Background . Resveratrol (RSV), one of the SIRT1 agonists, has ability alleviating severe acute pancreatitis (SAP); however, concrete protective mechanism remains unknown. It is noteworthy that microcirculation disturbance plays a vital role in SAP, and SIRT1/FOX1 axis can regulate microcirculation. Therefore, this study aimed at ascertaining what underlying effect RSV on whether it associated with by regulating axis. Method The model SAP was induced retrograde injection sodium...

The purpose of this study was to investigate the differentiation trajectory gastric cancer (GC) cells and its clinical relevance generate a prognostic risk scoring (RS) signature based on GC differentiation-related genes (GDRGs) predict overall survival (OS). Integrated single-cell RNA sequencing (scRNA-seq) bulk RNA-seq data from samples were used for analysis. cell analysis identified three subsets with distinct states, which I/II involved in metabolic disorders, subset II also associated...

The potential role of pyroptosis in tumor microenvironment (TME) reprogramming and immunotherapy has received increasing attention. As most studies have concentrated on a single TME cell type or regulator (PR), the overall cell-infiltrating characteristics mediated by integrated roles multiple PRs not been comprehensively recognized. This study curated 33 conducted consensus clustering to identify distinct patterns gastric cancer (GC) patients. A single-sample gene set enrichment analysis...

The present study aims to discover the risk factors of multiple metastases and develop a functional nomogram forecast in metastatic colorectal cancer (mCRC) patients.mCRC cases were retrospectively collected from Surveillance, Epidemiology, End Results (SEER) database between 2010 2016. Survival times single metastasis compared using Kaplan-Meier analysis log-rank tests. Risk for determined by univariate multivariate logistic regression analyses, was developed probability mCRC patients. We...

Background: The construction of ferroptosis-related lncRNA prognostic models in malignancies has been an intense area research recently. However, most the studies focused on exact expression lncRNAs and had limited application values. Herein, we aim to establish a novel model for gastric cancer (GC) patients discuss its correlation with immune landscapes treatment responses. Methods: present study retrieved transcriptional data GC from Cancer Genome Atlas (TCGA) database. We identified...

Abstract Gastric adenocarcinoma (GAC) and colon (CAC) are the most common gastrointestinal cancer subtypes, with a high incidence mortality. Numerous studies have shown that its occurrence progression significantly related to abnormal DNA methylation, especially CpG island methylation. However, little is known about application of methylation in GAC CAC. The profiles were accessed from Cancer Genome Atlas database identify promoter methylation-based subtypes signatures for Six...

Abstract Background Although numerous studies demonstrate the role of cancer stem cells in occurrence, recurrence, and distant metastases gastric (GC), little is known about evolving genetic epigenetic changes progenitor cells. The purpose this study was to identify cell subtypes GC examine their clinical relevance. Methods Two publicly available datasets were used subtypes, consensus clustering performed by unsupervised machine learning methods. (CSC) typing-related risk scoring (RS) model...

Research on the heterogeneity of colon cancer (CC) cells is limited. This study aimed to explore CC cell differentiation trajectory and its clinical implication construct a prognostic risk scoring (RS) signature based differentiation-related genes (CDRGs). Cell analysis was conducted GSE148345 dataset, CDRG-based molecular subtypes were identified from GSE39582 dataset. A RS constructed using The Cancer Genome Atlas as training set validation set. Two subsets with distinct states, involving...

Background: This prospective study aimed to explore the correlation between circulating mitochondrial DNA (mtDNA), intestinal barrier function impairment, and postoperative SIRS in patients undergoing gastrointestinal surgery. Methods: Patients were recruited into this after signing an informed consent form. Circulating serum DAO concentrations measured preoperatively on day 1 7 postoperatively. Postoperative vitals, routine tests, biochemical indicators recorded detail. Results: Forty...

Objective: To analyze the mRNA expression level and methylation status of FOXP3 gene in peripheral blood patients with allergic rhinitis(AR) explore roles pathogenesis AR.Method:According to inclusion exclusion criteria,10 AR patients,10 received SIT treatment for over one year,10 healthy controls were recruited this study.Bisulfate sequencing technology(BSP) was used detect different methyation between controls. Real time fluorescence quantitative reverse transcription-polymerase chain...

Abstract Background: Few studies have focused on the underlying relationship between prognosis of tumor mutation burden (TMB) and immune cell infiltration in gastric cancer (GC). This study aims to explore among TMB various components microenvironment (TME). Methods: The transcription profiles somatic data 375 32 normal samples were obtained from TCGA. specific information was summarized visualized with waterfall chart, then number per million bases each GC sample calculated. Immune/stromal...