A5103069592- Supramolecular Self-Assembly in Materials
- Advanced Sensor and Energy Harvesting Materials
- Chemical Synthesis and Analysis
- Dielectric materials and actuators
- Advanced biosensing and bioanalysis techniques
- Algebraic Geometry and Number Theory
- Genetics, Aging, and Longevity in Model Organisms
- Antimicrobial Peptides and Activities
- Advanced Memory and Neural Computing
- Analytical Chemistry and Sensors
- Plant Molecular Biology Research
- Gas Sensing Nanomaterials and Sensors
- Cellular transport and secretion
- RNA Interference and Gene Delivery
- Plant tissue culture and regeneration
- Peptidase Inhibition and Analysis
- Synthesis and properties of polymers
- Homotopy and Cohomology in Algebraic Topology
- Photosynthetic Processes and Mechanisms
- Conducting polymers and applications
- Neuroscience and Neural Engineering
- Algebraic structures and combinatorial models
- Surface Modification and Superhydrophobicity
- Adenosine and Purinergic Signaling
- Carbon and Quantum Dots Applications
Brandeis University
2023-2025
Case Western Reserve University
2025
University School
2025
Sichuan University
2021-2024
Guangzhou University
2007-2024
Cornell University
2020-2024
Southeast University
2023
State Key Laboratory of Digital Medical Engineering
2023
Zhejiang University
2023
Chengdu University of Information Technology
2023
Flexible artificial nociceptors and pressure sensory alarm system were fabricated using a memristor based on biopolymers extracted from the seaweed.
Abstract It still remains a challenge to synthesize solid‐state carbon dots (CDs) with high emission efficiency; hurdle that has hindered the application of CDs in many fields. In this work, efficient fluorescent have been prepared through one‐step microwave‐assisted heating method. Experimental data show strong green emissions produced from CD powders (CDPs), carrying an unprecedented 75.9% quantum yield due both spatial confinement and defect reduction introduction NaOH. Likewise, CDPs...
ConspectusHigher-order or supramolecular protein assemblies, usually regulated by enzymatic reactions, are ubiquitous and essential for cellular functions. This evolutionary fact has provided a rigorous scientific foundation, as well an inspiring blueprint, exploring assemblies of man-made molecules that responsive to biological cues novel class therapeutics biomedicine. Among the emerging structures, peptide formed enzyme reactions other stimuli, have received most research attention...
Abstract Staphylococcus aureus ( S. ) is able to hide within host cells escape immune clearance and antibiotic action, causing life‐threatening infections. To boost the therapeutic efficacy of antibiotics, new intracellular delivery approaches are urgently needed. Herein, by rational design an adamantane (Ada)‐containing antibiotic‐peptide precursor Ada‐Gly‐Tyr‐Val‐Ala‐Asp‐Cys(StBu)‐Lys(Ciprofloxacin)‐CBT Cip‐CBT‐Ada ), we propose a strategy tandem guest‐host‐receptor recognitions precisely...
Cholesterol-rich membranes play a pivotal role in cancer initiation and progression, necessitating innovative approaches to target these for inhibition. Here we report the first case of unnatural peptide (1) assemblies capable depleting cholesterol inhibiting cells. Peptide 1 self-assembles into micelles is rapidly taken up by cells, especially when combined with an acute cholesterol-depleting agent (MβCD). Click chemistry has confirmed that depletes cell membrane cholesterol. It localizes...
With the high-frequency development of high-speed communication electronic devices, excellently adhesive materials with low dielectric constant and ultralow loss have been highlighted. However, intrinsically strong (e.g., epoxy) numerous polar functional groups disappointingly deteriorate their properties. Herein, a double cross-linked network maleic-anhydride polybutadiene–amino-terminated polyimide oligomers (MAPB-PIO) is synthesized, then novel sandwich-layered film...
Abstract Staphylococcus aureus ( S. ) remains a leading cause of bacterial infections. However, eradication infections with common antibiotics is increasingly difficult due to outbreaks drug resistance. Therefore, new antibiotic classes and antibacterial strategies are urgently in demand. Herein, it shown that an adamantane‐peptide conjugate, upon dephosphorylation by alkaline phosphatase (ALP) constitutively expressed on , generates fibrous assemblies situ combat infection. By attaching...
Cannabis sativa is known for its therapeutic benefit in various diseases including pain relief by targeting cannabinoid receptors. The primary component of cannabis, Δ9-tetrahydrocannabinol (THC), and other agonists engage the orthosteric site CB1, activating both Gi β-arrestin signaling pathways. activation diverse pathways could result on-target side effects cannabis addiction, which may hinder potential. A significant challenge pharmacology design a ligand that can modulate specific CB1....
The Golgi apparatus is a critical organelle responsible for intracellular trafficking and signaling, orchestrating essential processes such as protein lipid sorting
Despite their critical role in context-dependent interactions for protein functions, intrinsically disordered regions (IDRs) are often overlooked designing peptide assemblies. Here, we exploit IDRs to enable heterotypic assemblies of peptides, where "context-dependent" refers assembly behavior driven by with other molecules. By attaching an aromatic segment oppositely charged achieve a nanofiber formation. Although the same-charged peptides cannot self-assemble, form nanofibers. Cryo-EM...
In this paper, we conduct the first systematic investigation of twisted cubics on Gushel-Mukai (GM) fourfolds. We then study double EPW cube, a 6-dimensional hyperk\"ahler manifold associated with general GM fourfold $X$, through Bridgeland moduli space, and show that it is maximal rationally connected (MRC) quotient Hilbert scheme $X$. also prove cube admits covering by Lagrangian subvarieties constructed from schemes threefolds, which provides new example for conjecture O'Grady.
ABSTRACT Type 2 diabetes affects more than 30 million people in the US, and a major complication is kidney disease. During analysis of lipotoxicity diabetic disease, global fatty acid transport protein-2 (FATP2) gene deletion was noted to markedly reduce plasma glucose db/db mice due sustained insulin secretion. To identify mechanism, we observed that islet FATP2 expression restricted α-cells, α-cell functional. Direct evidence FATP2KO-induced α-cell-mediated GLP-1 secretion included...
A fragment‐based approach has proven successful in drug design and protein assemblies, yet its potential for constructing biomaterials from simple organic building blocks remains underexplored, particularly self‐assembly aqueous phases, where water disrupts intermolecular hydrogen bonding. This study introduces the first case of integrating fragments self‐assembling molecules to a small molecule that forms novel hierarchical nanotubes with polymorphism. The molecule's compact incorporates...
Intrinsically disordered regions (IDRs) are ubiquitous in pro-teins, orchestrating complex cellular signaling through high-er-order protein assemblies. However, the properties and functions of intrinsically peptide (IDP) assemblies largely underexplored. This work unveiled a facile strategy for engineering IDP We demonstrate that conjugating structured motif derived from protein's phosphorylation site to self-assembling tripeptide unexpectedly yields self-assembled nanofibers with intrinsic...
Long noncoding RNAs (lncRNAs) are crucial in porcine preimplantation embryonic development, yet their regulatory role during zygote genome activation (ZGA) is poorly understood. We analyzed transcriptome data from fetal fibroblasts (PEF), induced pluripotent stem cells (iPS), and embryos, identifying ZGA-specific lncRNAs like XLOC-040580, further predicted its potentially interacting genes TPRA1 BCL2L1 via co-expression network. XLOC-040580 was knocked down by siRNA microinjection the...
The potential application of Sr8(Si4O12)Cl8:Eu2+ phosphor in wide gamut 3D-PDP and 3D-FED is demonstrated consideration its high emission intensity (∼148% ∼280% commercial BAM) under VUV light low-voltage electron beam excitation, suitable chromaticity coordinates (0.136, 0.298) short decay time (∼0.9 μs).
We propose a weakly supervised approach for salient object detection from multi-modal RGB-D data. Our only relies on labels scribbles, which are much easier to annotate, compared with dense used in conventional fully setting. In contrast existing methods that employ supervision signals the output space, our design regularizes intermediate latent space enhance discrimination between and non-salient objects. further introduce contour branch implicitly constrain semantic boundaries achieve...
Abstract Targeting immunosuppressive metastatic cancer cells is a key challenge in therapy. We recently have shown that rigid‐rod aromatic, pBP−NBD, responds to enzymes and kill osteosarcoma (mOS) castration resistant prostate (CRPC) mimetic bone microenvironment. However, pBP−NBD demonstrated moderate efficacy against CRPC cells. To enhance activity, we incorporated the unnatural amino acid L‐ or D‐4,4′‐biphenylalanine (L‐ D−BiP) into drastically increasing cellular uptake inhibition....
Abstract Polytetrafluoroethylene (PTFE) and its composite films are difficult to bond with other materials due the molecular chain structure of PTFE, which limits application in electronic fields. In this work, surface modification PTFE/SiO 2 realized through polydopamine (PDA) deposition. The chemical morphological results exhibit that PDA is successfully deposited on films. deposition changes polarity wettability Thus, a significant development adhesive performance obtained, peel strength...