A5100694381- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Reproductive Biology and Fertility
- Colorectal Cancer Screening and Detection
- Glioma Diagnosis and Treatment
- Renal and related cancers
- Liver Diseases and Immunity
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Cancer Research and Treatments
- CAR-T cell therapy research
- Metastasis and carcinoma case studies
- Renal cell carcinoma treatment
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Inflammatory Biomarkers in Disease Prognosis
Xuzhou Medical College
2014-2025
Tongji University
2022-2025
Tongji Hospital
2023-2025
Jiangsu University
2019-2025
The University of Texas MD Anderson Cancer Center
2025
Xiamen University of Technology
2024
Nanjing General Hospital of Nanjing Military Command
2013-2024
Southern Medical University
2014-2024
Nanfang Hospital
2024
William & Mary
2024
Abstract Background Noncoding RNAs such as circular (circRNAs) are abundant in the human body and influence occurrence development of various diseases. However, biological functions circRNAs colorectal cancer (CRC) largely unknown. Methods RT-qPCR was used to detect expression mRNA CRC cells tissues. Fluorescence situ hybridization (FISH) analyze location circSPARC. Function-based experiments were performed using circSPARC knockdown overexpression cell lines vitro vivo, including CCK8,...
Accumulating studies have revealed that aberrant expression of circular RNAs (circRNAs) is widely involved in the tumorigenesis and progression malignant cancers, including colorectal cancer (CRC). Nevertheless, clinical significance, levels, features, biological function, molecular mechanisms novel circRNAs CRC remain largely unexplored.CRC-related were identified through bioinformatics analysis verified specimens by qRT-PCR situ hybridization (ISH). Then, vitro vivo experiments performed...
The presence of bacteria in tumor results chemotherapeutic drug resistance and weakens the immune response colorectal cancer. To overcome bacterium-induced potentiate antitumor immunity, herein a novel molecule Biotin-Lys(SA-Cip-OH)-Lys(SA-CPT)-Phe-Phe-Nap (Biotin-Cip-CPT-Nap) is rationally designed containing four functional motifs (i.e., biotin motif for targeting, Phe-Phe(-Nap) self-assembly, ciprofloxacin derivative (Cip-OH) antibacterial effect, camptothecin (CPT) chemotherapy). Using...
Abstract Background Long noncoding RNAs (lncRNAs) have emerged as key players in tumorigenesis and tumour progression. However, the biological functions potential mechanisms of lncRNAs colorectal cancer (CRC) are unclear. Methods The novel lncRNA POU6F2-AS1 was identified through bioinformatics analysis, its expression CRC patients verified via qRT–PCR FISH. In vitro vivo experiments, such BODIPY staining, Oil Red O triglyceride (TAG) assays, liquid chromatography mass spectrometry (LC-MS)...
This work aims to explore the roles and mechanisms of long non coding RNA (lncRNA) THOR in regulating stemness gastric cancer cells. RNA-sequencing combined with quantitative real-time PCR (qRT-PCR) indicated that lncRNA level was significantly upregulated tissues compared normal adjacent tissues. Knockdown attenuated stemnness cells, evident by decrease markers expression capacity cells spheroid formation. Further qRT-PCR western blot analysis demonstrated transcriptional factor SOX9...
Gastric cancer (GC) has been regarded as a kind of the most common cancers in gastrointestinal malignant tumors. Circular RNA (circRNA) is newly discovered category non-coding RNAs and plays significant role initiation or development human cancers. Nevertheless, circPIP5K1A GC remains unclear. The relative expression level circular structure were confirmedby RT-qPCR. biological function was evaluated by colony formation, transwell western blot assays. binding capacity between miR-671-5p (or...
Background . Adenosine, derived from the degradation of ATP via ectonucleotidases CD39 and CD73, is a critical immunosuppressive metabolite in hypoxic microenvironment tumor tissue. Adenosine signaling A2aR can inhibit antitumor immune response CD8 + T cells. CD73 high-expressing Tregs play role evasion gastric cancer (GC). The present study investigated underlying mechanism by which suppress responses GC. Materials Methods Fifty-two GC samples were collected, frequency FoxP3 cells density...
Abstract Inactivating mutations of von Hippel–Lindau (VHL) are highly prevalent in clear cell renal carcinoma (ccRCC). Improved understanding the vulnerabilities VHL-deficient ccRCC could lead to improved treatment strategies. The activity DNA dioxygenase ten-eleven translocation (TET)2 is significantly reduced multiple cancers by different mechanisms, but its role progression remains unclear. Here, we report that increased expression TET2, not TET1 and TET3, negatively associated with tumor...
Abstract Background Gastric cancer is one of the most prevalent malignant tumors within digestive system, and ferroptosis playing a crucial role in its progression. Glutathione peroxidase 4 (GPX4), key negative regulator ferroptosis, highly expressed gastric contributes to tumor growth. Targeting regulation GPX4 has emerged as promising approach induce develop effective therapy for cancer. Methods To confirm that OTUD5 deubiquitinase regulates we performed Western blotting, Co‐IP,...
As the second leading cause of cancer worldwide, colorectal (CRC) is associated with a poor prognosis. Although recent studies have explored prognostic markers in patients CRC, whether tissue microbes carry information remains unknown. Here, by assessing 533 CRC patients, we found that Proteobacteria (43.5%), Firmicutes (25.3%), and Actinobacteria (23.0%) dominated microbiota, which was different from gut microbiota. Moreover, two clear clusters were obtained clustering based on across all...
Abstract MAPK pathway inhibitors (MAPKi) are increasingly used in the treatment of advanced colorectal cancer, but often produce short-lived responses patients. Although acquired resistance by de novo mutations tumors have been found to reduce response some patients, additional mechanisms underlying limited durability targeting therapy remain unknown. Here, we denote new contributory tumor biology and provide insight on impact plasticity response. Analysis MAPKi treated patients revealed...
The relationship between statin therapy and tendon injuries, particularly Achilles tendinopathy, which is the body's largest strongest tendon, remains controversial. This study employed Mendelian Randomization (MR) analysis to explore causal link tendinopathy (ATP). Summary statistics were obtained from genome-wide association studies on medication four specific drugs public databases, as well data related two ATP phenotypes, namely tendinitis injury. Furthermore, a two-sample bidirectional...
Macroautophagy/autophagy is the principal mechanism that mediates delivery of various cellular cargoes to lysosomes for degradation and recycling, has been reported play a crucial role in colorectal cancer (CRC) pathogenesis progression. Targeting autophagy may be promising therapeutic strategy CRC. However, specific functions potential mechanisms CRC remain unclear. In present study, we discovered PTK6 (protein tyrosine kinase 6) could activate inhibit apoptosis. physically interacted with...
Abstract Colorectal cancer is the second common cause of death worldwide. Lamin B2 (LMNB2) involved in chromatin remodeling and rupture reorganization nuclear membrane during mitosis, which necessary for eukaryotic cell proliferation. However, role LMNB2 colorectal (CRC) poorly understood. This study explored biological functions progression possible molecular mechanisms. We found that was significantly upregulated primary tissues lines, compared with paired non-cancerous normal epithelium....
Abstract Background Microsatellite instability‐high (MSI‐H) subgroup of gastric cancer (GC) is characterized by a high tumor mutational burden, increased lymphocytic infiltration, and enhanced inflammatory cytokines. GC patients with MSI‐H status have good response to immune checkpoint blockade management. However, heterogeneity within the subtype underlying mechanisms shaping microenvironments remain poorly understood. Methods RNA expression levels clinical parameters were obtained from The...
Abstract Epidermal electronics that can monitor physiological signals such as surface electromyogram (sEMG) attract widespread attentions in personalized healthcare, human–machine interfaces (HMI) and virtual/augmented reality (AR/VR). However, conventional electromyographic electrodes suffer from skin discomfort, susceptibility to motion artifact interference, short service lifetime. Here, an organohydrogel‐based sEMG electrode endows with high conductivity, low modulus long‐term stability...
Anti-mullerian hormone (AMH) is thought to reflect the growth of follicles and ovarian function. However, role AMH in culture medium during vitro maturation (IVM) on oocyte quality subsequent development potential unclear. The objective this study investigate effect recombinant human (rh-AMH) supplemented into IVM quality. Cumulus-oocyte complexes (COCs) were obtained from ICR mice cultured with different concentrations (0-1,000 ng/ml) rh-AMH. Following 16-18 h culture, quantitative PCR...
Gender differences in immune capabilities suggest that sex hormones such as estrogens were involved the regulation of immunocompetence. Numerous studies also plasmacytoid dendritic cells (PDCs) play a pathogenic role SLE. However, it is unclear whether estrogen can modulate function PDCs to influence development In present study, from murine spleens treated with 17beta-estradiol (E2) and CpG respectively or both vitro, then cell viability, costimulatory molecule expression, cytokine...
Type 2 diabetes (T2DM) is a global epidemic and increases mortality due to its vascular complications. Chemerin has been found exert major role in glucose lipid metabolism. The aim of this study was explore the correlation between plasma chemerin levels microangiopathy patients with T2DM. A total 598 T2DM were classified into two groups: without microvascular Anthropometric parameters blood pressure taken. amounts glycosylated hemoglobin, glucose, profiles, creatinine, concentrations...