A5100424062- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- HVDC Systems and Fault Protection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Single-cell and spatial transcriptomics
- bioluminescence and chemiluminescence research
- Hybrid Renewable Energy Systems
- Head and Neck Cancer Studies
- Genomics and Chromatin Dynamics
- Liver Diseases and Immunity
- Histone Deacetylase Inhibitors Research
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
Guangzhou Medical University
2021-2025
Guangzhou Medical University Cancer Hospital
2025
The First Affiliated Hospital, Sun Yat-sen University
2022-2024
Sun Yat-sen University
2022-2024
Guangxi Medical University
2022-2024
NYU Langone’s Laura and Isaac Perlmutter Cancer Center
2024
Fudan University
2024
New York University
2020-2024
Beijing Biocytogen (China)
2024
Shanxi Medical University
2023
Cancer cells selectively promote the translation of oncogenic transcripts to stimulate cancer progression. Although growing evidence has revealed that tRNA modifications and related genes participate in this process, their roles head neck squamous cell carcinoma (HNSCC) remain largely uncharacterized. Here, we sought investigate function mechanisms transfer RNA (tRNA) N7-methylguanosine (m7 G) modification regulating occurrence development HNSCC.Cell lost-of-function gain-of-function assays,...
Although gankyrin is involved in the tumorigenicity and metastasis of some malignancies, role cholangiocarcinoma (CCA) unclear. In this study we investigated expression human CCA tissues cell lines. The effects on tumor growth were determined both vivo vitro . results showed that was overexpressed Gankyrin associated with histological differentiation, TNM stage, metastasis. multivariate Cox analysis revealed an independent prognostic indicator for overall survival. overexpression promoted...
To successfully metastasize, cancer cells must evade detachment induced cell death, known as anoikis. Unraveling the mechanisms that gastric (GC) circumvent anoikis and achieve peritoneal metastasis especially during unanchored growth, could significantly improve patient outcomes. Our study reveals GC exhibit increased lipid peroxidation, MDA production, death suspension culture, which can be mitigated by intervention with liproxstatin-1 ferrostatin-1. We discovered oleic acid (OA) or...
Despite advancements in treatment options, the overall cure and survival rates for non-small cell lung cancers (NSCLC) remain low. While small-molecule inhibitors of epigenetic regulators have recently emerged as promising cancer therapeutics, their application patients with NSCLC is limited. To exploit novel therapeutic targets NSCLC, we performed pooled epigenome-wide CRISPR knockout screens vitro vivo identified histone chaperone nucleophosmin 1 (Npm1) a potential target. Genetic ablation...
Tumor-educated platelets (TEPs) are a potential method of liquid biopsy for the diagnosis and monitoring cancer. However, mechanism underlying tumor education is not known, transcripts associated with TEPs often tumor-associated transcripts. We demonstrated that direct transfer to circulating an unlikely source TEP signal. used CDSeq, latent Dirichlet allocation algorithm, deconvolute signal in blood samples from patients glioblastoma. substantial proportion platelet transcriptome derived...
N6-methyladenosine (m6A) is an abundant nucleotide modification in mRNA, but there were few studies on its role cancer drug sensitivity and resistance. Anlotinib has been proved to have effective antitumor effects oral squamous cell carcinoma (OSCC) our previous study. Here, we sought investigate the treatment target of anlotinib function mechanisms m6A regulating effect OSCC.Anlotinib a dose-dependent manner, western blotting, qRT-PCR lost-of-function assays used study OSCC. RNA dot blot...
Abstract Recent small RNA (sRNA) high-throughput sequencing studies reveal ribosomal RNAs (rRNAs) as major resources of sRNA. By reanalyzing sRNA datasets from Gene Expression Omnibus (GEO), we identify 28s rRNA 5’ terminal derived (named 28s5-rtsRNA) the most abundant rRNA-derived sRNAs. These 28s5-rtsRNAs show a length dynamics with identical end and different 3’ end. Through exploring human tissues, 28s5-rtsRNA is found to be highly expressed in bladder, macrophage skin. We also...
Background Head and neck squamous cell carcinoma (HNSCC) is among the most lethal prevalent malignant tumors. Glycolysis affects tumor growth, invasion, chemotherapy resistance, microenvironment. Therefore, we aimed at identifying a glycolysis-related prognostic model for HNSCC to analyze its relationship with immune infiltrations. Methods The mRNA clinical data were obtained from Cancer Genome Atlas (TCGA), while genes Molecular Signature Database (MSigDB). Bioinformatics analysis included...
TF IIB-related factor 1 (Brf1) is a key transcription of RNA polymerase III (Pol III) genes. Our early studies have demonstrated that Brf1 and Pol genes are epigenetically modulated by histone H3 phosphorylation. Here, we further investigated the relationship abnormal expression with high level phosphorylated AMPK
Colon adenocarcinoma (COAD) is a prevalent malignant tumor that severely threatens human health across the globe. Immunotherapy an essential need for patients with COAD. N7-methylguanosine (m7G) has been associated diseases, and non-coding RNAs (lncRNAs) regulate various tumor-related biological processes. Nonetheless, m7G-related lncRNAs involved in COAD regulation are limited. This study aims to construct clustering features prognostic model of First, The Cancer Genome Atlas (TCGA)...
<title>Abstract</title> To successfully metastasize, cancer cells must evade detachment induced cell death, known as anoikis. Unraveling the mechanisms that gastric (GC) circumvent anoikis and achieve peritoneal metastasis especially during unanchored growth, could significantly improve patient outcomes. Our study reveals GC exhibit increased lipid peroxidation, MDA production, death suspension culture, which can be mitigated by intervention with liproxstatin-1 ferrostatin-1. We discovered...
Abstract Background Endothelial cells regulate vascular tone to control the blood pressure (BP) by producing both relaxing and contracting factors. Previously, we identified methyltransferase-like 3 (METTL3), a primary N 6 -methyladenosine (m A) methyltransferase, as key player in alleviating endothelial atherogenic progression. However, its involvement BP regulation remains unclear. Methods To evaluate role of METTL3 vivo , mice with EC specific deficiency (EC- Mettl3 KO ) or without Ang II...
Abstract Tumor cells become dependent on the expression of key genes that drive hallmark tumor traits, but these “addictions” also represent potential vulnerabilities for therapeutic intervention. Treating with a small molecule inhibitor transcriptional kinase CDK7 selectively suppresses dependency in multiple cancers. Our previous work showed responses to THZ1 were especially noteworthy T cell leukemias, lung cancers, and triple-negative breast cancers—tumor types where prognoses are...
Abstract Purpose: N6-methyladenosine (m 6 A) is an abundant nucleotide modification in mRNA, but there were few studies of its role the cancer drug sensitivity and resistance. Anlotinib has been proved to have effective antitumor effects oral squamous cell carcinoma (OSCC) our previous study. Here, we sought investigate treatment target anlotinib function mechanisms m A regulating effect OSCC. Methods: a dose-dependent manner, western blotting, qRT-PCR lost-of assays used study RNA dot blot...
Abstract Kidney renal clear cell carcinoma (KIRC) is the most common subtype of Renal (RCC), with a high degree immune infiltration. This study aimed to identify m6A-related biomarkers and downstream effectors in KIRC that may affect tumor immunity provide prognosis KIRC. In this study, mRNA expression profiles corresponding clinical data patients were downloaded from public databases. The multigene signature was constructed using two transcription factors an m6A-associated gene, TCGA cohort...