A5063896470- Reconstructive Surgery and Microvascular Techniques
- Breast Implant and Reconstruction
- Reconstructive Facial Surgery Techniques
- Mesenchymal stem cell research
- Body Contouring and Surgery
- Wound Healing and Treatments
- Breast Cancer Treatment Studies
- Tissue Engineering and Regenerative Medicine
- Anatomy and Medical Technology
- Bone fractures and treatments
- Digital Imaging in Medicine
- Meta-analysis and systematic reviews
- Effects of Radiation Exposure
- Venous Thromboembolism Diagnosis and Management
- Facial Rejuvenation and Surgery Techniques
- Surgical site infection prevention
- Electrospun Nanofibers in Biomedical Applications
- Orthopedic Surgery and Rehabilitation
- Body Image and Dysmorphia Studies
- Nerve Injury and Rehabilitation
- Organ and Tissue Transplantation Research
- Surgical Sutures and Adhesives
- Nonmelanoma Skin Cancer Studies
- Clinical practice guidelines implementation
- Surgical Simulation and Training
Stanford University
2016-2025
The University of Melbourne
2023-2025
Stanford Medicine
2015-2024
Palo Alto Institute
2013-2024
Palo Alto University
2017-2024
National Center for Advancing Translational Sciences
2023
American College of Surgeons
2023
Center For Reconstructive Urethral Surgery
2015-2023
W. L. Gore & Associates (Germany)
2023
University of British Columbia
2023
The transfection potency of lipid nanoparticle (LNP) mRNA systems is critically dependent on the ionizable cationic component. LNP composed optimized lipids often display distinctive mRNA-rich "bleb" structures. Here, it shown that such structures can also be induced for LNPs containing nominally less active by formulating them in presence high concentrations pH 4 buffers as sodium citrate, leading to improved potencies both vitro and vivo. Induction bleb structure type buffer employed, with...
Cell-assisted lipotransfer has shown much promise as a technique for improving fat graft take. However, the concentration of stromal vascular fraction cells required to optimally enhance retention remains unknown.Human lipoaspirate was processed both transfer and harvest cells. Cells were then mixed back with at varying concentrations ranging from 10,000 10 million per 200 μl fat. Fat volume assessed by means computed tomographic scanning over 8 weeks, grafts explanted compared...
With the growing relevance of artificial intelligence (AI)-based patient-facing information, microsurgical-specific online information provided by professional organizations was compared with that ChatGPT (Chat Generative Pre-Trained Transformer) and assessed for accuracy, comprehensiveness, clarity, readability.
Vitamin D–activated Trem2 + macrophages provide a novel strategy to develop advanced cell therapies for complex wounds.
Current direct air capture (DAC) technology is largely currently cost-prohibitive for large scale implementation due to the excessive energy required operate a combined absorption–desorption cycle. As desorption process consumes much of supplied energy, there demand find more sustainable sorbent materials that maintain high absorptive capacities yet can be regenerated at lower working temperatures. This work evaluates potassium glycinate (GlyK) as one such alternative absorbent. Through...
Purpose Systemic sclerosis (SSc) is a rare connective tissue disease associated with significant digital vasculopathy. Peripheral sympathectomy frequently offered late in the process after severe ischemia has already occurred patients being symptomatic for numerous years. The purpose of present study was to analyze results peripheral confirmed diagnosis SSc. Patients and methods A retrospective analysis 17 (26 hands) who underwent between January 2003 September 2013 performed. Data regarding...
Background: Evidence-based plastic surgery guidelines support the effectiveness of once-daily enoxaparin prophylaxis. Despite prophylaxis, one in 25 highest risk patients has a venous thromboembolism event. The authors examined pharmacodynamics standard doses to examine whether patient-level factors predict metabolism, inadequate dose predicts downstream events, and pharmacist-driven dose-adjustment protocol was effective. Methods: recruited adult who received postoperative at 40 mg/day....
Fat grafting has become increasingly popular for the correction of soft-tissue deficits at many sites throughout body. Long-term outcomes, however, depend on delivery fat in least traumatic fashion to optimize viability transplanted tissue. In this study, authors compare biological properties following injection using two methods.Lipoaspiration samples were obtained from five female donors, and cellular viability, proliferation, lipolysis evaluated either a modified Coleman technique or an...
Background: Radiation therapy is a mainstay in the treatment of many malignancies, but collateral damage to surrounding tissue, with resultant hypovascularity, fibrosis, and atrophy, can be difficult reconstruct. Fat grafting has been shown improve quality irradiated skin, volume retention graft significantly decreased. Deferoxamine U.S. Food Drug Administration–approved iron-chelating medication for acute iron intoxication chronic overload that also increase angiogenesis. The present study...
Background: The development of acellular dermal matrices has revolutionized implant-based breast reconstruction. most recent been the introduction prepectoral However, concerns have expressed related to quality soft-tissue coverage and infectious complications. Thus, authors felt it prudent perform a matched-pair analysis clinical outcomes following subpectoral tissue expander placement. Methods: A retrospective study patients who underwent immediate reconstruction by means (group 1)...
Capsular contracture remains a common complication after implant-based breast reconstruction. Previous work has suggested that the use of acellular dermal matrix (ADM) reduces rate capsular contracture, though little is understood about underlying mechanism. As myofibroblasts are believed to be key cells implicated in formation, we hypothesized ADM would result reduction periprosthetic myofibroblast concentration.Five patients who underwent immediate prepectoral tissue expander placement...
Radiation-induced skin injury is a well-known risk factor for impaired wound healing. Over time, the deleterious effects of radiation on produce fibrotic, hypovascular dermis poorly suited to Despite increasing understanding underlying pathophysiology, therapeutic options remain elusive. Deferoxamine (DFO), an iron-chelating drug, has been shown in prior murine studies ameliorate radiation-induced as well improve healing outcomes various pathologic conditions when administered transdermally....
: Stable internal screw/plating systems for hand fractures have evolved during the last 20 years. The improved versatility leads to increased use of these materials in open fractures, with benefit early mobilization. aim this retrospective study is discern whether broadening indications implants accompanied by complication rates.: Data from 365 patients treated 10 years at our department metacarpal or phalangeal stable fixation screw plate were gathered and analyzed.: Uneventful bony...
Purpose This study was conducted to investigate the correlation between number of vascularized lymph nodes (LN) transferred and resolution hind limb lymphedema in a rat model. Methods Unilateral created 18 male Sprague–Dawley rats following inguinal popliteal LN resection radiation. A para‐aortic flap based on celiac artery subsequently affected groin. The three groups consisted Group (no transfer), B (transfer single LN), C LNs). Volumetric analysis bilateral limbs performed using micro‐CT...