A5086999496- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Chromatin Remodeling and Cancer
- RNA regulation and disease
- Cancer, Lipids, and Metabolism
- Ovarian cancer diagnosis and treatment
- Musculoskeletal pain and rehabilitation
- Cancer Mechanisms and Therapy
- Spine and Intervertebral Disc Pathology
- Pregnancy-related medical research
- Melanoma and MAPK Pathways
- MicroRNA in disease regulation
- Cholesterol and Lipid Metabolism
- Testicular diseases and treatments
- Male Breast Health Studies
- Analytical Chemistry and Chromatography
- Urban Green Space and Health
- Synthesis and Reactions of Organic Compounds
- Peroxisome Proliferator-Activated Receptors
- Mechanisms of cancer metastasis
- Endometrial and Cervical Cancer Treatments
- Reproductive tract infections research
- Recreation, Leisure, Wilderness Management
- Epigenetics and DNA Methylation
Icahn School of Medicine at Mount Sinai
2022-2025
Sapienza University of Rome
2013-2025
Universidad de Navarra
2015-2024
Navarre Institute of Health Research
2016-2024
New York Proton Center
2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2024
ASST Fatebenefratelli Sacco
2020
University of Milan
1958-2020
Boston Children's Hospital
2014
Ospedale Maggiore
2012
It is now obvious that the majority of cellular transcripts do not code for proteins, and a significant subset them are long non-coding RNAs (lncRNAs). Many lncRNAs show aberrant expression in cancer, some have been linked to cell transformation. However, underlying mechanisms remain poorly understood it unknown how sequences lncRNA dictate their function. Here we characterize function p53-regulated human LINC-PINT cancer. We find downregulated multiple types cancer acts as tumor suppressor...
Recent small RNA sequencing data has uncovered 3′ end modification of mature microRNAs (miRNAs). This non-templated nucleotide addition can impact miRNA gene regulatory networks through the control stability or by interfering with repression target mRNAs. The modifying enzymes responsible for this regulation remain largely uncharacterized. Here we describe ability two related terminal uridyl transferases (TUTases), Zcchc6 (TUT7) and Zcchc11 (TUT4), to mono-uridylate a specific subset miRNAs...
LncRNAs have been shown to be direct players in chromatin regulation, but little is known about their role at active genomic loci. We investigate the of lncRNAs gene activation by profiling RNA interactome SMARCB1-containing SWI/SNF complexes proliferating and senescent conditions. The isolation SMARCB1-associated transcripts, together with profiling, shows prevalent association regions where SMARCB1 differentially binds locally transcribed RNAs. identify SWINGN, a lncRNA interacting...
ARID2 is the most recurrently mutated SWI/SNF complex member in melanoma; however, its tumor-suppressive mechanisms context of chromatin landscape remain to be elucidated. Here, we model deficiency melanoma cells, which results defective PBAF assembly with a concomitant genomic redistribution BAF complex. Upon depletion, subset and shared BAF-PBAF-occupied regions displays diminished accessibility associated gene expression, while BAF-occupied enhancers gain expression genes linked process...
Oral consumption of probiotics is practical and can be an effective solution to preserve vaginal eubiosis. Here, we studied the ability orally administered Lactobacillus paracasei LPC-S01 (DSM 26760) affect composition microbiota colonize mucosa in nondiseased adult women. A total 40 volunteers took oral probiotic (24 billion CFU) or placebo capsules daily for 4 weeks, after a 4-week washout, they switched according crossover design. 23 completed study protocol. Before capsule ingestion,...
Natural environments are known to foster positive emotions and well-being, while Virtual Reality (VR) represents a powerful tool explore such effects. This study investigates the restorative potential of virtual natural for emotional recovery, combining self-report physiological measures. Fifty-two participants were divided into three groups—formed spontaneously based on their preferred scenarios—and Neutral group—exposed neutral scenario. The results reveal that scenarios effectively...
High levels of H2A.Z promote melanoma cell proliferation and correlate with poor prognosis. However, the role two distinct histone chaperone complexes SRCAP P400–TIP60 in remains unclear. Here, we show that individual subunit depletion , P400 VPS72 (YL1) results not only loss deposition into chromatin but also a reduction H4 acetylation cells. This is particularly found at promoters cycle genes directly bound by its chaperones, suggesting coordinated regulation between to their expression....
Summary Multimeric SWI/SNF chromatin remodelers assemble into discrete conformations with unique complex functionalities difficult to dissect. Distinct cancers harbor mutations in specific subunits, altering the landscape, such as PBAF-specific component ARID2 melanoma. Here, we performed comprehensive epigenomic profiling of complexes and their associated states melanoma melanocytes uncovered a subset PBAF-exclusive regions that coexist PRC2 repressive chromatin. Time-resolved approaches...
Despite the classical view of senescence as passive growth arrest, it is an active process with profound implications for cellular homeostasis. Senescent cells remain metabolically to be able cope energetic demand program, although precise mechanisms underlying this metabolic reprogramming are just beginning emerge. Here we have identified sin-lncRNA, a previously uncharacterized lncRNA, highly specific senescent cells, and transcriptionally induced by C/EBPβ, master regulator...
Abstract Background Ovarian dysgerminomas are rare, malignant germ cell tumors primarily affecting young women. Conservative surgery sometimes followed by chemotherapy is the treatment of choice, particularly in patients with a strong desire to have pregnancies. during pregnancy exceedingly rare. In these cases, role tumor markers limited, as well after cancer, or cancers diagnosed immediately pregnancy. Moreover, post-partum anemia very common occurrence wide differential diagnosis,...
ABSTRACT Poor intervertebral disc (IVD) healing causes IVD degeneration (IVDD) and progression to herniation back pain. This study identified distinct roles of TNFα-receptors (TNFRs) in contributing poor painful IVDD. We first isolated IVDD tissue pain subjects determined the complex pro-inflammatory mixture contained many chemokines for recruiting inflammatory cells. Single-cell RNA-sequencing human tissues revealed these pro- cytokines were dominantly expressed by a small...