A5061101612- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer therapeutics and mechanisms
- DNA Repair Mechanisms
- Bladder and Urothelial Cancer Treatments
- Nitrogen and Sulfur Effects on Brassica
- DNA and Nucleic Acid Chemistry
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Nanoparticle-Based Drug Delivery
- Non-Destructive Testing Techniques
- Hemodynamic Monitoring and Therapy
- RNA Interference and Gene Delivery
- vaccines and immunoinformatics approaches
- Cancer-related gene regulation
- Anesthesia and Pain Management
- Electromagnetic Fields and Biological Effects
- Network Packet Processing and Optimization
- Cardiac, Anesthesia and Surgical Outcomes
- Genomics, phytochemicals, and oxidative stress
- Advanced Drug Delivery Systems
- Peer-to-Peer Network Technologies
- Energy Efficient Wireless Sensor Networks
- Cancer, Hypoxia, and Metabolism
- Magnetic Field Sensors Techniques
Bengbu Medical College
2025
Harbin Medical University
2023
Sun Yat-sen University
2020-2023
Sun Yat-sen Memorial Hospital
2020-2023
China Astronaut Research and Training Center
2022
State Key Laboratory of Space Medicine Fundamentals and Application
2022
China Three Gorges Corporation (China)
2022
Lehigh University
2005
Abstract Epitranscriptomic RNA modifications constitute a critical gene regulatory component that can affect cancer progression. Among these, the N4-acetylcytidine (ac4C) modification, which is mediated by ac4C writer N-acetyltransferase 10 (NAT10), regulates stabilization of mRNA. Here, we identified modification induced upon cisplatin treatment and correlates with chemoresistance in bladder cancer. Both vitro vivo, NAT10 promoted cells enhancing DNA damage repair (DDR). Mechanistically,...
Abstract Background Lymphatic metastasis has been associated with poor prognosis in bladder cancer patients limited therapeutic options. Emerging evidence shows that heat shock factor 1 (HSF1) drives diversified transcriptome to promote tumor growth and serves as a promising target. However, the roles of HSF1 lymphatic remain largely unknown. Herein, we aimed illustrate clinical mechanisms explore its potential. Methods We screened most relevant gene among overexpressed factors (HSFs)...
Bladder cancer patients with lymph node (LN) metastasis have an extremely poor prognosis and no effective treatment. The alternative splicing of precursor (pre-)mRNA participates in the progression various tumors. However, precise mechanisms factors cancer-related variants LN bladder remain largely unknown. present study identified a factor, non-POU domain-containing octamer-binding protein (NONO), that was significantly downregulated tissues correlated status, tumor stage, prognosis....
The use of a fluid co-load has been shown to enhance hemodynamic stability and diminish the occurrence hypotension after spinal anesthesia when paired with prophylactic norepinephrine. This research aimed identify effective dosages (ED90 ED50) norepinephrine boluses, in conjunction crystalloid co-load, for prevention cesarean delivery patients. Patients were administered co-loads at dosage 10 mL/kg, addition preventive direct following administration. established employing up-and-down...
This paper proposes a displacement sensing method based on magnetic flux measurement. A bridge-structured circuit, formed by permanent magnets and two ferromagnetic cores, is designed discussed. The analyses of the equivalent circuit three-dimensional finite element simulations showed that density changes linearly with reciprocal sum constant displacement. prototype sensor bridge structure developed consists four as excitation, Hall reception, cores connection. Experiments have validated...
<p>Bladder cancer (BCa) is the most common and lethal urological malignancy. Lymphatic metastasis main type of a poor prognostic factor for bladder patients. Although several treatments are approved BCa patients, some patients still resistant to current therapy. The tumor microenvironment (TME), which consists diverse cellular components, crucial mediator progression treatment resistance. However, literature on interactions between TME lacks coherence systematic analysis, while impact...
Immunotherapy has become one of the most promising therapy methods for cancer, but only a small number patients are responsive to it, indicating that more effective biomarkers urgently needed. This study developed pathway analysis method, named PathwayTMB, identify genomic mutation pathways serve as potential predicting clinical outcome immunotherapy. PathwayTMB first calculates patient-specific pathway-based tumor mutational burden (PTMB) reflect cumulative extent mutations each pathway. It...
<p>Supplementary Figures</p>
<p>Supplementary Materials and Methods</p>
<p>Supplementary Figures</p>
<p>Supplementary Materials and Methods</p>
<div>Abstract<p>Epitranscriptomic RNA modifications constitute a critical gene regulatory component that can affect cancer progression. Among these, the N4-acetylcytidine (ac4C) modification, which is mediated by ac4C writer N-acetyltransferase 10 (NAT10), regulates stabilization of mRNA. Here, we identified modification induced upon cisplatin treatment and correlates with chemoresistance in bladder (BCa). Both <i>in vitro</i> vivo</i>, NAT10 promoted BCa cells...
<p>Supplementary Figures</p>
Packet classification by analyzing the traffic header information is an essential task of network processors. To efficiently store, retrieve and update information, key-based data accessing algorithms such as hashing are usually used to improve processing performance. In this paper, we propose hybrid open hash, a composite algorithm that combines addressing hash tables with temporal responsiveness incremental garbage collection. By dynamically switching between novel table construction via...
<p>Supplementary Figures</p>
<p>Supplementary Materials and Methods</p>
<div>Abstract<p>Epitranscriptomic RNA modifications constitute a critical gene regulatory component that can affect cancer progression. Among these, the N4-acetylcytidine (ac4C) modification, which is mediated by ac4C writer N-acetyltransferase 10 (NAT10), regulates stabilization of mRNA. Here, we identified modification induced upon cisplatin treatment and correlates with chemoresistance in bladder (BCa). Both <i>in vitro</i> vivo</i>, NAT10 promoted BCa cells...
<div>Abstract<p>Epitranscriptomic RNA modifications constitute a critical gene regulatory component that can affect cancer progression. Among these, the N4-acetylcytidine (ac4C) modification, which is mediated by ac4C writer N-acetyltransferase 10 (NAT10), regulates stabilization of mRNA. Here, we identified modification induced upon cisplatin treatment and correlates with chemoresistance in bladder cancer. Both <i>in vitro</i> vivo</i>, NAT10 promoted cells...
<p>Supplementary Materials and Methods</p>
<p>Supplementary Materials and Methods</p>
<p>Supplementary Figures</p>