A5037984928- Synthesis and biological activity
- DNA Repair Mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Computational Drug Discovery Methods
- DNA and Nucleic Acid Chemistry
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Synthesis and Biological Evaluation
- RNA and protein synthesis mechanisms
- Metal complexes synthesis and properties
- Melanoma and MAPK Pathways
- Oil and Gas Production Techniques
- Reservoir Engineering and Simulation Methods
- Nanoparticles: synthesis and applications
- Hydraulic Fracturing and Reservoir Analysis
- Synthesis of heterocyclic compounds
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Quinazolinone synthesis and applications
- Biochemical and Molecular Research
- Protein Tyrosine Phosphatases
- Diverse Scientific Research Studies
- Advanced biosensing and bioanalysis techniques
- Click Chemistry and Applications
- Gout, Hyperuricemia, Uric Acid
Guru Ghasidas Vishwavidyalaya
2014-2024
National Research Centre on Yak
2023
Chaudhary Sarwan Kumar Himachal Pradesh Krishi Vishvavidyalaya
2023
Bihar Agricultural University
2023
Birsa Agricultural University
2023
Aligarh Muslim University
2022
Netaji Subhash Chandra Bose Medical College
2021
National Institute on Aging
2012-2020
ES Technology (United Kingdom)
2020
National Institutes of Health
2012-2018
G-quadruplex (G4) DNA, an alternate structure formed by Hoogsteen hydrogen bonds between guanines in G-rich sequences, threatens genomic stability perturbing normal DNA transactions including replication, repair, and transcription. A variety of G4 topologies (intra- intermolecular) can form vitro, but the molecular architecture cellular factors influencing landscape vivo are not clear. Helicases that unwind structured molecules emerging as important class G4-resolving enzymes. The...
Cockayne syndrome is a neurodegenerative accelerated aging disorder caused by mutations in the CSA or CSB genes. Although pathogenesis of has remained elusive, recent work implicates mitochondrial dysfunction disease progression. Here, we present evidence that loss neuroblastoma cell line converges on defects ribosomal DNA transcription and activation damage sensor poly-ADP ribose polymerase 1 (PARP1). Indeed, inhibition leads to number lines. Furthermore, machine-learning algorithms predict...
Mutations in the gene encoding iron–sulfur-containing DNA helicase DDX11 (ChlR1) were recently identified as a cause of new recessive cohesinopathy, Warsaw breakage syndrome (WABS), single patient with severe microcephaly, pre- and postnatal growth retardation, abnormal skin pigmentation. Here, using homozygosity mapping Lebanese consanguineous family followed by exome sequencing, we novel homozygous mutation (c.788G>A [p.R263Q]) three affected siblings intellectual disability many...
We present evidence that Tim establishes a physical and functional interaction with DDX11, super-family 2 iron-sulfur cluster DNA helicase genetically linked to the chromosomal instability disorder Warsaw breakage syndrome. stimulates DDX11 unwinding activity on forked substrates up 10-fold bimolecular anti-parallel G-quadruplex structures three-stranded D-loop approximately 4–5-fold. Electrophoretic mobility shift assays revealed enhances binding DNA, suggesting observed stimulation derives...
Abstract As the powerhouses of eukaryotic cell, mitochondria must maintain their genomes which encode proteins essential for energy production. Mitochondria are characterized by guanine-rich DNA sequences that spontaneously form unusual three-dimensional structures known as G-quadruplexes (G4). G4 can be problematic processes replication and transcription because they deter normal progression enzymatic-driven processes. In this study, we addressed hypothesis mitochondrial is a source...