunosuppressive ligands promotes development regulatory T (Treg) cells. Although AhR‐induced Foxp3 + Treg cells have been well studied, much less is known about and fate Type 1 (AhR‐Tr1) In current study, we identified unique transcriptional functional changes in murine CD4 that accompany differentiation AhR‐Tr1 during T‐cell‐dependent phase an allospecific cytotoxic lymphocyte (allo‐CTL) response. AhR activation increased...
A challenge in environmental health research is collecting robust data sets to facilitate comparisons between personal chemical exposures, the environment and outcomes. To address this challenge, Exposure, Location lung Function (ELF) tool was designed collaboration with communities that share concerns. These concerns centered on respiratory ambient air quality. The ELF collects exposure polycyclic aromatic hydrocarbons (PAHs), given their association diminished function. Here, we describe...
Activation of the aryl hydrocarbon receptor (AhR) by its prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mediates potent suppression T-cell dependent immune responses. The suppressive effects TCDD occur early during CD4(+) differentiation in absence on proliferation and have recently been associated with induction AhR-dependent regulatory T-cells (Treg). Since AhR functions as a ligand-activated transcription factor, changes gene expression induced stages are likely to reflect...
Environmental health literacy (EHL) is defined as the understanding of how environment can impact human health, yet there are few tools to quantify EHL. We adapted Short Assessment Health Literacy (SAHL) create (SA-EHL). Using Amazon mTurk platform, users (n = 864) completed 18-item SAHL and 17-item SA-EHL. The SA-EHL was originally tested with 30 items; 13 items were removed because they outside acceptable difficulty parameters (DIFF: −0.4–4.0) or limited variance (>90% correct...
Disaster research faces significant infrastructure challenges: regional and federal coordination, access to resources, community collaboration. Disasters can lead chemical exposures that potentially impact human health cause concern in affected communities. Community-engaged research, which incorporates local knowledge voices, is well-suited for work with communities experience impacts of environmental following disasters. We present three examples community-engaged disaster (CEnDR) oil...
In west Eugene (Oregon), community research indicates residents are disproportionately exposed to industrial air pollution and exhibit increased asthma incidence. Carroll County (Ohio), recent increases in unconventional natural gas drilling sparked quality concerns. These concerns led the development of a prototype mobile device measure personal chemical exposure, location, respiratory function. Working directly with environmental justice (EJ) communities, was developed 1) meet needs 2)...
In the U.S., privately owned wells are not subject to any regulatory testing requirements. Well owners must have sufficient environmental health literacy (EHL) understand and interpret information that contain complex terms labels manage their water quality. The objective of this paper is assess performance validity a new EHL screening tool. Water Environmental Literacy Level Scale (WELLS) based on Newest Vital Sign (NVS) contains six questions comprehension, calculations application...
Report-back of research results (RBRR) is becoming standard practice for environmental health studies. RBRR thought to increase literacy (EHL), although standardized measurements are limited. For this study, we developed a report back document on exposure air pollutants, Polycyclic Aromatic Hydrocarbons, during pregnancy through community engaged and evaluated whether the increased EHL. We used focus groups surveys gather feedback from an initial group study participants (Group 1, n = 22)...
Activation of the aryl hydrocarbon receptor (AhR) by its prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), induces potent suppression an acute graft-versus-host (GVH) response and prevents GVH disease (GVHD). Suppression is associated with development a regulatory population donor CD4+ CD25+T-cells that express high levels cytotoxic T-lymphocyte antigen 4 (CTLA-4). However, direct link between these AhR-induced Tregs (AhR-Tregs) GVHD remains to be shown. CTLA-4 negative...