A5000220618- Alkaloids: synthesis and pharmacology
- Asymmetric Synthesis and Catalysis
- Plasma Diagnostics and Applications
- X-ray Diffraction in Crystallography
- Marine Sponges and Natural Products
- Advanced Synthetic Organic Chemistry
- Crystallization and Solubility Studies
- Oxidative Organic Chemistry Reactions
- Plasma Applications and Diagnostics
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Semiconductor materials and devices
- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Chemical synthesis and alkaloids
- 3D Printing in Biomedical Research
- Traditional and Medicinal Uses of Annonaceae
- Poxvirus research and outbreaks
- Advancements in Semiconductor Devices and Circuit Design
- Vacuum and Plasma Arcs
- Innovative Microfluidic and Catalytic Techniques Innovation
- Additive Manufacturing and 3D Printing Technologies
- Advanced materials and composites
- Plant Virus Research Studies
- Membrane Separation and Gas Transport
Sun Yat-sen Memorial Hospital
2025
Sun Yat-sen University
2025
University of Science and Technology Beijing
2024
Nanjing University of Posts and Telecommunications
2024
Beijing Information Science & Technology University
2024
Purdue University West Lafayette
2020-2023
Nanjing Normal University
2023
California Institute of Technology
2013-2022
National Formosa University
2022
Northwestern Polytechnical University
2020
This report details a general and enantioselective means for the synthesis of alkyl-substituted aziridines. protocol offers direct route chiral aziridines from achiral starting materials. Readily accessed allylic hydroxylamine esters undergo copper hydride-catalyzed intramolecular hydroamination with high degree regio- enantiocontrol to afford aziridine products in good excellent yields highly enantioenriched form. The utility derived this method is further demonstrated through...
The RAA-Cas12a-MPXV assay via fluorescence reader and lateral flow strip.
Abstract The concise total syntheses of the bis(pyrroloindolines) (−)‐lansai B and (+)‐ nocardioazines A are reported. key pyrroloindoline building blocks rapidly prepared by enantioselective formal [3+2] cycloaddition reactions. macrocycle (+)‐nocardioazine is constructed an unusual intramolecular diketopiperazine formation.
A naphthalimide–rhodamine B derivative was synthesized as a fluorescence turn-ON chemodosimeter for Sn4+. colour change and marked enhancement of found in the presence Sn4+, Cu2+ Cr3+ due to ring open reaction rhodamine resonance energy transfer process. Addition strong chelating agent ethylenediaminetetraacetic acid disodium salt (EDTA) partly released cation from complex with Sn4+ restored yellow fluorescence. In addition, compound can be used fluorescent probe biological systems may act...
MOMA-341, first disclosed herein, is a novel, potent, and selective clinical stage small molecule inhibitor of the Werner RecQ like helicase (WRN) that acts through an allosteric, ATP-competitive binding mechanism covalent ligation WRN at cysteine 727. Consistent with genetic depletion in MSI-H models, MOMA-341 induces DNA damage, cell death, tumor regressions mismatch-repair deficient (dMMR)/microsatellite instability high (MSI-H) models but has no effect MSS or lines derived from normal...
As photocrosslinkable materials, methacryloyl-modified hydrogels are widely used as bioinks in tissue engineering. Existing printing methods to use these hydrogels, including changing the viscosity of material or mixing them with other components, have been explored, but their application has limited due low quality high cost. In addition, complex operation bulky equipment restricts existing methods. This study presents a lightweight stereolithography-based three-dimensional (3D) bioprinting...
Abstract The current challenge in cancer research is to increase the resolution of driver prediction from gene-level mutation-level, which more closely aligned with goal precision medicine. Improved methods distinguish drivers passengers are urgently needed dig out mutations increasing exome sequencing studies. Here, we developed an ensemble method, AI-Driver (AI-based classifier, https://github.com/hatchetProject/AI-Driver), predict status somatic missense based on 23 pathogenicity...
Tumor hypoxia is linked to tumor progression, metastasis, and therapy resistance. However, the underlying mechanisms behind this linkage are not fully understood. Here we present a novel fluorescent mCherry hypoxia-responsive marker that can be used in real time imaging specifically sensitively identify hypoxic cells vivo at single cell resolution. Tumors derived from triple negative expressing reveal congregate near flowing blood vessels. Using multiphoton microscopy, MDA-MB-231 were...
An enantioselective synthesis of (-)-10-hydroxyacutuminine is reported. Central to our strategy a photochemical [2+2] cycloaddition that forges two the quaternary stereocenters present in acutumine alkaloids. A subsequent retro-aldol/Dieckmann sequence furnishes spirocyclic cyclopentenone. Efforts chlorinate scaffold at C10 under heterolytic or radical deoxychlorination conditions led an unexpected cyclopropane-containing pentacycle.
The first enantioselective total synthesis of the epipolythiodiketopiperazine (ETP) natural product (−)-acetylapoaranotin (3) is reported. concise was enabled by an eight-step a key cyclohexadienol-containing amino ester building block. absolute stereochemistry both blocks used in set through catalytic asymmetric (1,3)-dipolar cycloaddition reactions. formal syntheses (−)-emethallicin E and (−)-haemotocin are also achieved preparation symmetric diketopiperazine.
Natural gas hydrates, crystalline solids whose molecules are so compressed that they denser than a typical fluid hydrocarbon, have extensive applications in the areas of climate change and energy crisis. The hydrate deposit located Shenhu Area on continental slope South China Sea is regarded as most promising target for exploration China. Samples taken at drilling site SH2 indicated high abundance methane reserves clay sediments. In last few decades, with its relatively low cost,...
Abstract The concise total syntheses of the bis(pyrroloindolines) (−)‐lansai B and (+)‐ nocardioazines A are reported. key pyrroloindoline building blocks rapidly prepared by enantioselective formal [3+2] cycloaddition reactions. macrocycle (+)‐nocardioazine is constructed an unusual intramolecular diketopiperazine formation.
In fields such as polarization navigation and imaging, there is a demand for polarizers to simultaneously possess high transmittance extinction ratio. However, most studies focus solely on single metric polarizer design. To address this issue, paper proposed metasurface with transition layer its efficient design method, aiming enhance the polarizers’ ratio performance simultaneously. An all-dielectric TiO2 was designed, tandem neural network constructed by combining forward prediction...
In this study, white organic light-emitting diodes (OLEDs) consisting of red quantum dots (RQD) and green (GQD) were investigated. These are the most exciting new lighting technologies that have grown rapidly in recent years. The OLED development processes used consisted following methods: (a) fabrication a blue single-emitting layer OLED, (b) nanoimprinting into QD photoresists, (c) photoresists as color conversion layers (CCL) excited by OLEDs. To fabricate HATCN/TAPC pair was selected for...
Seven types of activated carbon were used to investigate the effect their structure on separation CO2 from (H2 + CO2) gas mixture by adsorption method at ambient temperature and higher pressures. The results showed that limiting factors for 53.6 mol% H2 46.4 85.1 14.9 different 20 °C about 2 MPa. best result could be achieved when pore diameter ranged 0.77 1.20 nm, median particle size was 2.07 µm 1.41 mixture. specific area more significant than in phase can decreased 2.3 mol%–4.3 with a...
Abstract An enantioselective synthesis of (−)‐10‐hydroxyacutuminine is reported. Central to our strategy a photochemical [2+2] cycloaddition that forges two the quaternary stereocenters present in acutumine alkaloids. A subsequent retro‐aldol/Dieckmann sequence furnishes spirocyclic cyclopentenone. Efforts chlorinate scaffold at C10 under heterolytic or radical deoxychlorination conditions led an unexpected cyclopropane‐containing pentacycle.
The development of 3D printing has recently attracted significant attention on constructing complex three-dimensional physiological microenvironments. However, it is very challenging to provide a bio-ink with cell-harmless and high mold accuracy during extrusion in printing. To overcome this issue, technique improving the shear-thinning performance semi-IPN bio-ink, which universally applicable all alginate/gelatin-based materials, was developed. Semi-IPN prepared by cyclic heating-cooling...