A5058836834- Retinoids in leukemia and cellular processes
- Genomics and Chromatin Dynamics
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Ferrocene Chemistry and Applications
- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Lipid metabolism and biosynthesis
- Bioactive Compounds and Antitumor Agents
- RNA Research and Splicing
- NF-κB Signaling Pathways
Guangzhou Medical University
2020-2024
Xiamen University
2010
Eastern Hepatobiliary Surgery Hospital
2010
Sanford Burnham Prebys Medical Discovery Institute
2010
Second Military Medical University
2010
Experimental and molecular epidemiological studies indicate important roles for adipose tissue or high-fat diet (HFD) in tumor growth metastasis. Gastric cancer (GC) possesses a metastatic predilection the adipocyte-rich peritoneum. However, precise relevance of HFD peritoneal metastasis GC remains unclear. Here, we showed that causes obvious fat accumulation promotes dissemination vivo. Peritoneum-derived adipocytes induces robust lipid droplet (LD) fatty acid oxidation cells through...
Retinoic acid receptors (RAR; alpha, beta, and gamma), members of the nuclear receptor superfamily, mediate pleiotropic effects vitamin A metabolite retinoic (RA) derivatives (retinoids) in normal cancer cells. Abnormal expression function RARs are often involved growth development cancer. However, underlying molecular mechanisms remain largely elusive. Here, we report that levels RARgamma were significantly elevated tumor tissues from a majority human hepatocellular carcinoma (HCC) HCC cell...
Abstract Adipose tissue is the second most important site of estrogen production, where androgens are converted into by aromatase. While gastric cancer patients often develop adipocyte‐rich peritoneal metastasis, underlying mechanism remains unclear. In this study, we identified G‐protein‐coupled receptor (GPER1) as a promoter metastasis. Functional in vitro studies revealed that β‐Estradiol (E2) or GPER1 agonist G1 inhibited anoikis cells. Additionally, genetic overexpression knockout...
TF IIB-related factor 1 (Brf1) is a key transcription of RNA polymerase III (Pol III) genes. Our early studies have demonstrated that Brf1 and Pol genes are epigenetically modulated by histone H3 phosphorylation. Here, we further investigated the relationship abnormal expression with high level phosphorylated AMPK