A5102833776- Biofuel production and bioconversion
- Cancer-related gene regulation
- Anaerobic Digestion and Biogas Production
- Pancreatic and Hepatic Oncology Research
- Microbial Metabolic Engineering and Bioproduction
- Phagocytosis and Immune Regulation
- RNA Research and Splicing
- Immune cells in cancer
- RNA modifications and cancer
The First Affiliated Hospital, Sun Yat-sen University
2025
Sun Yat-sen University
2023-2025
PCIF1 can mediate the methylation of N6,2'-O-dimethyladenosine (m6Am) in mRNA. Yet, detailed interplay between and potential cofactors its pathological significance remain elusive. Here, we demonstrated that PCIF1-mediated cap mRNA m6Am modification promoted head neck squamous cell carcinoma progression both vitro vivo. CTBP2 was identified as a cofactor to catalyze deposition on CLIP-Seq data bound similar mRNAs compared with PCIF1. We then used m6Am-Seq method profile site at single-base...
Tumor-initiating cells (TICs) play a key role in cancer progression and immune escape. However, how TICs evade elimination remains poorly characterized. Combining single-cell RNA sequencing (scRNA-seq), dual-recombinase-based lineage tracing, other approaches, we identified WNT-activated subpopulation of malignant that act as vivo. We found intensive reciprocal interactions between regulatory tumor-associated macrophages (Reg-TAMs) via GAS6-AXL/MERTK signaling pathways, which facilitated the...