A5101913385- Genomics and Phylogenetic Studies
- Cancer Genomics and Diagnostics
- Microbial Community Ecology and Physiology
- Advanced biosensing and bioanalysis techniques
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Aquaculture disease management and microbiota
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Probiotics and Fermented Foods
- Bacteriophages and microbial interactions
- Cancer Mechanisms and Therapy
- Energy, Environment, Economic Growth
- Genomics and Rare Diseases
- Blood transfusion and management
- Cholesterol and Lipid Metabolism
- Limits and Structures in Graph Theory
- Pharmaceutical and Antibiotic Environmental Impacts
- DNA and Biological Computing
- Cancer, Hypoxia, and Metabolism
- Chromatography in Natural Products
- Machine Learning in Healthcare
- Security and Verification in Computing
- Natural product bioactivities and synthesis
- Salivary Gland Disorders and Functions
North Sichuan Medical University
2023-2024
Zigong First People's Hospital
2024
First Affiliated Hospital of Wenzhou Medical University
2022-2024
Wenzhou Medical University
2022-2024
Huashan Hospital
2024
Fudan University
2024
State Key Laboratory of Medical Neurobiology
2024
China Pharmaceutical University
2023-2024
Princeton University
2023
State Key Laboratory of Natural Medicine
2023
Osteosarcoma, a primary malignant bone tumour prevalent among adolescents and young adults, remains considerable challenge despite protracted progress made in enhancing patient survival rates over the last 40 years. Consequently, development of novel therapeutic approaches for osteosarcoma is imperative. Sanguinarine (SNG), compound with demonstrated potent anticancer properties against various malignancies, presents promising avenue exploration. Nevertheless, intricate molecular mechanisms...
Atherosclerosis is a major pathology for cardiovascular diseases (CVDs). Clinically, the intermittent fasting (IF) has been observed to reduce risk of CVDs. However, effect IF on development atherosclerosis not fully elucidated. Herein, we determined protection against high-fat diet-induced in pro-atherogenic low-density lipoprotein receptor deficient (LDLR-/-) mice and potentially involved mechanisms. The LDLR-/- were scheduled cycles 3-day HFD feeding ad libitum 1 day fasting, while...
JavaScript engines have been shown prone to security vulnerabilities, which can lead serious consequences due their popularity. Fuzzing is an effective testing technique discover vulnerabilities. The main challenge of fuzzing generate syntactically and semantically valid inputs such that deep functionalities be explored. However, the dynamic nature special features different engines, it quite challenging meaningful test inputs.
Microsatellite instability (MSI) is a promising biomarker for cancer prognosis and chemosensitivity. Techniques are rapidly evolving the detection of MSI from tumor-normal paired or tumor-only sequencing data. However, tumor tissues often insufficient, unavailable, otherwise difficult to procure. Increasing clinical evidence indicates enormous potential plasma circulating cell-free DNA (cfNDA) technology as noninvasive approach.We developed MSIsensor-ct, bioinformatics tool based on machine...
Climatic changes and environmental pollution caused by traditional urban development models have increased due to accelerated urbanisation industrialisation. As a new model of development, smart city construction relies on digital technology reform achieve intelligent governance, which is crucial for reducing carbon emission intensity achieving regional green development. This paper constructs multi-period DID based panel data from 283 cities 2007 2019 explore the impact intensity. study...
Cancer patients have a higher risk of depression and are associated with severe adverse prognosis. The relationship between leisure-time physical activity (LTPA) depressive symptoms in cancer is currently unclear. Therefore, our study mainly explores the potential association LTPA weekly cumulative time patients.
Objectives: Esophageal squamous cell carcinoma is a highly prevalent cancer withpoor survival rate and prognosis. Increasing evidence suggests an important role for metabolic regulation in treating esophageal carcinoma, but the underlying mechanism remains unclear. The pyruvate kinase M2 isoform key enzyme energy production process, upregulation of also plays crucial gene transcription tumorigenesis. mammalian target rapamycin pathway regulates array cellular functions, including protein...
Next-generation sequencing (NGS) technology has revolutionised human cancer research, particularly via detection of genomic variants with its ultra-high-throughput and increasing affordability. However, the inundation rich genomics data resulted in significant challenges exploration translation into biological insights. One difficulties genome is software selection. Currently, multiple tools are widely used to process NGS four stages: raw sequence pre-processing quality control (QC),...
HotSpot3D is a widely used software for identifying mutation hotspots on the 3D structures of proteins. To further assist users, we developed new web server to make this more versatile, convenient and interactive.The performs data pre-processing, clustering, visualization log-viewing one stop. Users can interactively explore each cluster easily re-visualize mutational clusters within browsers. We also provide database that allows users search visualize proximal mutations from 33 cancers in...
The accelerating growth of the public microbial genomic data imposes substantial burden on research community that uses such resources. Building databases for non-redundant reference sequences from massive based clustering analysis is essential. However, existing algorithms perform poorly long sequences. In this article, we present Gclust, a parallel program complete or draft sequences, where accelerated with novel parallelization strategy and fast sequence comparison algorithm using sparse...
Three prokaryotic predator strains, BL9T, BL10 and BL28, were isolated with Vibrio alginolyticus from coastal seawater of PR China. Cells the strains Gram-negative, vibrioid-shaped motile a single sheathed flagellum (25-28 nm wide). around 0.3×0.5-1.0 µm in size. The three obligate predators that exhibited biphasic life cycle: free-swimming attack phase an intraperiplasmic growth within prey. Bdelloplasts formed. NaCl was required for growth. Optimum occurred at ~37 °C, 2-4 % (w/v) pH...
The deletion distance between two binary words <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$u,v \in \{0,1\}^{n}$ </tex-math></inline-formula> is the smallest notation="LaTeX">$k$ such that notation="LaTeX">$u$ and notation="LaTeX">$v$ share a common subsequence of length notation="LaTeX">$n-k$ . A set notation="LaTeX">$C$ notation="LaTeX">$n$ called -deletion code if every pair distinct in has greater...
Internal tandem duplication (ITD) of FMS-like tyrosine kinase 3 (FLT3-ITD) constitutes an independent indicator poor prognosis in acute myeloid leukaemia (AML). AML with FLT3-ITD usually presents treatment outcomes, high recurrence rate and short overall survival. Currently, polymerase chain reaction capillary electrophoresis are widely adopted for the clinical detection FLT3-ITD, whereas length mutation frequency ITD evaluated using fragment analysis. With development sequencing technology...
CD38 is a transmembrane glycoprotein that relatively highly expressed on multiple myeloma (MM) cells, and CD38-targeting antibodies use pleiotropic mechanisms to kill MM cells. Immunotherapy, with an increased quality of response acceptable toxicity, shows tremendous potential for treating MM. This research field study aimed analyze all the relevant literature via bibliometrics identify its course development structural relationships.A total 1,030 articles were retrieved from Web Science...
Two C24 epimeric 3-acetylated ocotillol-type sapogenins, 20 R,24 S-epoxy-dammarane-3β,12β,25-triol acetate and R-epoxy-dammarane-3β,12β,25-triol have been achieved from 20( R)-protopanaxadiol. Their structures were confirmed by HRMS, 1 H NMR, 13 C NMR single crystal X-ray diffraction which showed that their configurations (20 R, 24 S) R), respectively. In the structure of ( S)-epimer, there two intramolecular hydrogen bonds a left-handed helical chain whilst in R)-epimer was one bond...