A5066607319- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- CRISPR and Genetic Engineering
- Adipose Tissue and Metabolism
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Renal Transplantation Outcomes and Treatments
- Cancer, Lipids, and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Epigenetics and DNA Methylation
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Ubiquitin and proteasome pathways
- Cancer Risks and Factors
- Pluripotent Stem Cells Research
- Cytomegalovirus and herpesvirus research
- RNA regulation and disease
- Cancer Genomics and Diagnostics
Columbia University
2020-2025
The University of Texas Southwestern Medical Center
2017
Oberlin College
2016
University of Pittsburgh
2014-2015
Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death senescence often triggered after mitotic exit. To characterize this process, we conducted CRISPR-mediated loss-of-function screens using a cell-based assay in which mitosis consistently by centrosome loss. We identified 53BP1 and USP28 as essential components acting upstream of p53, evoking p21-dependent cycle arrest response not only to loss, also other distinct defects causing prolonged mitosis....
Sodium-coupled SLC12 cation chloride cotransporters play important roles in cell volume and homeostasis, epithelial fluid secretion, renal tubular salt reabsorption. These are phosphorylated activated indirectly by With-No-Lysine (WNK) kinases through their downstream effector kinases, Ste20- SPS1-related proline alanine-rich kinase (SPAK) oxidative stress-responsive 1 (OSR1). Multiple WNK can coexist within a single type, although relative contributions to SPAK/OSR1 activation transport...
Sodium‐coupled SLC12 cation chloride cotransporters play important roles in cell volume and homeostasis, epithelial fluid secretion, renal tubular salt reabsorption. These are phosphorylated activated indirectly by With‐No‐Lysine (WNK) kinases through their downstream effector kinases, SPAK OSR1. Multiple WNKs can coexist within a single type, although relative contributions to SPAK/OSR1 activation transport remain incompletely understood. Here, we outline simple method selectively knock out...