A5100708946- Nutrition and Health in Aging
- Frailty in Older Adults
- Enhanced Recovery After Surgery
- IL-33, ST2, and ILC Pathways
- Gastric Cancer Management and Outcomes
- Clinical Nutrition and Gastroenterology
- Muscle Physiology and Disorders
- Esophageal and GI Pathology
- Berberine and alkaloids research
- Genetics, Aging, and Longevity in Model Organisms
- Adipose Tissue and Metabolism
- Anesthesia and Neurotoxicity Research
- Genomics, phytochemicals, and oxidative stress
- Abdominal Surgery and Complications
- Diet and metabolism studies
- Cardiac, Anesthesia and Surgical Outcomes
- Fatty Acid Research and Health
- Body Composition Measurement Techniques
- Gut microbiota and health
- Colorectal Cancer Surgical Treatments
- Ginseng Biological Effects and Applications
- Stoma care and complications
- Telomeres, Telomerase, and Senescence
- Pancreatitis Pathology and Treatment
- Cytokine Signaling Pathways and Interactions
Tongji University
2015-2025
Shanghai Institute of Pollution Control and Ecological Security
2025
First Affiliated Hospital of Wenzhou Medical University
2010-2024
Shanghai Tenth People's Hospital
2014-2024
Wenzhou Medical University
2010-2024
Jintan People's Hospital
2023
Fujian Academy of Medical Sciences
2020-2023
Soochow University
2023
Fujian Medical University
2023
Jiangsu University
2023
Senescent cells contribute to age-related pathology and loss of function, their selective removal improves physiological function extends longevity. Rapamycin, an inhibitor mTOR, inhibits cell senescence in vitro increases longevity several species. Nrf2 levels have been shown decrease with aging silencing gene induces premature senescence. Therefore, we explored whether is involved the mechanism by which rapamycin delays In wild-type (WT) mouse fibroblasts, increased Nrf2, this correlates...
Ginsenoside Rb1 (GRb1), one of the principle active ingredients Panax ginseng, exerts multiple pharmacological activities to fight fatigue. In present study, we investigate anti-fatigue effect GRb1 on postoperative fatigue syndrome (POFS) in a rat model induced by major small intestinal resection. (10 mg/kg) was administrated intraperitoneally once daily for 1, 3, 7, and 10 d from operation day. Anti-fatigue assessed grasping test biochemical parameters blood or skeletal muscle were...
Background and Aims Berberine its derivatives display potent analgesic, anti-inflammatory anticancer activity. Here we aimed at characterizing the mechanism of action berberine in gastrointestinal (GI) tract cortical neurons using animal models vitro tests. Methods The effect was characterized murine mimicking diarrhea-predominant irritable bowel syndrome (IBS-D) symptoms. Then opioidantagonists were used to identify receptors involved. Furthermore, berberineon opioid expression established...
Peroxisome proliferator-activated receptor gamma (PPARγ), a critical nuclear receptor, plays pivotal role in regulating metabolic and inflammatory processes. However, various environmental contaminants can disrupt PPARγ function, leading to adverse health effects. This study introduces novel approach predict the inhibitory activity (IC50 values) of 140 chemical compounds across 13 categories, including pesticides, organochlorines, dioxins, detergents, flame retardants, preservatives, on...
Schwannomas are tumors arising from the nervous system that also occur infrequently in gastrointestinal tract, most commonly stomach. This report characterizes 29 patients with benign or malignant gastric schwannomas. Surgical data and clinical follow-up information were available for 28 cases a median postoperative duration of 57 months. Clinicopathological immunohistochemical characteristics schwannomas analysed. Four (13.7%) histologically diagnosed schwannoma. All positive S-100 CD56...
Background Hospital readmission is gathering increasing attention as a measure of health care quality and potential cost-saving target. The purpose this prospective study was to determine risk factors for within 30 days discharge after gastrectomy patients with gastric cancer. Methods We conducted undergoing radical cancer from October 2013 November 2014 in our institution. incidence, cause 30-day were determined. Results A total 376 included analysis without loss follow-up. rate 7.2% (27of...
Abstract Activation of the aryl hydrocarbon receptor (AhR) by immunosuppressive ligands promotes development regulatory T (Treg) cells. Although AhR‐induced Foxp3 + Treg cells have been well studied, much less is known about and fate Type 1 (AhR‐Tr1) In current study, we identified unique transcriptional functional changes in murine CD4 that accompany differentiation AhR‐Tr1 during T‐cell‐dependent phase an allospecific cytotoxic lymphocyte (allo‐CTL) response. AhR activation increased...
Sarcopenia, featured by the progressive loss of skeletal muscle function and mass, is associated with impaired stem cells (MuSCs) caused increasing oxidative stress in senescent tissue during aging. Intact MuSCs maintains regenerative potential as well homeostasis tissues Ginsenoside Rb1, a natural compound from ginseng, exhibited effects antioxidation against apoptosis. However, its restoring MuSC aging improving age-related sarcopenia remained unknown. In this study, we investigated role...
Berberine, an isoquinoline alkaloid derived from many medicinal plants, has been extensively used to treat various gastrointestinal diseases. In the present study, we investigated whether berberine could ameliorate intestinal mucosal barrier damage induced by peritoneal air exposure for 3 h. Peritoneal air-exposure rats received 100, 150, and 200 mg/kg orally via gavage four times before after surgery. Blood terminal ileum samples were collected 24 h The serum D-lactate levels determined...