A5072378382- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Colorectal Cancer Treatments and Studies
- Carcinogens and Genotoxicity Assessment
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- DNA and Nucleic Acid Chemistry
- Cancer, Hypoxia, and Metabolism
- Cancer Treatment and Pharmacology
- Cancer Research and Treatments
- PARP inhibition in cancer therapy
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
- Microtubule and mitosis dynamics
- Spaceflight effects on biology
- Genomic variations and chromosomal abnormalities
- BRCA gene mutations in cancer
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Cancer therapeutics and mechanisms
- Gastric Cancer Management and Outcomes
- Plant Genetic and Mutation Studies
Fukuoka Dental College
2023-2024
Kyushu University
2015-2024
Kyoto University
1996-2017
National Hospital Organization Kyushu Cancer Center
2016-2017
Molecular Oncology (United States)
2008-2016
Kobe University
2016
National Sagamihara Hospital
2016
Nishikyushu University
2015
Hiroshima University
2007-2011
Kawasaki Medical School
2004-2007
MDMX, an MDM2-related protein, has emerged as yet another essential negative regulator of p53 tumor suppressor, since loss MDMX expression results in p53-dependent embryonic lethality mice. However, it remains unknown why neither homologue can compensate for the other. In addition, biochemical studies have suggested that inhibits MDM2-mediated degradation, thus contradicting its role defined gene knockout experiments. Using cells deficient either MDM2 or we demonstrated these two inhibitors...
Abstract The epidermal growth factor receptor (EGFR)–specific tyrosine kinase inhibitor gefitinib may provide dramatic clinical responses in some patients with pulmonary adenocarcinoma carrying activating mutations of the EGFR. However, prolonged administration eventually induce acquired resistance such patients. To gain insight into mechanisms this phenomenon, we placed PC-9, a cell line derived from that has 15-bp deletion EGFR exon 19, under continuous selective pressure low levels...
Although genetic studies have demonstrated that MDMX is essential to maintain p53 activity at low levels in non-stressed cells, it unknown whether regulates activation by DNA damage. We show here damage-induced induction associated with rapid down-regulation of the protein. Significantly, interference results suppression genotoxic stress. also demonstrate reduction mediated MDM2, which targets for proteasomal degradation a distinct mechanism permits preferential and therefore ensures optimal...
Recent studies show overlap between Fanconi anemia (FA) proteins and those involved in DNA repair mediated by homologous recombination (HR).However, the mechanism which FA affect HR is unclear.FA (FancA/C/E/F/G/L) form a multiprotein complex, responsible for damageinduced FancD2 monoubiquitination, key event cellular resistance to damage.Here, we that FANCD2-disrupted DT40 chicken B-cell line defective HR-mediated double-strand break (DSB) repair, as well gene conversion at immunoglobulin...
Immunohistochemistry staining of p53 is a cheap and simple method to detect aberrant function p53. However, there are some discrepancies between the result immunohistochemistry mutation analysis. This study attempted find new definition by its pattern. TP53 gene analysis were performed in 148 gastric cancer patients. Also SNP-CGH array was conducted four cases. Positive observed 88 (59.5%) tumors. Tumors with positive showed malignant features compared negative Mutation 29 (19.6%) tumors...
Trifluridine (FTD) is a key component of the novel oral antitumor drug TAS-102, which consists FTD and thymidine phosphorylase inhibitor. Like 5-fluoro-2'-deoxyuridine (FdUrd), deoxynucleoside form 5-fluorouracil metabolite, sequentially phosphorylated not only inhibits thymidylate synthase activity, but also incorporated into DNA. Although TAS-102 was effective for treatment refractory metastatic colorectal cancer in clinical trials, mechanism FTD-induced cytotoxicity completely understood....
Both internal and external oxidative stresses act on DNA can induce carcinogenesis. 8-hydroxydeoxyguanosine (8-OHdG) is an indicator of stress it leads to transversion mutations 8-OHdG excision-repaired by glycosylase (OGG1). The purpose this study clarify the effect damage repair enzymes esophageal levels OGG1 were immunohistochemically evaluated in resected specimens, including squamous cell carcinoma (SCC) 97 patients with cancer. Higher normal epithelium associated a higher smoking index...
Therapy-induced senescence (TIS) is a state of cell division arrest induced by chemotherapy that blocks tumor growth. TIS cells affect the microenvironment through their senescence-associated secretory phenotype and independently acquire stemness, which makes them more aggressive causes relapse once they regrow. To eradicate tumors chemotherapy, long-lived must be efficiently eliminated. Here, we show AZD5582 AT406, are potent antagonists inhibitor apoptosis proteins (IAP antagonists)...
BRCA2 is a tumor suppressor gene that linked to hereditary breast and ovarian cancer. Although the Brca2 protein participates in homologous DNA recombination (HR), its precise role remains unclear. From chicken DT40 cells, we generated gene-deficient cells which harbor truncation at 3' end of BRC3 repeat (brca2tr). Comparison characteristics brca2tr with those other HR-deficient clones revealed marked similarities rad51 paralog mutants (rad51b, rad51c, rad51d, xrcc2, or xrcc3 cells). The...
Gastric cancers show high frequency of DNA aneuploidy, a phenotype chromosomal instability. It is suggested that the abnormal spindle assembly checkpoint involved in but underlying mechanism still unclear. We studied by assessing expression BUBR1 gastric cancer. The ploidy patterns 116 cancer samples obtained from Department Surgery and Science at Kyushu University Hospital were analyzed. Of those, aneuploidy was seen 70 (60.3%) cases immunohistochemistry 181 real-time RT-PCR several cell...