A5106822952- Cancer-related gene regulation
- RNA modifications and cancer
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Peptidase Inhibition and Analysis
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Protein Kinase Regulation and GTPase Signaling
- Analytical Chemistry and Sensors
- Kruppel-like factors research
- Protease and Inhibitor Mechanisms
- Analytical Chemistry and Chromatography
- Genomics, phytochemicals, and oxidative stress
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Biosensors and Analytical Detection
- Pharmacological Effects and Assays
- Pluripotent Stem Cells Research
- Histone Deacetylase Inhibitors Research
- Microbial Natural Products and Biosynthesis
- Plant tissue culture and regeneration
- Extracellular vesicles in disease
- Endoplasmic Reticulum Stress and Disease
- Human-Automation Interaction and Safety
Stomatology Hospital
2024
University of Electronic Science and Technology of China
2024
Hospital of Stomatology, Sun Yat-sen University
2023
Fudan University
2010-2023
The First Affiliated Hospital, Sun Yat-sen University
2022-2023
Sun Yat-sen University
2022-2023
Zhongshan Hospital
2018-2023
Guangxi University of Chinese Medicine
2023
Shanghai Institute of Hematology
2023
Shanghai Ninth People's Hospital
2022
Cancer cells selectively promote the translation of oncogenic transcripts to stimulate cancer progression. Although growing evidence has revealed that tRNA modifications and related genes participate in this process, their roles head neck squamous cell carcinoma (HNSCC) remain largely uncharacterized. Here, we sought investigate function mechanisms transfer RNA (tRNA) N7-methylguanosine (m7 G) modification regulating occurrence development HNSCC.Cell lost-of-function gain-of-function assays,...
Fibroblasts can be reprogrammed to induced pluripotent stem cells (iPSCs) by application of transcription factors octamer-binding protein 4 (Oct4), SRY-box containing gene 2 (Sox2), Kruppel-like factor (Klf4), and c-Myelocytomatosis oncogene (c-Myc) (OSKM), but the underlying mechanisms remain unclear. Here, we report that exogenous Oct4 Sox2 bind at promoter regions mir-141/200c mir-200a/b/429 cluster, respectively, induce activation miR-200 family during OSKM-induced reprogramming....
PCIF1 can mediate the methylation of N6,2'-O-dimethyladenosine (m6Am) in mRNA. Yet, detailed interplay between and potential cofactors its pathological significance remain elusive. Here, we demonstrated that PCIF1-mediated cap mRNA m6Am modification promoted head neck squamous cell carcinoma progression both vitro vivo. CTBP2 was identified as a cofactor to catalyze deposition on CLIP-Seq data bound similar mRNAs compared with PCIF1. We then used m6Am-Seq method profile site at single-base...
Profilin is a small 12-15-kDa actin-binding protein, which in eukaryotic organisms ubiquitous and necessary for normal cell growth function. Although profilin's interactions with its three known ligands (actin monomers, phosphatidylinositol 4,5-bisphosphate (PIP2), poly-L-proline (PLP)) have been well characterized vitro, precise role cells remains largely unknown. By binding to clusters of PIP2, profilin able inhibit the hydrolysis PIP2 by phospholipase C gamma 1 (PLC 1). This ability...
Abstract Background Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that regulates ERα expression in triple-negative cancer (TNBC). This study aimed to explore the deubiquitination substrates of UCHL1 related endocrine therapeutic responses and mechanisms dysregulation TNBC. Methods Bioinformatics analysis was conducted using online open databases. TNBC representative MDA-MB-468 SUM149 cells were used for vitro in-vivo studies. Co-immunoprecipitation interaction...
Background: Homeobox A10 (HOXA10) has been implicated in the development and progression of various human cancers. However, precise biological functions HOXA10 hepatocellular carcinoma (HCC) have not defined. Methods: In this study, we examined mRNA expression by quantitative real-time PCR (qRT-PCR) as well histone deacetylase (HDAC) protein levels Western blot HOXA10, HDAC1, Cyclin D1, proliferating cell nuclear antigen (PCNA), Survivin p53 acetylation HCC tissues lines. We also assessed...
The Wnt signaling pathway plays a crucial role in human cancer development, and axis inhibition protein 2 (Axin2) is master scaffold involved signaling. Axin2 negatively regulates acts as tumor suppressor protein. present study evaluated the association between single nucleotide polymorphism (SNP) rs2240308 [guanine (G)/adenine (A)] incidence of prostate cancer. In total, 103 patients with 100 cancer-free control males were included this case-control study, genotyped using genomic DNA...
Distinct opioid receptor agonists have been proved to induce differential patterns of ERK activation, but the underlying mechanisms remain unclear. Here, we report that Ser363 in δ-opioid (δOR) determines different abilities δOR DPDPE and TIPP activate by G-protein- or β-arrestin-dependent pathways. Although both activated ERK1/2, they showed temporal, spatial desensitization activation. We show employed G protein as primary mediator cascade an Src-dependent manner, whereas mainly adopted a...
pathological angiogenesis plays an important role in the progression of chronic liver diseases. Asparaginyl endopeptidase (AEP) participates tumor and was recently shown to be associated with fibrosis. This study aimed explore effect AEP on sinusoidal endothelial cell (LSECs) determine underlying mechanism.cultured LSECs were infected lentiviruses order suppress expression (AEP-KD1, AEP-KD2). The proliferation, apoptosis migration subsequently determined by a CCK8 assay, flow cytometry...
As the world's population ages, healthcare costs become heavy burdens worldwide. Portable point-of-care diagnostic devices, such as glucose meters, can significantly reduce associated with patient care. There are many of small biological molecules present in samples which interest applications. In this paper, a simple low-cost impedance detection circuit has been designed to detect different biomolecules DNA, proteins and other metabolites. particular, across an electrode will change due...
Background: The prognosis of breast cancer varies according to the molecular subtype. Transmembrane 4 L six family 1 (TM4SF1) exhibits different expression patterns among subtypes cancer. However, profile TM4SF1 in hormone receptor HR + HER2 - remains unclear. Methods: mRNA levels were examined major subclasses by analyzing Cancer Genome Atlas (TCGA) datasets. In addition, protein and tissue samples determined immunohistochemistry Western blot assay. effect on cell proliferation was...
The development of autonomous vehicles (AVs) is rapidly transforming transportation, promising increased safety, efficiency, and accessibility. This paper presents an endto-end machine learning approach for vehicle control, encompassing perception, decision-making, actuation. Unlike traditional modular approaches, which rely on separately designed components tasks such as object detection, path planning, our method integrates these stages into a unified model. Leveraging deep techniques,...
Objective: To compare the diagnostic value of [18F]AlF-LNC1007, [18F]FDG, and [18F]AlF-NOTA-FAPI-04 PET/CT in breast cancer. Methods: 33 patients with highly suspected or already diagnosed but untreated cancer were enrolled study underwent [18F]AlF-LNC1007 (30 patients), [18F]FDG (22 (8 patients) PET/CT. Quantitative measurements included SUVmax tumor-to-background ratio (TBR) for all lesions background tissues. The Chi-square test was used intergroup efficacy, Wilcoxon TBR. Diagnostic...
Microvesicles derived from mesenchymal stem cells have a diameter of 30-1000 nm and are small membrane vesicles generated by in resting or activated state. Recent studies found that microvesicles secreted can effectively transport biological active substances such as mRNA, microRNA, proteins, play an important role regulating tissue regeneration. Here we give overview formation mechanisms, properties, their roles lung diseases order to provide some novel information highlight the therapy...