A5020973365- Mesenchymal stem cell research
- Body Contouring and Surgery
- Breast Implant and Reconstruction
- Wound Healing and Treatments
- Orthopedic Surgery and Rehabilitation
- Digital Imaging in Medicine
- Reconstructive Surgery and Microvascular Techniques
- Bone fractures and treatments
- Diversity and Career in Medicine
- Peripheral Nerve Disorders
- Surgical Sutures and Adhesives
- Osteoarthritis Treatment and Mechanisms
- Global Health Workforce Issues
- Global Health and Surgery
- Tissue Engineering and Regenerative Medicine
- Organ and Tissue Transplantation Research
- Lower Extremity Biomechanics and Pathologies
- Orthopedic Infections and Treatments
- Patient-Provider Communication in Healthcare
- Lymphatic System and Diseases
- Body Image and Dysmorphia Studies
- Surgical Simulation and Training
- Periodontal Regeneration and Treatments
- Cancer-related molecular mechanisms research
- Reconstructive Facial Surgery Techniques
Stanford University
2015-2025
Massachusetts General Hospital
2024-2025
Harvard University
2024
Hue Central Hospital
2022
National Hospital of Pediatrics
2022
Stanford Medicine
2015-2021
Creative Commons
2020
Institute for Stem Cell Biology and Regenerative Medicine
2015-2017
Materials Science & Engineering
2017
Stanford Health Care
2015-2017
Cell-assisted lipotransfer has shown much promise as a technique for improving fat graft take. However, the concentration of stromal vascular fraction cells required to optimally enhance retention remains unknown.Human lipoaspirate was processed both transfer and harvest cells. Cells were then mixed back with at varying concentrations ranging from 10,000 10 million per 200 μl fat. Fat volume assessed by means computed tomographic scanning over 8 weeks, grafts explanted compared...
Radiation therapy is not only a mainstay in the treatment of many malignancies but also results collateral obliteration microvasculature and dermal/subcutaneous fibrosis. Soft tissue reconstruction hypovascular, irradiated recipient sites through fat grafting remains challenging; however, coincident improvement surrounding skin quality has been noted. Cell-assisted lipotransfer (CAL), enrichment with additional adipose-derived stem cells (ASCs) from stromal vascular fraction, shown to...
Background: Perilunate/lunate injuries are frequently misdiagnosed. We hypothesize that utilization of a machine learning algorithm can improve human detection perilunate/lunate dislocations. Methods: Participants from emergency medicine, hand surgery, and radiology were asked to evaluate 30 lateral wrist radiographs for the presence dislocation with without use algorithm, which was used label lunate. Human performance tool evaluated using sensitivity, specificity, accuracy, F1 score....
Abstract Human mesenchymal stem cells (MSCs) have recently become a focus of regenerative medicine, both for their multilineage differentiation capacity and excretion proregenerative cytokines. Adipose-derived (ASCs) are particular interest because abundance in fat tissue the ease harvest via liposuction. However, little is known about impact different liposuction methods on functionality ASCs. Here we evaluate abilities ASCs harvested third-generation ultrasound-assisted (UAL) device versus...
The choice to undergo mastectomy and breast reconstruction is a highly personal decision with profound psychosocial effects, ultimately, the between implant- autologous tissue-based should be made based on combination of factual information patient's values preferences. Unfortunately, patients undergoing surgery may experience regret. Decision aids promote patient involvement in making by not only providing standard about options, but also emphasizing comparative risks, benefits,...
Adipose-derived stem cells (ASCs) have been identified as a population of multipotent with promising applications in tissue engineering and regenerative medicine. ASCs are abundant fat tissue, which can be safely harvested through the minimally invasive procedure liposuction. However, there exist variety different harvesting methods, unclear impact on ASC potential. The aim this study was thus to compare functionality derived from common technique suction-assisted lipoaspiration (SAL) versus...
While surgical options exist to treat lymphedema after axillary lymph node dissection (ALND), the lymphatic microsurgical preventive healing approach (LYMPHA) has been introduced as a measure performed during primary surgery, thus avoiding morbidity associated with lymphedema. Here, we highlight details of our operative technique and review postoperative outcomes. For patients, limb measurements body composition analyses were pre- postoperatively. Intraoperatively, reverse mapping was...
The superior gluteal artery perforator (SGAP) flap is a useful technique for breast reconstruction. This allows the transfer of patient's own skin and subcutaneous tissue with minimal donor-site morbidity. Despite its usefulness, SGAP not widely used among reconstructive surgeons. challenging dissection need microsurgery may contribute to reluctant use by many ability perform single-stage reconstruction buttock when abdominal or thigh are unavailable provides significant service patient...
Clinical translation of cell-based strategies for tissue regeneration remains challenging because survival implanted cells within hostile, hypoxic wound environments is uncertain. Overexpression B-cell lymphoma 2 (Bcl-2) has been shown to inhibit apoptosis in cells. The present study describes an "off the shelf" prefabricated scaffold integrated with magnetic nanoparticles (MNPs) used upregulate Bcl-2 expression adipose-derived stromal bone regeneration. Iron oxide cores were sequentially...
Reconstruction of soft tissue defects has traditionally relied on the use grafts and flaps, which may be associated with variable resorption and/or significant donor site morbidity. Cell-based strategies employing adipose-derived stromal cells (ASCs), found within vascular fraction (SVF) adipose tissue, offer an alternative strategy for reconstruction. In this study, we investigated potential a bone morphogenetic protein receptor type 1A (BMPR1A)(+) subpopulation ASCs to enhance de novo...
In Brief OBJECTIVE: To assess the cost-effectiveness of diagnostic laparoscopy, computed tomography (CT), and magnetic resonance imaging (MRI) after indeterminate ultrasonography in pregnant women with suspected appendicitis. METHODS: A decision-analytic model was developed to simulate appendicitis during pregnancy taking into consideration health outcomes for both developing fetuses. Strategies included CT, MRI. Outcomes positive appendectomy, negative maternal perioperative complications,...
Summary: Delayed or missed diagnosis of perilunate lunate dislocations can lead to significant morbidity. Advances in computer vision provide an opportunity improve diagnostic performance. In this study, a deep learning algorithm was used for detection and on lateral wrist radiographs. A total 435 radiographs were labeled as normal pathologic (perilunate dislocation). The each radiograph segmented with rectangular bounding box. Images partitioned into training test sets. Two neural networks,...
Carpal tunnel release is one of the most common surgical procedures performed by hand surgeons. The authors created a simulation open carpal utilizing mobile and rehearsal platform app. This study was in order to validate simulator as an effective training for release.The evaluated using number metrics: construct validity (the ability identify variability skill levels), face perceived teach intended material), content (that accurate representation operation), acceptability (willingness...
Adipose-derived stromal cells represent a relatively abundant source of multipotent cells, with many potential applications in regenerative medicine. The present study sought to demonstrate the use RNA sequencing identifying differentially expressed transcripts, particularly long noncoding RNAs, associated adipogenic differentiation gain clearer picture mechanisms responsible for directing adipose-derived cell fate toward lineage.Human were cultured media, and was harvested at days 0, 1, 3,...
The use of the transversus abdominis plane (TAP) block is increasing in abdominally based autologous tissue breast reconstruction as a method to provide postoperative donor site analgesia. purpose this study was evaluate efficacy TAP immediate period.A retrospective analysis all patients who underwent microsurgical over 2-year period (2013-2015) conducted. Only with an abdominal were included. Patients grouped on presence or absence blocks. Primary endpoints included patient-reported pain...
Background: Because of the abundance and biocompatibility fat, lipotransfer has become an attractive method for treating soft-tissue deficits. However, it is limited by unpredictable graft survival retention. Currently, little known about viscoelastic properties fat after various injection methods. Here, authors assess effects cannula diameter, length, shape on properties, structure, retention fat. Methods: Human lipoaspirate was harvested using suction-assisted liposuction prepared...
Abstract Synovial fluid (SF) is a viscous ultrafiltrate of plasma that lubricates articulating joint motion. During acute trauma and certain cartilage repair procedures, blood introduced into the mixes with variable amounts SF. The hypothesis this study was dilution SF alters rheological properties mechanical clot formed. objectives were to determine composition (solid fraction, protein content), coagulation (fibrin polymerization time, torsional strength), (stiffness, permeability) mixtures...