A5100740742- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Gut microbiota and health
- Enhanced Recovery After Surgery
- Diet and metabolism studies
- MicroRNA in disease regulation
- Infant Nutrition and Health
- Cancer-related molecular mechanisms research
- Trace Elements in Health
- Gastric Cancer Management and Outcomes
- Fatty Acid Research and Health
- Circular RNAs in diseases
- Inflammatory Bowel Disease
- Liver Disease and Transplantation
- Heavy Metal Exposure and Toxicity
- Esophageal and GI Pathology
- Immune Response and Inflammation
- Conducting polymers and applications
- Child Nutrition and Water Access
- Metabolism and Genetic Disorders
- GDF15 and Related Biomarkers
- Eicosanoids and Hypertension Pharmacology
- Electrolyte and hormonal disorders
- Abdominal Surgery and Complications
- Mosquito-borne diseases and control
Nanjing University
2014-2024
Nanjing Medical University
2014-2024
Nanjing General Hospital of Nanjing Military Command
2015-2024
Hebei General Hospital
2024
North China University of Science and Technology
2024
Columbia University Irving Medical Center
2024
Suzhou Yongding Hospital
2024
Central South University
2023
Harrison International Peace Hospital
2023
Southern Medical University
2015-2023
This study was aimed at determining potential effects of apple-derived pectin on weight gain, gut microbiota, barrier and metabolic endotoxemia in rat models diet-induced obesity. The rats received a standard diet (control; Chow group; n = 8) or high-fat (HFD; 32) for eight weeks to induce top 50th percentile weight-gainers were selected as induced obese rats. Thereafter, the group continued chow, randomly divided into two groups HFD (HF pectin-supplemented (HF-P six weeks. Compared HF...
The transfection potency of lipid nanoparticle (LNP) mRNA systems is critically dependent on the ionizable cationic component. LNP composed optimized lipids often display distinctive mRNA-rich "bleb" structures. Here, it shown that such structures can also be induced for LNPs containing nominally less active by formulating them in presence high concentrations pH 4 buffers as sodium citrate, leading to improved potencies both vitro and vivo. Induction bleb structure type buffer employed, with...
Prostate cancer (PCa) is the second leading cause of cancer-related death in American men and many PCa patients develop skeletal metastasis. Current treatment modalities for metastatic are mostly palliative with poor prognosis. Epidemiological studies indicated that receiving diabetic drug metformin have lower risk better prognosis, suggesting may antineoplastic effects. The mechanism by which acts as chemopreventive agent to impede initiation progression unknown. amplification c-MYC...
The effect of and optimal timing for initiating supplemental parenteral nutrition (SPN) remain unclear after major abdominal surgery patients in whom energy targets cannot be met by enteral (EN) alone.To examine the early (E-SPN) (day 3 surgery) or late (L-SPN) 8 on incidence nosocomial infections undergoing who are at high nutritional risk have poor tolerance to EN.A multicenter randomized clinical trial was conducted from April 1, 2017, December 31, 2018, general department 11 tertiary...
Abstract Background Malnutrition and subsequent alterations in body composition (BC), particularly sarcopenia, are common but not yet elucidated patients with inflammatory bowel disease (IBD); we aimed to detail the changes BC characteristics of co‐occurrence malnutrition sarcopenia IBD investigate its effect on quality life. Methods This study was a multicentre, prospective, observational involving four tertiary referral hospitals China. The following data were collected from consecutive...
Parenteral nutrition (PN) increases the risk of infection in patients with contraindication to enteral feeding. Paneth cells produce and secrete antimicrobial products that protect mucosa from pathogens. Their loss is associated increased host-pathogen interactions, mucosal inflammation, altered microbiome composition.We hypothesized PN reduces cell product expression, these changes would reduce bactericidal properties tissue secretions following cholinergic stimulation, increase...
Background Personalized and accurate survival risk prognostication remains a significant challenge in advanced pancreatic ductal adenocarcinoma (PDAC), despite extensive research on prognostic predictive markers. Patients with PDAC are prone to muscle loss, fat consumption, malnutrition, which is associated inferior outcomes. This study investigated the use of three-dimensional (3D) anthropometric parameters derived from computed tomography (CT) scans triglyceride glucose-body mass index...
Mesoporous activated carbons were prepared from coconut shells by the method of chemical activation with H 3 PO 4 .Effects main influence factors on yield and adsorption properties carbon studied via orthogonal experiments.Experimental results under optimum conditions as follows: was 36.90%;methylene blue 21.5 mL/0.1 g; iodine number 889.36 mg/g.The surface area 891 m 2 /g, determined BET method.Horvath-Kawazoe equations (H-K) density functional theory (DFT) introduced to analyze porous...
Compelling evidence demonstrates the crucial role of commensal microbiota in host physiology and detrimental effects its perturbations following antibiotic treatment. However, on intestinal mucosa antimicrobial molecules have not been elucidated systematically. Here, we investigate impacts antibiotic-induced depletion subsequent restoration murine mucosa. Our results demonstrate that leads to atrophy reduction molecules, including lysozyme, regenerating islet-derived protein 3 gamma...
Objective To learn the clinical outcome of percutaneous catheter drainage (PCD) for patients with infective pancreatic necrosis and possible influencing factors. Methods A retrospective review medical records who received PCD as first choice treatment in recent 2 years. The were divided into groups: (1) success group (2) alteration group. Characteristics, complications, process compared. Results In this study, 19 34 cured by alone (55.9%), whereas open necrosectomy needed 15 (44.1%). Between...
The dysbiosis of human microbiome has been proven to be associated with the development many diseases. Metagenome sequencing emerges as a powerful tool investigate effects on Identification gut markers abnormal phenotypes may facilitate feature selection for multiclass classification. Compared binary classifiers, classification models deploy more complex discriminative patterns. Here, we developed pipeline address challenging characterization multilabel samples. In this study, total 300...
<b><i>Objective:</i></b> To assess the incidence of hypermetabolism, defined as high resting energy expenditure, in severe sepsis ICU patients, and evaluate suitability excessive expenditure (REE) a risk factor their clinical outcome. <b><i>Methods:</i></b> In single-center, prospective, six-month observational study China, measured REE (MREE) was estimated daily using indirect calorimetry (IC) for first 5 days admission. The predicted (PREE)...
Patients with decompensated cirrhosis (DC) are prone to skeletal muscle loss, namely, sarcopenia, before liver transplantation (LT). While sarcopenia is reportedly associated adverse outcomes after LT, these findings limited owing mixed diseases and retrospective data. We investigated the association between 1-year overall survival (OS) in patients DC LT established validated a prediction model for postoperative OS based on sarcopenia.