A5021612929- Cancer-related molecular mechanisms research
- Caveolin-1 and cellular processes
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Protease and Inhibitor Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Metabolism, Diabetes, and Cancer
- TGF-β signaling in diseases
- Kruppel-like factors research
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Angiogenesis and VEGF in Cancer
- FOXO transcription factor regulation
- Cancer, Hypoxia, and Metabolism
Fudan University
2014-2024
The First Affiliated Hospital, Sun Yat-sen University
2014-2019
Zhongshan Hospital
2014-2019
Sun Yat-sen University
2014-2019
Esophageal squamous cell carcinoma (ESCC) remains one of the most common malignancies in China and has a high metastasis rate poor prognosis. Cancer-associated fibroblasts (CAFs), prominent component tumor microenvironment, can affect progression metastasis, but underlying mechanism unclear. There are no studies that explore role hydrogen peroxide-inducible clone 5 (HIC-5) ESCC or compare HIC-5 CAFs adjacent noncancerous normal (NFs). In this study, we isolated primary NFs from patients. was...
The prognosis of gastric cancer (GC) remains poor due to local invasion and distal metastasis. GC-related molecular mechanisms underlying metastasis are not well understood. In this study, we investigated the functional role ANO1 in GC progression. We found that is overexpressed tissues correlated with tumor-node-metastasis stage. Knockdown significantly inhibited cell migration vitro, loss resulted inhibition tumor vivo. Mechanistically, SP1 increased transcription, recruited MLL1 promoter...
pathological angiogenesis plays an important role in the progression of chronic liver diseases. Asparaginyl endopeptidase (AEP) participates tumor and was recently shown to be associated with fibrosis. This study aimed explore effect AEP on sinusoidal endothelial cell (LSECs) determine underlying mechanism.cultured LSECs were infected lentiviruses order suppress expression (AEP-KD1, AEP-KD2). The proliferation, apoptosis migration subsequently determined by a CCK8 assay, flow cytometry...
Forkhead box protein 3 (FOXP3) is implicated in tumor progression and prognosis various types of cells. We have recently reported that FOXP3 inhibited proliferation gastric cancer (GC) cells through activating the apoptotic signaling pathway. In this study, we found over-expression GC cell migration, invasion proliferation. Then, label-free quantitative proteomic approach was employed to further investigating down-stream proteins regulated by FOXP3, resulting a total 3,978 quantified,...
Forkhead box protein 3 (FOXP3) is expressed in numerous types of tumor cell and associated with progression prognosis. A previous study reported that FOXP3 inhibited cellular proliferation induced apoptosis gastric cancer (GC) cells by activating the signaling pathway. In present study, label-free quantitative proteomic analysis chromatin immunoprecipitation-polymerase chain reaction (ChIP-PCR) was performed to investigate mechanism which anticancer role mediated proteins it may interact....
Chemotherapy based on 5-fluorouracil (5-Fu) is the first-line treatment for advanced gastric cancer (GC) patients. Importantly, 5-Fu resistance recognized as a major obstacle successful of GC. Circular RNAs (circRNAs) are non-coding involved in pathogenesis However, their role mechanism GC remains largely unknown. The purpose this study was to explore and elucidate biological function molecular circRNAs underlying