A5065760392- Advanced Proteomics Techniques and Applications
- Immune cells in cancer
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Radiomics and Machine Learning in Medical Imaging
- Mass Spectrometry Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cancer, Lipids, and Metabolism
- Signaling Pathways in Disease
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
Shandong Academy of Sciences
2023-2025
Qilu University of Technology
2023-2025
Second Affiliated Hospital of Zhejiang University
2024
Nantong University
2020
Abstract Mapping tumor metabolic remodeling and their spatial crosstalk with surrounding non-tumor cells can fundamentally improve our understanding of biology, facilitates the designing advanced therapeutic strategies. Here, we present an integration mass spectrometry imaging-based metabolomics lipidomics microarray-based transcriptomics to hierarchically visualize intratumor heterogeneity cell interactions in same gastric cancer sample. Tumor-associated reprogramming is imaged at...
The multi-omics approach combining MSI-based metabolomics and N -glycomics visualized spatial distributions of metabolites -glycans in heterogeneous colorectal cancer tissues.
The metabolic cross-talk between tumor and immune cells plays key roles in cell function checkpoint blockade therapy. However, the characterization of immunometabolism its spatiotemporal alterations during response a complex microenvironment is challenging. Here, 3D tumor-immune coculture spheroid model was developed to mimic interactions, combined with mass spectrometry imaging-based spatially resolved metabolomics visualize immunometabolic response. inhibition T simulated by coculturing...
Curcumin is widely recognized for its diverse antitumor properties, ranging from breast cancer to many other types of cancers. However, role in the tumor microenvironment remains be elucidated. In this study, we established a 3D spheroids model that can simulate growth environment cells and visualized metabolic alteration caused by curcumin using mass spectrometry imaging technology. Our results showed not only exerts profound impact on proliferation but situ multivariate statistical...
Objective: To study the expression and clinical significance of calcineurin B homologous protein 2 (CHP2) in gastric cancer (GC) its effect on malignant phenotype GC cells. Methods: The CHP2 297 tissue 198 normal samples were detected by immunohistochemistry. relationship between clinicopathologic parameters analyzed. CHP2-overexpression plasmids CHP2-interference transfected into cell lines respectively. Wound healing assay Transwell experiment was used to detect invasion migration ability...