A5089759774- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Cancer-related molecular mechanisms research
- Neuroendocrine Tumor Research Advances
- Esophageal and GI Pathology
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Intraperitoneal and Appendiceal Malignancies
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Lung Cancer Research Studies
- Testicular diseases and treatments
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Cancer-related gene regulation
Peking University
2016-2025
Peking University Cancer Hospital
2016-2025
King University
2019-2023
Ministry of Education of the People's Republic of China
2013-2022
Weifang Maternity and Child Care Hospital
2018
Inner Mongolia Medical University
2018
Ministry of Education
2018
Dalian Medical University
2017
First Affiliated Hospital of Dalian Medical University
2017
Huazhong University of Science and Technology
2014
Tumor-infiltrating myeloid cells (TIMs) are key regulators in tumor progression, but the similarity and distinction of their fundamental properties across different tumors remain elusive. Here, by performing a pan-cancer analysis single from 210 patients 15 human cancer types, we identified distinct features TIMs types. Mast nasopharyngeal were found to be associated with better prognosis exhibited an anti-tumor phenotype high ratio TNF+/VEGFA+ cells. Systematic comparison between cDC1-...
T cells play a central role in cancer immunotherapy, but we lack systematic comparison of the heterogeneity and dynamics tumor-infiltrating across types. We built single-cell RNA-sequencing pan-cancer atlas for 316 donors 21 types revealed distinct cell composition patterns. found multiple state-transition paths exhaustion CD8+ preference those among different tumor Certain populations showed specific correlation with patient properties such as mutation burden, shedding light on possible...
BackgroundOccult peritoneal metastasis (PM) in advanced gastric cancer (AGC) patients is highly possible to be missed on computed tomography (CT) images. Patients with occult PMs are subject late detection or even improper surgical treatment. We therefore aimed develop a radiomic nomogram preoperatively identify AGC patients.Patients and methodsA total of 554 from 4 centers were divided into 1 training, internal validation, 2 external validation cohorts. All patients' PM status was firstly...
The tumor microenvironment (TME) is connected to immunotherapy responses, but it remains unclear how cancer cells and host tissues differentially influence the immune composition within TME. Here, we performed single-cell analyses for autologous samples from liver metastasized colorectal disentangle factors shaping By aligning CD45+ across different tissues, classified exhausted CD8+ T (Texs) activated regulatory as M-type, whose phenotypes were associated with malignancy, while natural...
Abstract Mapping tumor metabolic remodeling and their spatial crosstalk with surrounding non-tumor cells can fundamentally improve our understanding of biology, facilitates the designing advanced therapeutic strategies. Here, we present an integration mass spectrometry imaging-based metabolomics lipidomics microarray-based transcriptomics to hierarchically visualize intratumor heterogeneity cell interactions in same gastric cancer sample. Tumor-associated reprogramming is imaged at...
The programmed cell death-1 receptor/programmed ligand (PD-1/PD-L1) pathway plays a crucial role in tumor evasion from host immunity. This study was designed to evaluate the association between circulating PD-L1 expression and prognosis patients with advanced gastric cancer.Totally 80 cancer 40 health controls Beijing Cancer Hospital were enrolled present study. Circulating tested by enzyme-linked immunosorbent assay (ELISA). associations level of clinicopathological features analyzed...
Neoadjuvant chemotherapy is a common treatment for patients with gastric cancer. Although its benefits have been demonstrated, neoadjuvant underutilized in cancer management, because of the lack biomarkers patient selection and limited understanding resistance mechanisms. Here, we performed whole-genome, whole-exome, RNA sequencing on 84 clinical samples (including matched pre- posttreatment tumors) from 35 whose responses to were rigorously defined. We observed increased microsatellite...
Abstract Background The tumor microenvironment (TME) has been shown to strongly influence treatment outcome for cancer patients in various indications and the overall survival. However, cells forming TME gastric have not extensively characterized. Results We combine bulk single-cell RNA sequencing from tumors matched normal tissue of 24 treatment-naïve GC better understand which cell types transcriptional programs are associated with malignant transformation stomach. Clustering 96,623...
We investigated the superiority of 8th edition tumor-node-metastasis (TNM) system for patients in China with gastric cancer.The survival outcomes 1663 cancer undergoing radical resection were analyzed.In system, homogeneous 5-year rates among different pathological TNM (pTNM) categories belonging to same stage observed. However, 7th differences rate pTNM observed stages IIB (P = 0.010), IIIB 0.004), and IIIC < 0.001). For pT1-3 0.001) pT4a categories, there significant between pN3a pN3b...
Are other HOX genes, in addition to HOXA10, involved endometrial receptivity? The highly expressed HOXA9, HOXA11 and HOXD10 genes also appear be receptivity. Within the family of homeobox transcription factor are leading candidates for regulation embryonic implantation. A crucial role HOXA10 receptivity has been well established. To identify candidate we performed data mining on all 39 human 'Human body index' gene expression database normal tissue. temporal spatial pattern four endometrium...
The objective of this study is to evaluate the efficiency and safety carbon nanoparticles (CNPs) for harvesting lymph nodes (LNs) in cases advanced gastric cancer (AGC). Patients with previously untreated resectable AGC were eligible inclusion study. All patients randomly allocated two subgroups. In experimental group, 1.0 mL CNP was injected into subserosa stomach around tumor before gastrectomy D2 dissection. same procedure performed directly without any coloring material control arm....
This study was designed to evaluate the impact of postoperative major complications on long-term survival following curative gastrectomy. retrospective included 239 patients with gastric cancer undergoing gastrectomy at Beijing Cancer Hospital from February 2012 January 2013. Survival curves were compared between (mC group) and those without (NmC group). Multivariate analysis conducted identify independent prognostic factors. Postoperative complication mortality rates 24.7 0.8%,...
Patient-derived tumor-like cell clusters may be able to prospectively guide personalized therapeutic selection.
Early gastric cancer is defined as a lesion confined to the mucosa or submucosa, regardless of size lymph node metastasis. Treatment methods include endoscopic mucosal resection submucosal dissection, wedge resection, laparoscopically assisted gastrectomy and open gastrectomy. Lymph metastasis strong related with survival recurrence. Therefore, likelihood one most important factors when determining appropriate treatment.We retrospectively analyzed 597 patients who underwent D2 for early...
Abstract Background HIPEC is an emerging procedure to treat peritoneal metastasis of gastric cancer. Data about in locally advanced cancer scarce. The purpose this trial evaluate the safety and toxicity prophylactic with cisplatin for patients Methods From March 2015 November 2016, a prospective, randomized phase II was conducted. After radical gastrectomy, experimental group underwent followed by adjuvant chemotherapy SOX regime. Patients other were treated regime alone. Postoperative...
The trial was designed to evaluate the efficacy of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin for patients locally advanced gastric cancer (LAGC). Between March 2015 and November 2016, a phase II clinical performed. Fifty consecutive LAGC were randomly assigned two groups: experimental group (radical gastrectomy + HIPEC adjuvant chemotherapy) control chemotherapy). Survival rates closely monitored. 5-year overall survival (OS) rate all 80.0%. OS in lower...
The prognosis for ovarian metastasis of gastric cancer is poor. There no currently available treatment this disease. purpose study was to evaluate the efficacy and safety hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery (CRS) in female patients with metachronous metastasis. From January 2000 December 2010, 62 developed undergoing gastrectomy D2 lymphadenectomy. Thirty-two underwent CRS plus HIPEC, 30 alone. median age all 44 years (range 19-71 years). Metastatic...
Schwannomas are tumors arising from the nervous system that also occur infrequently in gastrointestinal tract, most commonly stomach. This report characterizes 29 patients with benign or malignant gastric schwannomas. Surgical data and clinical follow-up information were available for 28 cases a median postoperative duration of 57 months. Clinicopathological immunohistochemical characteristics schwannomas analysed. Four (13.7%) histologically diagnosed schwannoma. All positive S-100 CD56...
Abstract Xenotransplantation of human cancers into immunodeficient mice is a very useful approach for studying tumor biology. However, the occasional occurrence lymphomagenesis in some can spoil model and must be investigated detail. We found that high percentage (32.5%, 26/80) cancer patient-derived xenografts (PDXs) resembled lymphoma NOD/SCID mice. Of 26 xenografts, 23 were human-derived expressing CD45 (hCD45+) proved to B-cell subtype (CD3-/CD20+) they all positive Epstein - Barr virus...