A5089918880- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- Pelvic floor disorders treatments
- Cancer-related gene regulation
- Colorectal and Anal Carcinomas
- Gastrointestinal motility and disorders
- Diverticular Disease and Complications
- Histone Deacetylase Inhibitors Research
- Minimally Invasive Surgical Techniques
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Inflammasome and immune disorders
- Pancreatic function and diabetes
Second Affiliated Hospital of Zhejiang University
2014-2025
Zhejiang University
2025
Stomatology Hospital
2025
Qingdao Municipal Hospital
2022-2024
Children's Hospital of Chongqing Medical University
2023-2024
Chongqing Medical University
2023-2024
Chongqing Maternal and Child Health Hospital
2023-2024
Qingdao University
2022-2024
Zithulele Hospital
2024
Yunnan University of Finance And Economics
2024
This study characterizes the demographic, epidemiologic, and clinical characteristics of hospitalized infants diagnosed with coronavirus disease 2019 infection between December 8, 2019, February 6, 2020, in China.
Pyroptosis is a newly discovered programmed cell death that associated with tumor progression, prognosis, and treatment response. However, the potential roles of pyroptosis-related genes (PRGs) in microenvironment (TME) remain unclear. We described alterations PRGs 1109 colorectal cancer (CRC) samples from genetic transcriptional fields evaluated their expression patterns four independent datasets. identified two distinct molecular subtypes found multi-layer PRG were correlated patient...
Introduction: Environmental, social, and governance (ESG) considerations have become increasingly important in the financial market serve as concrete manifestations of sustainable development within a sector. Most corporate leaders adopted ESG concerns an strategy to enhance their performance. Therefore, this study investigated whether affects performance, if relationship is moderated by digital transformation. Method: We used A-share listed companies China from 2015 2021 samples test...
Abstract Dysregulated circular RNAs (circRNAs) contribute to tumourigenesis and cancer progression. However, the expression patterns biological functions of circRNAs in colorectal (CRC) remain elusive. Here, RNA sequencing bioinformatics analyses are applied screen for aberrantly expressed circRNAs. The circFBXW4 CRC tissues cell lines is determined by quantitative real‐time PCR. A series vitro vivo function assays implemented assess circFBXW4. regulatory mechanisms linking circFBXW4,...
Abstract Elevated endoplasmic reticulum (ER) stress is frequently observed in cancers, whereas sustained ER may trigger apoptosis. How cancer cells escape from stress-induced apoptosis remain unclear. Here, we found that a pseudogene-derived lncRNA, Golgin A2 pseudogene 10 (GOLGA2P10), was upregulated HCC tissues and significantly elevated hepatoma treated with inducers, such as tunicamycin thapsigargin. Higher GOLGA2P10 level correlated shorter recurrence-free survival of patients. Upon...
Abstract Mimicking efficient biocatalytic cascades using nanozymes has gained enormous attention in catalytic chemistry, but it remains challenging to develop a nanozyme‐based cascade system sequentially perform the desired reactions. Particularly, integration of sequential hydrolysis and oxidation reactions into systems not yet been achieved, despite their significant roles various domains. Herein, self‐cascade Ce‐MOF‐818 nanozyme for is developed. first Ce(IV)‐based heterometallic...
Background: Genetic characteristics remain underutilized for establishing prognostic models colorectal cancer (CRC). We explored the underlying regulatory mechanisms of circular RNAs (circRNAs) that act as competing endogenous (ceRNAs) and constructed a gene-based nomogram to predict overall survival (OS) in patients with CRC. Methods: obtained circRNA expression profiling data from Gene Expression Omnibus (GEO) database. MicroRNA (miRNA) mRNA profiles, associated clinical data, were The...
Background . Resveratrol (RSV), one of the SIRT1 agonists, has ability alleviating severe acute pancreatitis (SAP); however, concrete protective mechanism remains unknown. It is noteworthy that microcirculation disturbance plays a vital role in SAP, and SIRT1/FOX1 axis can regulate microcirculation. Therefore, this study aimed at ascertaining what underlying effect RSV on whether it associated with by regulating axis. Method The model SAP was induced retrograde injection sodium...
Abstract Background HIPEC is an emerging procedure to treat peritoneal metastasis of gastric cancer. Data about in locally advanced cancer scarce. The purpose this trial evaluate the safety and toxicity prophylactic with cisplatin for patients Methods From March 2015 November 2016, a prospective, randomized phase II was conducted. After radical gastrectomy, experimental group underwent followed by adjuvant chemotherapy SOX regime. Patients other were treated regime alone. Postoperative...
Abstract The development of biomimetic cartilage constructs (BCCs) with natural extracellular matrix (ECM) microenvironments and topological cues to accelerate the reconstruction articular (NAC) after injury is challenging due its complex structure, low cellular content, less vascularity. Inspired by concrete rebar a named “biological reinforced concrete” fabricated, collagen fiber orientation transitioning from parallel perpendicular, replicating ECM construct NAC. 3D‐printed ultrafine...
Patients with cancer frequently develop autoantibodies. The identification of tumor autoantigens may have utility in early diagnosis and immunotherapy. In this study, we used serological proteomics analysis (SERPA) to identify proteins that elicit humoral response colorectal (CRC). CRC cell line HCT116 was as a source for 2-DE subsequent Western blot which individual serum from patients analyzed An autoantibody against HSP60 identified by MS detected 13 out 25 1 15 healthy subjects....
Little information is available on genetic and epigenetic changes in duodenal adenocarcinomas. The purpose was to identify possible subsets of adenocarcinomas based microsatellite instability (MSI), DNA methylation, mutations the KRAS BRAF genes, clinicopathologic features, prognosis.Demographics, tumor characteristics, survival were for 99 adenocarcinoma patients. Testing mutations, MSI, MLH1 CpG island methylator phenotype (CIMP) status conducted. A Cox proportional hazard model built...
Multiple morphological abnormalities of sperm flagella is an idiopathic asthenoteratozoospermia characterized by absent, short, coiled, angulation, and irregular-caliber flagella. Genetic variants DNAH1 gene have been identified as a causative factor multiple intracytoplasmic injection available strategy for infertile males with dynein axonemal heavy chain 1 defects to conceive.
Neurofilament heavy polypeptide (NEFH) has recently been identified as a candidate DNA hypermethylated gene within the functional breast cancer hypermethylome. NEFH exists in complex with neurofilament medium (NEFM) and light (NEFL) to form neurofilaments, which are structural components of cytoskeleton mature neurons. Recent studies reported deregulation these proteins several malignancies, suggesting that neurofilaments may have role other cell types well. Using comprehensive approach, we...
N6-methyladenosine (m6A) and 5-methylcytosine (m5C) can modify long non-coding RNAs (lncRNAs), thereby affecting tumorigenesis tumor progression. However, there is a lack of knowledge regarding the potential roles cross-talk m6A- m5C-related lncRNAs in microenvironment (TME) their effect on prognosis.We systematically evaluated expression patterns 1358 colorectal cancer (CRC) samples from four datasets. Consensus clustering was conducted to identify molecular subtypes CRC, clinical...
Abstract STUDY QUESTION Could actin-related protein T1 (ACTRT1) deficiency be a potential pathogenic factor of human male infertility? SUMMARY ANSWER A 110-kb microdeletion the X chromosome, only including ACTRT1 gene, was identified as responsible for infertility in two Chinese males with sperm showing acrosomal ultrastructural defects and fertilization failure. WHAT IS KNOWN ALREADY The proteins (e.g. ACTRT1, ACTRT2, ACTL7A, ACTL9) interact each other to form multimeric complex...
The aim of the present study was to investigate correlation between four serum biomarkers liver fibrosis and function in infants with cholestasis. A total 30 cholestasis 20 healthy were included study. Biochemical assays based on initial rate method colorimetric conducted determine levels markers [such as alanine aminotransferase (ALT), aspartate (AST), bilirubin (TBIL), direct (DBIL), indirect (IBIL), γ‑glutamyl transferase (γ‑GT), cholinesterase (CHE) bile acids (TBA)] measured using...