A5100395958- Antibiotic Resistance in Bacteria
- Cytokine Signaling Pathways and Interactions
- Bacterial Genetics and Biotechnology
- Cancer, Stress, Anesthesia, and Immune Response
- Organoselenium and organotellurium chemistry
- RNA and protein synthesis mechanisms
- Cancer Cells and Metastasis
- Antibiotics Pharmacokinetics and Efficacy
- Sulfur Compounds in Biology
- Immune Response and Inflammation
- Redox biology and oxidative stress
- Pharmacological Effects of Natural Compounds
- Pharmaceutical and Antibiotic Environmental Impacts
- Cancer Mechanisms and Therapy
- Phytochemical and Pharmacological Studies
- Bacteriophages and microbial interactions
- Genetic Associations and Epidemiology
- Advanced Decision-Making Techniques
- Galectins and Cancer Biology
- Bioactive natural compounds
- Enzyme Structure and Function
- High Altitude and Hypoxia
- Traditional Chinese Medicine Analysis
- IL-33, ST2, and ILC Pathways
- Neuropeptides and Animal Physiology
Wuhan Polytechnic University
2024
Qingdao Agricultural University
2020-2024
China Three Gorges University
2012-2023
Yichang Central People's Hospital
2020-2023
Zhejiang Gongshang University
2011-2023
Tianjin Medical University
2023
Nankai University
2023
Tianjin Third Central Hospital
2023
82th Hospital of Pla
2020-2022
Gansu University of Traditional Chinese Medicine
2022
An increasing amount of evidence indicates that the inhibition β adrenergic signaling can result in tumor growth. However, role propranolol liver cancer and underlying mechanism remain to be elucidated. The present study aimed investigate cell lines provide for further clinical study. Propranolol was added at different concentrations HepG2 HepG2.2.15 cells HL‑7702 normal human cells. proliferation monitored by live‑cell imaging a range time intervals. Immunofluorescence using DAPI Hoechst...
As a thiol-dependent enzyme, thioredoxin reductase (TrxR) is promising antibacterial drug target. Ebselen, an organo-selenium with well-characterized toxicology and pharmacology, was recently reported to have potent activity against Staphylococcus aureus. In this paper, we demonstrated that ebselen has strong bactericidal multidrug-resistant (MDR) S. aureus based on taking TrxR as major target disruption of the redox microenvironment. Further, topical therapeutic efficacy for staphylococcal...
Polymeric coatings that combine resistance to adhesion ("defending") and killing ("attacking") of biocontaminants were proposed endow the surface with nonadhesive bactericidal capabilities. In contrast, a zwitterionic copolymer P(GMA-co-DMAPS) antifouling groups ([2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide, DMAPS) zwitterionic/cationic P(GMA-co-DMAPS-co-DMC) ([2-(methacryloyloxy)ethyl]trimethylammonium chloride, DMC) synthesized, which latter exhibited synergistic...
Abstract Objectives To develop and validate a contrast-enhanced MRI-based intratumoral heterogeneity (ITH) model for predicting lymph node (LN) metastasis in resectable pancreatic ductal adenocarcinoma (PDAC). Methods Lesions were encoded into different habitats based on enhancement ratios at arterial, venous, delayed phases of MRI. Habitat models enhanced ratio mapping single sequences, radiomic models, clinical developed evaluating LN metastasis. The performance the was evaluated via...
Exponential smoothing model is one of the main load forecasting models power systems, accuracy depends on coefficient. In this paper, a study how to seek best coefficient given. The results show that using principle weighting more near data and less far optimal can get better result. Based result, method weight proposed. A practical example with also shown here.
Compelling evidence demonstrates the crucial role of commensal microbiota in host physiology and detrimental effects its perturbations following antibiotic treatment. However, on intestinal mucosa antimicrobial molecules have not been elucidated systematically. Here, we investigate impacts antibiotic-induced depletion subsequent restoration murine mucosa. Our results demonstrate that leads to atrophy reduction molecules, including lysozyme, regenerating islet-derived protein 3 gamma...
YidC depletion affects membrane protein insertion and leads to a defect in the growth of Escherichia coli cell. We analyzed global changes gene expression upon determine importance for cellular functions using chip method compare transcriptomes JS71 (control) JS7131 (yidC strain). Of more than 4,300 genes identified, 163 were upregulated 99 downregulated depletion, including which are responsible DNA/RNA repair; energy metabolism; various transporters, proteases chaperones; stress response;...
Synergistic effects of phages in combination with antibiotics have received increasing attention. In this present study, we isolated a new phage pB3074 against clinically multidrug-resistant Acinetobacter baumannii. Phage combined cell wall-targeting could produce synergistic antibacterial effect vitro bactericidal activities. Further research indicates that the bacteriophage dose is critical to antimicrobial and antibiotic combination. Cefotaxime meropenem were selected as representative...
The maturation of eosinophils in bone marrow, their migration to pulmonary tissue, and subsequent degranulation release toxic granule proteins contributes the pathophysiology observed asthma. Interleukin-5 (IL-5) is essential for these processes occur. Therefore, much emphasis has been placed on attempts inhibit production or activity IL-5 order attenuate inflammatory aspect In this report, immunological consequences long-term exposure an antibody recognizing (TRFK-5) were studied a murine...
Summary The significance of loss SOCS 3, a negative regulator signalling pathways including those STAT 3 and NF ‐κ B , was examined in mantle cell lymphoma ( MCL ). protein expression gene methylation status were detected using immunohistochemistry/ W estern blots methylation‐specific polymerase chain reaction, respectively. To evaluate its functional importance, restored two 3‐negative lines lentiviral vector. Loss found 3/4 18/33 (54·5%) tumours. SOCS3 consistently methylated (3/4) tumours...
Abstract Ebselen (EbSe), an organo-selenium compound with well-characterized toxicology and pharmacology, exhibited potent antibacterial activity against glutathione (GSH)-positive bacteria when combined silver ions (Ag+). In this paper, the strong bactericidal of EbSe–Ag+ multidrug-resistant (MDR) Acinetobacter baumannii has been confirmed, its efficacy was mainly based on inhibition thioredoxin reductase (TrxR) depletion total GSH amount. Moreover, therapeutic effect urinary tract...