A5015829728- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Luminescence and Fluorescent Materials
- DNA and Nucleic Acid Chemistry
- Antimicrobial Peptides and Activities
- Polydiacetylene-based materials and applications
- CRISPR and Genetic Engineering
- Photodynamic Therapy Research Studies
- bioluminescence and chemiluminescence research
- Peptidase Inhibition and Analysis
- Chemical Synthesis and Analysis
- Adenosine and Purinergic Signaling
- Extracellular vesicles in disease
- Spectroscopy Techniques in Biomedical and Chemical Research
- Molecular Sensors and Ion Detection
- Photoacoustic and Ultrasonic Imaging
- Photoreceptor and optogenetics research
- Bacteriophages and microbial interactions
- Click Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Optical Imaging and Spectroscopy Techniques
- Apelin-related biomedical research
State Key Laboratory of Digital Medical Engineering
2019-2025
Southeast University
2019-2025
Collaborative Innovation Center of Chemistry for Energy Materials
2015-2020
University of Science and Technology of China
2015-2020
Chinese Academy of Sciences
2019
Hefei University
2017
National Synchrotron Radiation Laboratory
2015
Abstract Photothermal therapy (PTT), which utilizes near‐infrared light‐absorbing agents to ablate tumor, has emerged as a highly promising anticancer strategy and received intensive clinical trials in recent years. Mild‐temperature PTT, circumvents the limitations of conventional PTT (e.g., thermoresistance adverse effects), is emerging shows great potential forthcoming applications. However, mild‐temperature without adjuvant not able completely eradicate tumors because its therapeutic...
Oral squamous cell carcinoma (OSCC) is the most common oral cancer, having high recurrence and metastasis features. In addition to surgery, photodynamic therapy (PDT) considered as another effective approach for OSCC treatment. The water solubility of currently available PDT photosensitizers (PSs) poor, lowering their singlet oxygen (1O2) yield consequent efficiency. Strategies PS assembly have been reported increase 1O2 yield, but it still possible further enhance this work, we utilized...
Metastasis-induced high mortality of cancers urgently demands new approaches to simultaneously inhibit primary tumor metastasis and distant growth. Herein, by rational design a trident molecule Nap-Phe-Phe-Lys(SA-CPT)-Lys(SA-HCQ)-Tyr(H2PO3)-OH (Nap-CPT-HCQ-Yp) with three functional "spears" (i.e., phosphotyrosine motif for enzymatic self-assembly, camptothecin (CPT) chemotherapy, hydroxychloroquine (HCQ) autophagy inhibition) nanobrush-nanoparticle-nanofiber transition property, we propose...
Abstract Mild‐temperature photothermal therapy (PTT) of tumors has been intensively explored and adopted in preclinical/clinical trials recent years. Nevertheless, tumor thermoresistance significantly compromises the therapeutic efficacy mild‐temperature PTT, therefore, extra addition anti‐thermoresistance agent is needed. Herein, by rational design a peptide‐hydroxychloroquine (HCQ) conjugate Cypate‐Phe‐Phe‐Lys(SA‐HCQ)‐Tyr(H 2 PO 3 )‐OH (Cyp‐HCQ‐Yp), “smart” strategy enzyme‐triggered...
Aggregation-induced emission (AIE) enables "Turn-On" imaging generally through single aggregation of the AIE luminogen (AIEgen). Dual aggregrations AIEgen might further enhance intensity and consequent sensitivity. Herein, we rationally designed a near-infrared (NIR) Ac-Trp-Glu-His-Asp-Cys(StBu)-Pra(QMT)-CBT (QMT-CBT) which, upon caspase1 (Cas1) activation, underwent CBT-Cys click reaction to form cyclic dimers QMT-Dimer (the first aggregation) assembled into nanoparticles second...
Abstract Ischemic stroke is a major cause of death and disability worldwide. The poor drug delivery to cerebral ischemic regions remains challenging issue for treatment. Curcumin (Cur) edaravone (EDV) show remarkable therapeutic effects on stroke. However, the short half‐life aqueous solubility limit their application long‐term effective neuroprotection. Cur EDV with well‐studied hydrogelator Nap‐Phe‐Phe‐Tyr‐OH (NapFFY) co‐assembled prepare novel supramolecular peptide hydrogel...
Abstract Staphylococcus aureus ( S. ) is able to hide within host cells escape immune clearance and antibiotic action, causing life‐threatening infections. To boost the therapeutic efficacy of antibiotics, new intracellular delivery approaches are urgently needed. Herein, by rational design an adamantane (Ada)‐containing antibiotic‐peptide precursor Ada‐Gly‐Tyr‐Val‐Ala‐Asp‐Cys(StBu)‐Lys(Ciprofloxacin)‐CBT Cip‐CBT‐Ada ), we propose a strategy tandem guest‐host‐receptor recognitions precisely...
The presence of bacteria in tumor results chemotherapeutic drug resistance and weakens the immune response colorectal cancer. To overcome bacterium-induced potentiate antitumor immunity, herein a novel molecule Biotin-Lys(SA-Cip-OH)-Lys(SA-CPT)-Phe-Phe-Nap (Biotin-Cip-CPT-Nap) is rationally designed containing four functional motifs (i.e., biotin motif for targeting, Phe-Phe(-Nap) self-assembly, ciprofloxacin derivative (Cip-OH) antibacterial effect, camptothecin (CPT) chemotherapy). Using...
Programmable and algorithmic behaviors of DNA molecules allow one to control the structures DNA-assembled materials with nanometer precision construct complex networks digital analog behaviors. Here we developed a way integrating DNA-strand-displacement circuit self-assembly spherical nucleic acids, wherein single strand was used initiate catalyze operation upstream circuits release that subsequently triggers acids in downstream circuits, realizing programmable kinetic acids. Through...
Toehold-mediated strand displacement reaction, the fundamental basis in dynamic DNA nanotechnology, has proven its extraordinary power programming molecular systems. Programmed activation of toehold a substrate is crucial for building sophisticated devices with digital and behaviors. Here we developed detachable circuit by embedding pH-controlled intermolecular triplex between branch migration domain traditional "linear substrate". The reaction rate "on/off" state can be regulated varying...
Emissive excimers, which are formed by planar polycyclic aromatic fluorophores (e.g., coumarin), enable high contrast tumor imaging. However, it is still challenging to "turn on" excimer fluorescence in physiological dilute solutions. The biocompatible CBT-Cys click condensation reaction enables both intra- and intermolecular aggregations of the as-loaded on probe molecules, may promote generation emissive excimers a synergistic manner. As proof-of-concept, we herein design...
Abstract Derived from the D ‐luciferin regeneration pathway in firefly body, click condensation reaction between 2‐cyanobenzothiazole (CBT) and ‐cysteine (Cys) (CBT‐Cys reaction) possesses unique advantages, including superior biocompatibility, high second order rate, metal‐free mild conditions, emerging as a powerful bioorthogonal tool for variety of chemical biological applications. Moreover, owing to its programmable controllability (e.g., pH, reduction, or enzyme), CBT‐Cys is exploited...
Apoptosis, with a hallmark of upregulated protease Caspase-3, has been frequently imaged various probes to reveal the therapeutic efficiencies different drugs. However, activatable molecular programmable self-assembling behaviors that enable enhanced T1-weighted magnetic resonance imaging (MRI) apoptosis remain scarce. Herein, taking advantage CBT-Cys click reaction, we rationally designed Caspase-3-activatable probe Ac-Asp-Glu-Val-Asp-Cys(StBu)-Lys(DOTA(Gd))-CBT (DEVDCS-Gd-CBT) for in vivo....
Abstract Staphylococcus aureus ( S. ) remains a leading cause of bacterial infections. However, eradication infections with common antibiotics is increasingly difficult due to outbreaks drug resistance. Therefore, new antibiotic classes and antibacterial strategies are urgently in demand. Herein, it shown that an adamantane‐peptide conjugate, upon dephosphorylation by alkaline phosphatase (ALP) constitutively expressed on , generates fibrous assemblies situ combat infection. By attaching...
Near-infrared (NIR) aggregation-induced emission luminogens (AIEgens) are excellent probes for tumor imaging, but there still is space to improve their imaging specificity and sensitivity. In this work, a strategy of tandem targeting dual aggregation an AIEgen proposed achieve these two purposes. An AIEgen, β-tBu-Ala-Cys(StBu)-Lys(Biotin)-Pra(QMT)-CBT (
Versatile building blocks are essential for complex and scaled-up DNA circuits. In this study, we propose a conceptually new scalable architecture called "junction substrate" (J-substrate) that is linked by prepurified double-stranded molecules. As proof-of-concept, novel type of substrate has been utilized to build multi-input circuits, offering several advantages over the conventional (referred as "linear substrate", L-substrate). First, J-substrate does not require long strands, thus...
Autophagy plays a crucial role in tumorigenesis and progression, but current approaches to visualize it vivo show limited precision due their single-analyte-responsive mode. Hence, by simultaneously employing dual autophagy enzymes Atg4B cathepsin B trigger the situ formation of luciferin, we herein propose strategy for precise bioluminescence imaging. An Atg4B-responsive peptide Ac-Thr-Phe-Gly-d-Cys (TFGC) B-activatable compound Ac-Lys-Gly-Arg-Arg-CBT (KGRR-CBT) were rationally designed....