A5101808832- Pancreatitis Pathology and Treatment
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Enhanced Recovery After Surgery
- Respiratory Support and Mechanisms
- Pancreatic and Hepatic Oncology Research
- Cardiac Ischemia and Reperfusion
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Abdominal Surgery and Complications
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Nutrition and Health in Aging
- Anesthesia and Neurotoxicity Research
- Gallbladder and Bile Duct Disorders
- Dermatological and COVID-19 studies
- Streptococcal Infections and Treatments
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Abdominal Trauma and Injuries
- Berberine and alkaloids research
- Hemodynamic Monitoring and Therapy
- Pediatric Hepatobiliary Diseases and Treatments
- Clinical Nutrition and Gastroenterology
- Organ Transplantation Techniques and Outcomes
Nanjing Drum Tower Hospital
2018-2024
Nanjing Medical University
2013-2022
Nanjing University
2011-2020
Nanjing General Hospital of Nanjing Military Command
2010-2019
Jinling Institute of Technology
2004-2017
Hebei University of Technology
2017
KU Leuven
2011
Objectives: A clinical study was made to test the hypothesis that gut mucosal damage happens and correlates with endotoxemia, systemic inflammation, severity of disease, septic complication, outcome in acute pancreatitis (AP) patients. Methods: Patients were divided into 3 groups according severity: grade 1 (n = 26, mild), 2 18, severe AP [SAP] without organ dysfunction), SAP dysfunction). Twenty healthy volunteers enrolled as control group. The intestinal lactulose mannitol absorption...
Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction that occurs secondary to infection in the body without overt central nervous system (CNS) infection. SAE frequently encountered critically ill patients intensive care units and can be detected up 50-70% of septic patients. Previous studies have demonstrated inflammatory cytokine release oxidative stress injury are major pathophysiological mechanisms However, there no effective strategies for treatment SAE. Insulin has...
Abstract Background Extra-Corporeal Membrane Oxygenation (ECMO) therapy is associated with high risk of neurologic injury. But the mechanism injury during and/or after ECMO still unclear. Recent animal experiments confirmed that treatment increases immune inflammatory response. The aim this study to investigate effect VV- on response cerebral tissues and neurological impairment. Methods 18 porcine were randomly divided into control, sham group (n = 6/group). was run 24 h in group, serum...
Pulmonary changes in veno-venous extracorporeal membrane oxygenation (VV-ECMO) are rarely determined. We compared the contribution of VV-ECMO and cannulation based on observation pulmonary inflammatory reaction parenchymal construction a porcine model low tidal volume (VT) ventilation. also evaluated effect adding continuous renal replacement therapy (CRRT) to ECMO circuit, because CRRT is known reduce systemic cytokine release induced by VV-ECMO. A total 18 pigs undergoing low-VT...
Berberine (BBR) has been shown to attenuate the deleterious effects of ischemia/reperfusion (I/R) injury in brain. We evaluated BBR on intestinal tight junction (TJ) changes during mesenteric I/R. I/R was induced rats by occlusion superior artery and reperfusion. The were randomized into four groups: control, BBR, I/R, + BBR. Intestinal permeability determined lactulose/mannitol test. ileum colon harvested assess mucosal inducible nitric oxide synthase activity. TJ ultrastructure studied...
Objective To learn the clinical outcome of percutaneous catheter drainage (PCD) for patients with infective pancreatic necrosis and possible influencing factors. Methods A retrospective review medical records who received PCD as first choice treatment in recent 2 years. The were divided into groups: (1) success group (2) alteration group. Characteristics, complications, process compared. Results In this study, 19 34 cured by alone (55.9%), whereas open necrosectomy needed 15 (44.1%). Between...
Ginsenoside Rb1 (GRb1), one of the principle active components Panax ginseng, has been reported to reduce inflammation in various diseases. In present study, we investigated whether GRb1 an anti-inflammatory effect on postoperative ileus (POI) and further contributes recovery gastrointestinal motility. POI was induced rats by intestinal manipulation. The received 5, 10 20 mg/kg orally via gavage four times before after surgery. Gastrointestinal motility assessed charcoal transport. Systemic...
Berberine, an isoquinoline alkaloid derived from many medicinal plants, has been extensively used to treat various gastrointestinal diseases. In the present study, we investigated whether berberine could ameliorate intestinal mucosal barrier damage induced by peritoneal air exposure for 3 h. Peritoneal air-exposure rats received 100, 150, and 200 mg/kg orally via gavage four times before after surgery. Blood terminal ileum samples were collected 24 h The serum D-lactate levels determined...
The optimal transfusion protocol remains unknown in the trauma setting. This retrospective cohort study aimed to determine if goal-directed based on standard thrombelastography (TEG) is feasible and beneficial patients with abdominal trauma.Sixty adult who received 2 or more units of red blood cell within 24 hours admission were studied. Patients managed via TEG (goal-directed group) compared admitted before utilization (control group).There 29 group 31 control group. Baseline parameters...
Abstract Background Extracorporeal membrane oxygenation (ECMO) has been recommended for the treatment of patients with acute, potentially reversible, life-threatening respiratory failure which unresponsive to conventional therapy. But it is unclear about how ECMO affects renal tissue. Methods Twenty-four piglets weighing 25 32 kg were used in this experiment. The randomly allocated 4 groups 6 animals each: sham group (S group), control (C VV-ECMO (E combined CRRT (EC group). sacrificed and...
Abstract Extracorporeal membrane oxygenation ( ECMO ) therapy can result in systemic immune inflammation and trigger a hemolytic response, both of which lead to oxidative stress injury. However, currently, there are few studies about whether The objective this study was determine the effect on stress. Twelve pigs were randomly divided into control treatment groups. Blood samples collected at −1, 0, 2, 6, 12, 24 h during order measure levels various markers plasma. All animals included...
Extracorporeal membrane oxygenation (ECMO) has been recommended for treatment of acute, potentially reversible, life-threatening respiratory failure unresponsive to conventional therapy. Intestinal mucosal barrier dysfunction is one the most critical pathophysiological disorders during ECMO. This study aimed determine whether combination with CRRT could alleviate damage intestinal function VV ECMO in a porcine model. Twenty-four piglets were randomly divided into control(C), sham(S), ECMO(E)...
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a worldwide pandemic named disease 2019 (COVID-19). The progression and mortality rates of patients with COVID-19 are higher in males than females. Hence, we explored the potential mechanism gender disparity searched for alternative therapeutic agents as unmet medical needs male COVID-19.Methods: We collected clinical data from 1339 analyzed androgen receptor (AR) chromatin binding expression patterns by ChIP-seq...
Background. Damage of the intestinal mucosa barrier may result in bacterial and endotoxin translocation, leading to local systemic inflammation. The present study was designed investigate whether peritoneal air exposure induces damage mucosal barrier. Methods. Sprague-Dawley rats (weighing 210 230 g) were randomized into five groups (6/group): a control group, sham three with for 1, 2, 3 h, respectively. At 24 h after surgery, blood terminal ileum sampled. serum D-lactate levels determined...
It is unclear at present whether extracorporeal membrane oxygenation (ECMO) therapy can improve intestinal mucous barrier function through increased perfusion. The study establishes an animal model for post-traumatic acute respiratory distress syndrome (ARDS) and evaluates the effect of v-vECMO treatment on mucosal barrier. Pulmonary contusion combined with ischemia-reperfusion injury was induced in 30 piglets. animals were randomly divided into control, model, ECMO groups. Serum I-FABP,...