A5100670895- Venous Thromboembolism Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Metabolomics and Mass Spectrometry Studies
- Genetic Associations and Epidemiology
- COVID-19 Clinical Research Studies
- RNA modifications and cancer
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Heart Failure Treatment and Management
- Pregnancy and preeclampsia studies
- Body Composition Measurement Techniques
- Birth, Development, and Health
- Sirtuins and Resveratrol in Medicine
- Cancer-related gene regulation
- Diamond and Carbon-based Materials Research
- Hepatitis C virus research
- Cardiovascular Disease and Adiposity
- Atrial Fibrillation Management and Outcomes
- Nanoplatforms for cancer theranostics
- Airway Management and Intubation Techniques
- RNA Research and Splicing
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Sichuan University
2022-2023
West China Hospital of Sichuan University
2022-2023
Sun Yat-sen University
2011-2023
Sun Yat-sen University Cancer Center
2022-2023
Jianghan University
2017-2022
Shanghai Pulmonary Hospital
2022
Xuzhou Medical College
2022
University of Benin
2022
Guang’anmen Hospital
2022
A COVID-19 outbreak started in Wuhan, China, last December and now has become a global pandemic. The clinical information caring of critically ill patients with needs to be shared timely, especially under the situations that there is still largely ongoing spread many countries.A multicenter prospective observational study investigated all received 19 ICUs 16 hospitals over 24 h between 8 AM February 2h 27, 2020. demographic information, characteristics, vital signs, complications, laboratory...
To characterize the effect of hepatitis C virus (HCV) polymerase intrinsic genetic heterogeneity on inhibitory activity nucleoside and non-nucleoside HCV inhibitors. The sensitivity genotype (GT) 1 NS5B clinical isolates from treatment-naive patients to inhibitors was assessed. diversity at population level, as well that their quasispecies, correlated with observed reduced R1479 NM107 (nucleoside analogues have entered Phase 2 trials prodrugs R1626 NM283, respectively) were similarly active...
Research on molecular mechanisms of carcinogenesis plays an important role in diagnosing and treating gastric cancer. Metabolic profiling may offer the opportunity to understand mechanism help non-invasively identify potential biomarkers for early diagnosis human The aims this study were explore underlying metabolic cancer associated with morbidity. Gas chromatography/mass spectrometry (GC/MS) was used analyze serum metabolites 30 Chinese patients healthy controls. Diagnostic models...
Background: The outbreak of coronavirus disease 2019 (COVID-19) has led to a large and increasing number patients requiring prolonged mechanical ventilation tracheostomy. indication optimal timing tracheostomy in COVID-19 are still unclear, the outcomes about have not been extensively reported. We aimed describe clinical characteristics with confirmed severe acute respiratory syndrome 2 (SARS-CoV-2) pneumonia who underwent elective tracheostomies. Methods: multi-center, retrospective,...
Aims: This study was aimed to apply a Mendelian randomization design explore the causal association between coronavirus disease 2019 (COVID-19) and three cardio-cerebrovascular diseases, including atrial fibrillation, ischemic stroke, coronary artery disease. Methods: Two-sample used determine following: 1) effect of COVID-19 on fibrillation (55,114 case participants vs 482,295 control participants), (34,541 261,984 stroke (34,217 40,611 which were obtained from European Bioinformatics...
Background Diabetes was considered as a risk factor for venous thromboembolism (VTE), but conflicting findings have been reported from observational studies. This study aimed at investigating the causal associations of type 1 and 2 diabetes with VTE, including deep vein thrombosis (DVT) pulmonary embolism (PE). Methods We designed bidirectional two-sample Mendelian randomization (MR) analysis by using summary-level data large genome-wide association studies performed in European individuals....
Tumor occurrence, progression and metastasis depend on the crosstalk between tumor cells stromal extrinsic factors outside microenvironment. Exosomal microRNA (miRNA) not only is involved in communications within microenvironment but also mediates environment However, most reviews have been limited to role of endogenous exosomal miRNA remodeling Hence, we herein review mediating intercellular microenvironment, inducing formation premetastatic niche. To place our vision summarize for first...
Aim: The promising anti-tumor effect of resveratrol (RES) has aroused much interest in recent years, but its clinical application was seriously hindered due to poor solubility water. aim this study improve the water RES by liposome encapsulation technique for effective tumor treatment.Methods: This develops two liposomal formulations solubilize reverse-phase evaporation method with or without poly(ethylene glycol-2000)-grafted distearolyl phosphatidylethanolamine (DSPE-PEG2000). different...
SARS-CoV-2 is the causative agent for global COVID-19 pandemic; however, interaction between virus and host not well characterized. Natural killer cells play a key role in early phase of antiviral response, their primary functions are dependent on signaling through cell immunoglobulin-like receptor (KIR). This study measured association KIR/HLA class I ligand pairings occurrence development COVID-19. DNA blood samples from 257 patients were extracted used to detect KIR HLA-C gene frequencies...
The aim of the present study was to investigate whether resveratrol could reduce nigral iron levels prevent degeneration dopaminergic neurons in substantia nigra (SN) C57BL/6 mice induced by rotenone. Parkinson's disease (PD) is an age-related neurodegenerative disorder; elevated SN participate neuronal death PD. Resveratrol a kind polyphenolic compounds and possess antioxidant, anticancer, anti-inflammatory biological functions. Although many research groups have investigated...
Abstract The aim of our study was to describe the clinical characteristics and outcomes patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia who underwent elective tracheostomies. We investigated all COVID-19 tracheostomies in intensive care units (ICUs) 23 hospitals Hubei Province, China, from January 8, 2020 March 25, 2020. Demographic information, characteristics, treatment, details tracheostomy procedure, successful weaning after tracheostomy,...
As an important place of material exchange, the homeostasis pulmonary circulation environment and function lays essential foundation for normal execution various physiological functions body. Small metabolic molecules in can reflect corresponding state circulation.We enrolled patients with Patent Foramen Ovale obtained blood from arteries veins through heart catheterization. UPLC-MS based untargeted metabolomics was used to compare changes differences plasma between vein artery.The revealed...
The Chinese Honghe Autonomous Prefecture (Honghe) in Yunnan Province is a unique ethnic area because it inhabited by more than ten different minority groups. Geographically, directly shares border with Vietnam. objective of this study was to investigate genetic diversity and distribution the Hepatitis C virus (HCV) Honghe. Ninety nine subjects who were infected HCV or HCV/HIV (Human Immunodeficiency Virus Type 1) recruited into study. genotypes subtypes determined based on sequences...
Colon adenocarcinoma (COAD) is a prevalent malignant tumor that severely threatens human health across the globe. Immunotherapy an essential need for patients with COAD. N7-methylguanosine (m7G) has been associated diseases, and non-coding RNAs (lncRNAs) regulate various tumor-related biological processes. Nonetheless, m7G-related lncRNAs involved in COAD regulation are limited. This study aims to construct clustering features prognostic model of First, The Cancer Genome Atlas (TCGA)...