A5066122274- Hepatitis C virus research
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Hepatitis B Virus Studies
- Connective tissue disorders research
- Drug-Induced Ocular Toxicity
- Liver Disease Diagnosis and Treatment
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Ocular Surface and Contact Lens
- HIV/AIDS drug development and treatment
- interferon and immune responses
- Ocular Diseases and Behçet’s Syndrome
- Inflammatory mediators and NSAID effects
- Cell Adhesion Molecules Research
- Glaucoma and retinal disorders
- Monoclonal and Polyclonal Antibodies Research
- TGF-β signaling in diseases
- Genetic and Kidney Cyst Diseases
- Peroxisome Proliferator-Activated Receptors
- Systemic Lupus Erythematosus Research
- Ocular Infections and Treatments
- Medical Coding and Health Information
- Ubiquitin and proteasome pathways
Kaiser Permanente Baldwin Park Medical Center
2018-2020
Aravind Eye Hospital
2019
National Institute of Diabetes and Digestive and Kidney Diseases
2014-2019
National Institutes of Health
2014-2019
Kaiser Permanente
2018
Los Angeles Medical Center
2018
Doheny Eye Institute
2015-2017
University of California, Los Angeles
2016
The California Eye Institute
2016
Roche (Switzerland)
2008
To characterize the effect of hepatitis C virus (HCV) polymerase intrinsic genetic heterogeneity on inhibitory activity nucleoside and non-nucleoside HCV inhibitors. The sensitivity genotype (GT) 1 NS5B clinical isolates from treatment-naive patients to inhibitors was assessed. diversity at population level, as well that their quasispecies, correlated with observed reduced R1479 NM107 (nucleoside analogues have entered Phase 2 trials prodrugs R1626 NM283, respectively) were similarly active...
Recent functional genomics studies including genome-wide small interfering RNA (siRNA) screens demonstrated that hepatitis C virus (HCV) exploits an extensive network of host factors for productive infection and propagation. How these co-opted functions interact with various steps HCV replication cycle exert pro- or antiviral effects on remains largely undefined. Here we present unbiased systematic strategy to functionally interrogate dependencies uncovered from our previous infectious...
Cellular microRNAs (miRNAs) have been shown to regulate hepatitis C virus (HCV) replication, yet a systematic interrogation of the repertoire miRNAs impacting HCV life cycle is lacking. Here we apply integrative functional genomics strategies elucidate global HCV-miRNA interactions. Through genome-wide miRNA mimic and hairpin inhibitor phenotypic screens, miRNA-mRNA transcriptomics analyses, identify three proviral nine antiviral that interact with HCV. These are functionally linked...
Most patients with diabetes have little or no retinopathy on initial examination. Tracking the long-term outcomes of these may increase our understanding how to best provide follow-up treatment.To assess many minimal require retinal intervention within 2 years evaluation.This retrospective cohort study assessed who underwent screening for diabetic a telemedicine program at Kaiser Permanente Southern California and had fundus photographs.Retinal interventions performed photographs.Patients...
Purpose: To understand demographic and socioeconomic barriers treatment-seeking behaviors of patients with infectious keratitis requiring therapeutic penetrating keratoplasty (TPK) in a developing country. Methods: This prospective non-comparative questionnaire- based study included all presenting to Aravind Eye Hospital, Madurai that eventuated TPK between November 2015 October 2016. A structured questionnaire was administered on post-operative day 3 collect data the details, predisposing...
Hepatitis C virus (HCV) harnesses host dependencies to infect human hepatocytes. We previously identified a pivotal role of IκB kinase α (IKK-α) in regulating cellular lipogenesis and HCV assembly. In this study, we defined characterized NF-κB-inducing (NIK) as an IKK-α upstream serine/threonine IKK-α-mediated proviral effects the mechanism whereby exploits innate pathway its advantage. manipulated NIK expression Huh7.5.1 cells through loss- gain-of-function approaches examined on...
Purpose. To report the identification of first de novo UBIAD1 missense mutation in an individual with Schnyder corneal dystrophy (SCD). Methods. A slit lamp examination was performed on a 47-year-old woman without family history disorders. The proband’s parents, two sisters, and son were also examined genomic DNA from all six individuals collected. exons exon-intron boundaries screened using Sanger sequencing. Identified mutations for 200 control chromosomes. In silico analysis predicted...
The aim of this study was to characterize International Classification Diseases (ICD-9) coding patterns used by ophthalmologists in clinical practice for hydroxychloroquine (HCQ) retinal toxicity.This is a retrospective cohort study.Patients enrolled the Kaiser Permanente Southern California health plan who were dispensed HCQ between 2001 and 2014 included study.Patients' medical records electronically searched following ICD-9 codes that can be retinopathy or maculopathy: toxic maculopathy,...
Purpose: To investigate the role of zinc finger e-box binding homeobox 1 (ZEB1) transcription factor in posterior polymorphous corneal dystrophy 3 by demonstrating its ability to regulate type IV collagen gene via putative E2 box motifs. Methods: Putative motifs were identified silico analysis within promoter region collagen, IV, alpha3 (COL4A3) and alpha4 (COL4A4). test ZEB1 bind each box, electrophoretic mobility shift assays performed incubating ZEB1-enriched nuclear extracts with...
To characterize the visual outcomes and treatment course of patients with exudative age-related macular degeneration (AMD) based on ocular hypotensive use.A matched retrospective cohort study enrolled in Kaiser Permanente Southern California health plan was conducted. Patients taking hypotensives were identified using pharmacy dispensing data to controls compare acuity, number anti-VEGF injections, conversation secondary agents first year treatment. Subgroup analysis performed (0, 1, 2 or 3+...