A5065230795- Microtubule and mitosis dynamics
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Helicobacter pylori-related gastroenterology studies
- HER2/EGFR in Cancer Research
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Science, Research, and Medicine
- Hepatocellular Carcinoma Treatment and Prognosis
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Molecular Biology Techniques and Applications
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Heat shock proteins research
- Genomics and Chromatin Dynamics
- Mitochondrial Function and Pathology
- Liver physiology and pathology
- Biological Research and Disease Studies
- Hepatitis C virus research
Kyushu University
2013-2016
Summary Hepatocellular carcinoma ( HCC ) is a common cancer worldwide and represents the outcome of natural history chronic liver disease. The growing rates may be partially attributable to increased numbers people with non‐alcoholic fatty disease NAFLD steatohepatitis NASH ). However, details liver‐specific molecular mechanisms responsible for – progression remain unclear, mouse models that can used explore exact factors influence / more stages subsequent are not yet fully established. We...
Abstract A delay in liver regeneration after partial hepatectomy (PHx) leads to acute injury, and such delays are frequently observed aged patients. BubR1 (budding uninhibited by benzimidazole-related 1) controls chromosome mitotic segregation through the spindle assembly checkpoint, down-regulation promotes aging-associated phenotypes. In this study we investigated effects of insufficiency on mice. Low -BubR1 -expressing mutant ( L/L ) mice had a delayed recovery weight-to-body weight ratio...
Abstract DNA aneuploidy is observed in various human tumors and associated with the abnormal expression of spindle assembly checkpoint ( SAC ) proteins. Oxidative stress OS causes damage chromosome instability that may lead to carcinogenesis. also suggested contribute an increase aneuploid cells. However, it not clear how involved regulation contributes carcinogenesis aneuploidy. Here we show oxidant KB rO 3 activated p53 signaling pathway suppressed factors, BubR1, Mad2, diploid fibroblast...
Aim Single nucleotide polymorphisms ( SNP ) around IL‐28B and interferon IFN )‐stimulated gene ISG expression are predictors of response to standard therapy involving for chronic hepatitis C virus HCV infection. We analyzed the association between these improve prediction after liver resection hepatocellular carcinoma HCC ). Methods Data were collected from 74 patients with ‐induced . The genotype hepatic m RNA levels clarify their association, focusing on progression fibrosis. Results Fifty...
Budding uninhibited by benzimidazole-related 1 (BUBR1) plays an important role in the spindle assembly checkpoint to prevent chromosome missegregation and aneuploidy during mitosis. We previously generated mutant mice that express BUBR1 at only 20% of normal level (BubR1L/L mice). Here, we examined effect low expression on oxidative stress-induced carcinogenesis mice.We orally administered either a potassium bromate (KBrO3) solution (2 g/l) or tap water BubR1L/L wild-type (BubR1+/+)mice for...