A5101846732- Pluripotent Stem Cells Research
- Tribology and Lubrication Engineering
- Gear and Bearing Dynamics Analysis
- Advanced materials and composites
- Advanced ceramic materials synthesis
- Hematopoietic Stem Cell Transplantation
- Metallurgical Processes and Thermodynamics
- Recycling and utilization of industrial and municipal waste in materials production
- Neurogenesis and neuroplasticity mechanisms
- Synthesis and properties of polymers
- Coal and Its By-products
- Tribology and Wear Analysis
- Alzheimer's disease research and treatments
- Hydrogels: synthesis, properties, applications
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Tissue Engineering and Regenerative Medicine
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Advanced Measurement and Metrology Techniques
- MXene and MAX Phase Materials
- Robotic Path Planning Algorithms
- Electrospun Nanofibers in Biomedical Applications
- Thermochemical Biomass Conversion Processes
- Epoxy Resin Curing Processes
Northeast Agricultural University
2025
Tianjin Agricultural University
2025
University of Chinese Academy of Sciences
2015-2024
Institute of Coal Chemistry
2020-2024
Jiangsu University of Science and Technology
2024
Guizhou University
2021-2024
Tianjin Medical University
2024
Columbia University
2024
Shenyang Aerospace University
2024
Columbia University Irving Medical Center
2021-2023
Fibroblasts can be reprogrammed to induced pluripotent stem cells (iPSCs) by application of transcription factors octamer-binding protein 4 (Oct4), SRY-box containing gene 2 (Sox2), Kruppel-like factor (Klf4), and c-Myelocytomatosis oncogene (c-Myc) (OSKM), but the underlying mechanisms remain unclear. Here, we report that exogenous Oct4 Sox2 bind at promoter regions mir-141/200c mir-200a/b/429 cluster, respectively, induce activation miR-200 family during OSKM-induced reprogramming....
Astrocytes, due to the proximity neuronal lineage and capability proliferate, are ideal starting cells regenerate neurons. Human fetal astrocytes have been successfully converted into by small molecules, which offered a broader range of further applications than transcription factor-mediated reprogramming. Here we report that human adult could also be different set molecules. These induced exhibited typical morphologies, expressed markers, displayed electrophysiological properties....
Mitochondria are the critical organelles for energy metabolism and cell survival in eukaryotic cells. Recent studies demonstrated that mitochondria can intercellularly transfer between mammalian In neural cells, astrocytes into neurons a CD38-dependent manner. Here, using co-culture system of lines, primary human pluripotent stem (hPSC)-derived we further revealed dynamically transferred also from neuronal cells astrocytes, to which CD38/cyclic ADP-ribose signaling mitochondrial Rho GTPases...
This work presents a dynamic perspective for comprehending melt flow at the atomic scale and elucidates mechanism by which oxygen bond structures modify viscosity of melt.
The hydrogel prepared by graft copolymerization of starch (ST) and acrylamide (AM) is a commonly used absorbent material; however, due to their irregular network structure limited number hydrophilic groups, starch-based hydrogels have poor water absorption retention. To overcome this, here, we provide new preparation method for hydrogels. Using cerium ammonium nitrate (CAN) as an initiator, the starch–acrylamide–cellulose (CMC)/poly(ethylene glycol) (S-A-M/PEG) superabsorbent was...
Glioblastoma (GBM) is the most common and aggressive malignant tumor in adult brain. Even with current standard therapy including surgical resection followed by postoperative radiotherapy chemotherapy temozolomide (Temo), GBM patients still have a poor median survival. Reprogramming of cells into non-malignant might be promising therapeutic strategy for tumors, GBM. Based on previous studies using small molecules to reprogram astrocytes neuronal cells, here we further identified FTT cocktail...
Oxidative stress-induced mitochondrial dysfunction and cell senescence are considered critical contributors to Alzheimer's disease (AD), oxidant/antioxidant imbalance has been a therapeutic target in AD. SIRT3 is protein regulating metabolic enzyme activity by deacetylation its downregulation associated with AD pathology. In the present study, we showed that newly synthesized rhamnoside derivative PL171 inhibited generation of reactive oxidant species (ROS) induced amyloid-β 42 oligomers (Aβ...
Abstract In order to reveal the friction properties and improve wear resistance of silicon nitride ceramic materials, a calculation model static coefficient is established. The influence law contact surface roughness on under different load speed analyzed. test results verification are carried out by using Friction Wear Testing Machine. Then dry process simulated based UDEC, failure form ceramics, directly proportional roughness, inversely load, speed. There critical value for sub-contact...
Abstract As a new high-end bearing product, full ceramic ball bearings are favoured in variety. However, there have been few studies on the lubrication of bearings. The purpose this study is to reveal relationship between vibration and temperature rise angular contact lubricant viscosity, improve service life In study, effects viscosity silicon nitride under different axial loads rotation speeds were tested. Herein, mathematical model oil suitable for established film thickness, outer ring...
Here, composite based on quartz fibre-reinforced fluoro-polyimide was fabricated using a hot press process, which reported having well thermal and dielectric properties. The polyimide exhibited extremely high glass transition temperature (Tg) up to 471°C, 5% weight loss (T5) about 560°C both in nitrogen air. Also, optimisation of processing parameters investigated. Moreover, the fibre/polyimide possessed excellent high-temperature mechanical properties due Tg. Importantly, performance....
The segmented-pie composite fibers can be separated by high-pressure hydroentanglement to form a high-strength, lightweight microfiber nonwovens. Nowadays, it is an urgent problem develop easily split and reduce the energy consumption of hydroentangled in bicomponent spunbond technology. Herein, molecular dynamics simulations were first performed for polyester polyamide 6. results reveal that surface adsorption between polymers decreases with decrease polymer chain regularity, cohesion...