A5100783594- MicroRNA in disease regulation
- Adenosine and Purinergic Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Inflammasome and immune disorders
- Antimicrobial Peptides and Activities
- Chemokine receptors and signaling
- Drug Transport and Resistance Mechanisms
- Cardiac Ischemia and Reperfusion
- interferon and immune responses
- Mitochondrial Function and Pathology
- Nutrition, Genetics, and Disease
- Probiotics and Fermented Foods
- Heme Oxygenase-1 and Carbon Monoxide
- Vagus Nerve Stimulation Research
- Aldose Reductase and Taurine
- Retinoids in leukemia and cellular processes
- Gut microbiota and health
- Curcumin's Biomedical Applications
- Infant Health and Development
Jinzhou Medical University
2024
Fourth Affiliated Hospital of China Medical University
2017-2023
China Medical University
2017-2023
Soochow University
2023
Peking University First Hospital
2017
Peking University
2017
Sichuan University
2016
Chongqing University of Education
2014
Second Military Medical University
2013
Abstract Staphylococcus aureus ( S. ) is able to hide within host cells escape immune clearance and antibiotic action, causing life‐threatening infections. To boost the therapeutic efficacy of antibiotics, new intracellular delivery approaches are urgently needed. Herein, by rational design an adamantane (Ada)‐containing antibiotic‐peptide precursor Ada‐Gly‐Tyr‐Val‐Ala‐Asp‐Cys(StBu)‐Lys(Ciprofloxacin)‐CBT Cip‐CBT‐Ada ), we propose a strategy tandem guest‐host‐receptor recognitions precisely...
Ischaemia reperfusion (IR) induces multiple pathophysiological changes. In addition to its classical role in regulating tumourigenesis, the feedback loop formed by p53 and driven target p53-upregulated modulator of apoptosis (PUMA) was recently demonstrated be common node tightly controlling various cellular responses during myocardial IR. However, roles p53-PUMA spinal cord remain unclear. This study aimed elucidate interactions after IR, specifically investigating their regulation caspase...
Background. Neuron survival after ischemia-reperfusion (IR) injury is the primary determinant of motor function prognosis. MicroRNA- (miR-) based gene therapy has gained attention recently. Our previous work explored mechanisms by which miR-137-3p modulates neuronal apoptosis in both vivo and vitro IR models. Methods. IR-induced dysfunction spinal calpain (CAPN) subtype expression subcellular localization were detected within 12 h post IR. Dysregulated miRs, including miR-137-3p, identified...
Lung cancer is a leading cause of cancer-associated mortality and morbidity worldwide. Previous studies have suggested that ATP-binding cassette transporter E1 (ABCE1) acetylation upregulated in the tissues cells lung associated with prognosis patients cancer. The aim present study was to investigate association between Tat interactive protein 60 kDa (Tip60) expression ABCE1 acetylation, effect Tip60 on biological functions A549 carcinoma cells. levels were examined using western blot...
Lung cancer is the most common tumor in China and worldwide. Despite advances diagnosis therapy, it still represents lethal malignancy industrialized countries. The study of regulatory noncoding RNAs has deepened our understanding on molecular clinical level. In this article, showed that miR-135a was aberrantly downregulated non-small cell lung (NSCLC) cells comparison with normal bronchial epithelial cells, expression inhibited proliferation, invasion metastasis NSCLC vitro. Moreover,...
ATP-binding cassette transporter E1 (ABCE1), a unique ABC superfamily member that bears two Fe-S clusters, is essential for metastatic progression in lung cancer. clusters within ABCE1 are crucial ribosome dissociation and translation reinitiation; however, whether these promote tumor proliferation migration unclear.The interaction between β-actin was confirmed using GST pull-down. The adenocarcinoma (LUAD) cell line A549 transduced with lentiviral packaging vectors overexpressing either...
Background: Insect tea is widely used a traditional drink or Chinese medicine in China. This study was conducted with an aim to determine the vitro anticancer effect of cancer cells. Materials and Methods: The effects were evaluated human tongue carcinoma TCA8113 cells using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometry analysis, nuclear staining 4,6-diamidino-2-phenylindole (DAPI), reverse transcription-polymerase chain reaction (RT-PCR) western...
Lung cancer is a malignant disease, and has the highest incidence mortality worldwide. also popular subject in field of research. The molecular mechanisms lung development, invasion metastasis need to be determined prolong survival times improve quality life. Recent studies have demonstrated that ATP-binding cassette sub-family E member 1 (ABCE1) one factors contributes development cancer, but specific mechanism this phenomenon remains unclear. A polymerase chain reaction microarray was used...
Abstract Staphylococcus aureus ( S. ) is able to hide within host cells escape immune clearance and antibiotic action, causing life‐threatening infections. To boost the therapeutic efficacy of antibiotics, new intracellular delivery approaches are urgently needed. Herein, by rational design an adamantane (Ada)‐containing antibiotic‐peptide precursor Ada‐Gly‐Tyr‐Val‐Ala‐Asp‐Cys(StBu)‐Lys(Ciprofloxacin)‐CBT Cip‐CBT‐Ada ), we propose a strategy tandem guest‐host‐receptor recognitions precisely...