A5010521122- Complex Systems and Decision Making
- Environmental Justice and Health Disparities
- scientometrics and bibliometrics research
- Parasite Biology and Host Interactions
- Telomeres, Telomerase, and Senescence
- Genetics, Aging, and Longevity in Model Organisms
- Zoonotic diseases and public health
- Genomics, phytochemicals, and oxidative stress
- Parasites and Host Interactions
- Carcinogens and Genotoxicity Assessment
- Species Distribution and Climate Change
- Coal and Its By-products
- DNA Repair Mechanisms
- Arsenic contamination and mitigation
- Data Analysis with R
- DNA and Nucleic Acid Chemistry
Emory University
2021-2024
National Heart Lung and Blood Institute
2018
National Institutes of Health
2018
Oregon State University
2017
Senescent cells contribute to age-related pathology and loss of function, their selective removal improves physiological function extends longevity. Rapamycin, an inhibitor mTOR, inhibits cell senescence in vitro increases longevity several species. Nrf2 levels have been shown decrease with aging silencing gene induces premature senescence. Therefore, we explored whether is involved the mechanism by which rapamycin delays In wild-type (WT) mouse fibroblasts, increased Nrf2, this correlates...
Significance Predicting how ecological interactions among vectors or intermediate hosts of human parasites influence transmission potential to humans remains challenging. Here, we focus on schistosomiasis and demonstrate resource competition snails profoundly alters the link between infected snails, target control, schistosome cercariae, cause infections. We integrated an individual-based bioenergetics model snail dynamics with experiments in artificial waterbodies field observations...
Fanconi Anemia (FA) is characterized by bone marrow failure, congenital abnormalities, and cancer. Of over 20 FA-linked genes, FANCJ uniquely encodes a DNA helicase mutations are also associated with breast ovarian fancj-/- cells sensitive to interstrand cross-linking (ICL) replication fork stalling drugs. We delineated the molecular defects of two FA patient-derived domain mutations. FANCJ-R707C was compromised in dimerization processivity, whereas unwinding FANCJ-H396D barely detectable....
Abstract Models have become a key component of scientific hypothesis testing and climate sustainability planning, as enabled by increased data availability computing power. As result, understanding how the perceived ‘complexity’ model corresponds to its accuracy predictive power has prevalent research topic. However, wide variety definitions complexity been proposed used, leading an imprecise what is consequences across studies, study systems, disciplines. Here, we propose more explicit...
In 2019, an estimated 20% of the energy produced in Georgia came from coal power plants, producing a staggering 6 million tons toxic ash byproducts (Nuclear Energy Institute 2020). The improper storage this leads to chemicals leaching into environment, poisoning people who reside near plants and dump sites (Earth Justice 2018). Both nation here Georgia, Black African American communities are disproportionately harmed by health issues caused exposure due living (Merem 2016, 1-16). To ensure...