A5054493891- Cancer-related molecular mechanisms research
- Blood Coagulation and Thrombosis Mechanisms
- Gastric Cancer Management and Outcomes
- Ear Surgery and Otitis Media
- Venous Thromboembolism Diagnosis and Management
- RNA modifications and cancer
- Colorectal Cancer Screening and Detection
- Gut microbiota and health
- Gastrointestinal Tumor Research and Treatment
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Salivary Gland Disorders and Functions
- Atrial Fibrillation Management and Outcomes
- Cancer-related gene regulation
- Intraperitoneal and Appendiceal Malignancies
Kunming Medical University
2019-2025
First Affiliated Hospital of Kunming Medical University
2024
BackgroundOccult peritoneal metastasis (PM) in advanced gastric cancer (AGC) patients is highly possible to be missed on computed tomography (CT) images. Patients with occult PMs are subject late detection or even improper surgical treatment. We therefore aimed develop a radiomic nomogram preoperatively identify AGC patients.Patients and methodsA total of 554 from 4 centers were divided into 1 training, internal validation, 2 external validation cohorts. All patients' PM status was firstly...
Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality, underscoring the urgent need for novel biomarkers and therapeutic targets. Through transcriptomic analysis 4456 genes in TCGA-LUAD cohorts, we identified RBMS3 as significantly downregulated tumor suppressor (log2 fold change = -1.82, adjusted P 3.2 × 10⁻5). Clinically, elevated expression was independently associated with improved overall survival (HR 0.766, 95% CI 0.602-0.973, 0.029), validated by Kaplan-Meier...
The early detection of gastric cancer (GC) is critical for reducing its high mortality rates1,2. Gastric xanthoma (GX), a lipid-associated lesion in the mucosa, has been identified as precursor various stomach malignancies3,4 . In this study, we comprehensively explored profiling gut microbiota, lipid metabolism, and amino acid metabolism to identify novel biomarkers GX, with potential implications GC prevention treatment. Employing 16S rRNA sequencing5,6, transcriptomics 7, gene ontology...
Objective:The aim of this study is to explore the role Th1/Th2 cells imbalance in pathogenesis secretory otitis media. Method:Ninety media patients were enrolled observation group. According medical history, they divided into acute and chronic In addition, 90 healthy volunteers during same period selected as control The levels Th1-type cytokines IFN-γ, Th2-type interleukin-4 (IL-4) IFN-γ/IL-4 peripheral blood compared between group Compare with IL-4, well compare middle ear effusion sIFN-γ,...
We aimed to investigate whether there is a correlation between AT and pleural effusion in PE patients.
The aim of this study was to investigate the biomarkers salivary and fecal microbiota in Colorectal cancer (CRC). Initially, scrutinized microbial community composition disparities among groups. Utilizing Lasso analysis, it sifted through operational taxonomic units (OTUs) pinpoint distinctive features. Subsequently, by intersecting feature OTUs across groups, curated a set core-shared devised corresponding network. Concluding with functional enrichment research delved into divergent...
Ulcerative colitis (UC) is characterised notably by an imbalance in intestinal mucosal homeostasis. Although mitochondrial dysfunction has been identified as a potential contributor to this imbalance, it remains incomplete understanding. Consequently, further investigation into the role of mitochondria UC warranted. The study focusing on GSE87466 dataset for differential gene expression analysis. Mitochondria-related genes were sourced from MitoCart3.0 database. Weighted Gene Co-expression...