A5024413045- interferon and immune responses
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Lung Cancer Research Studies
- Orthopedic Surgery and Rehabilitation
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Metal Forming Simulation Techniques
- Lung Cancer Treatments and Mutations
- Microstructure and mechanical properties
- Aluminum Alloys Composites Properties
- Glioma Diagnosis and Treatment
- Aluminum Alloy Microstructure Properties
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Nerve Injury and Rehabilitation
- Monoclonal and Polyclonal Antibodies Research
- Metallurgy and Material Forming
- Spinal Fractures and Fixation Techniques
- earthquake and tectonic studies
- Spine and Intervertebral Disc Pathology
- Catalysis and Hydrodesulfurization Studies
- Shoulder Injury and Treatment
- Immunotherapy and Immune Responses
- Peripheral Nerve Disorders
Sakurabashi Watanabe Hospital
2001-2025
Icahn School of Medicine at Mount Sinai
2016-2025
Dana-Farber Cancer Institute
2009-2023
Kyushu University
1994-2023
Broad Institute
2011-2023
Tisch Hospital
2022
Tisch Cancer Institute
2022
Pediatrics and Genetics
2022
Center for Information Technology
2022
Cancer Institute (WIA)
2022
Evidence indicates a complex link between gut microbiome, immunity, and intestinal tumorigenesis. To target the microbiota immunity for colorectal cancer prevention therapy, better understanding of relationship microorganisms immune cells in tumor microenvironment is needed. Experimental evidence suggests that Fusobacterium nucleatum may promote colonic neoplasia development by downregulating antitumor T cell-mediated adaptive immunity.To test hypothesis greater amount F carcinoma tissue...
Abstract KRAS-driven lung cancers frequently inactivate TP53 and/or STK11/LKB1, defining tumor subclasses with emerging clinical relevance. Specifically, KRAS-LKB1 (KL)–mutant are particularly aggressive, lack PD-L1, and respond poorly to immune checkpoint blockade (ICB). The mechanistic basis for this impaired immunogenicity, despite the overall high mutational load of KRAS-mutant cancers, remains obscure. Here, we report that LKB1 loss results in marked silencing stimulator interferon...
Abstract Gas‐phase hydrogenation of furfural to tetrahydrofurfuryl alcohol is catalyzed by Ni/SiO 2 with <4 nm Ni particle size, which prepared the reduction supported nickel nitrate. The maximum yield 94 %. conversion furfuryl intermediate less structure‐sensitive. subsequent step in converted inhibited presence because more strongly adsorbed onto catalyst surface than alcohol. This structure‐sensitive and smaller turnover frequency (TOF) values are observed over catalysts a larger size.
Abstract Small cell lung carcinoma (SCLC) is highly mutated, yet durable response to immune checkpoint blockade (ICB) rare. SCLC also exhibits cellular plasticity, which could influence its immunobiology. Here we discover that a distinct subset of uniquely upregulates MHC I, enriching for ICB benefit. In vitro modeling confirms epigenetic recovery I in following loss neuroendocrine differentiation, tracks with derepression STING. Transient EZH2 inhibition expands these nonneuroendocrine...
We have developed a noninvasive pneumatics-based system by which to measure heartbeat, respiration, snoring, and body movements of subject in bed. A thin, air-sealed cushion is placed under the bed mattress small attributable human automatic vital functions are measured as changes pressure using sensor having an almost flat frequency response from 0.1 5 kHz sensitivity 56 mV/Pa. Using newly system, apnea, snoring clearly measured. In addition, optimal signal-to-noise (S/N) ratio evaluate...
The transcription factor SOX2 is an essential regulator of pluripotent stem cells and promotes development maintenance squamous epithelia. We previously reported that oncogene subject to highly recurrent genomic amplification in cell carcinomas (SCCs). Here, we have further characterized the function SCC. Using ChIP-seq analysis, compared SOX2-regulated gene profiles multiple SCC lines ES determined binds distinct loci SCCs. In SCCs, preferentially interacts with p63, as opposed OCT4, which...
Aberrations in epigenetic processes, such as histone methylation, can cause cancer. Retinoblastoma binding protein 2 (RBP2; also called JARID1A or KDM5A) demethylate tri- and dimethylated lysine 4 H3, which are marks for transcriptionally active chromatin, whereas the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor promotes H3K4 methylation. Previous studies suggested that inhibition of RBP2 contributed to suppression by retinoblastoma (pRB). Here, we show genetic ablation Rbp2...
Alterations in the processing of genetic information carcinogenesis result from stable mutations or epigenetic modifications. It is becoming clear that nucleosomal histones are central to proper gene expression and aberrant DNA methylation genes histone plays important roles tumor progression. To date, several lysine methyltransferases (HKMTs) have been identified now considered be a critical regulator transcription. However, still relatively little known about role HKMTs tumorigenesis.We...
Abstract The hydrogenolysis of erythritol using an Ir–ReO x /SiO 2 catalyst was performed for the production butanediols, which are widely used as a raw material polymers. activity and selectivity to butanediols on much higher than that conventional catalysts. maximum 1,4‐ 1,3‐butanediols reached 33 12 % at 74 conversion, respectively. conversion almost maintained during four repeating tests if small amounts acid were added reaction calcined again. kinetics, reactivity trends,...
The structural change of Ir/SiO2 and Ir–ReOx/SiO2 during the temperature programmed reduction with H2 was investigated using in situ Ir L3-edge Re quick-scanning X-ray absorption fine structure combination H2, XRD, measurement CO adsorption, Raman spectroscopy, photoelectron spectroscopy. metal oxide on much more easily reduced than that monometallic ReOx/SiO2, which is explained by interaction between trioxo species IrO2 phase. constructed after at 485–595 K cuboctahedron particles covered...
Abstract As a master regulator of chromatin function, the lysine methyltransferase EZH2 orchestrates transcriptional silencing developmental gene networks. Overexpression is commonly observed in human epithelial cancers, such as non–small cell lung carcinoma (NSCLC), yet definitive demonstration malignant transformation by deregulated remains elusive. Here, we demonstrate causal role overexpression NSCLC with new genetically engineered mouse models adenocarcinoma. Deregulated silences normal...
Abstract Acquired drug resistance is a major factor limiting the effectiveness of targeted cancer therapies. Targeting tumors with kinase inhibitors induces complex adaptive programs that promote persistence fraction original cell population, facilitating eventual outgrowth inhibitor-resistant tumor clones. We show addition newly identified CDK7/12 inhibitor, THZ1, to therapy enhances killing and impedes emergence drug-resistant populations in diverse cellular vivo models. propose state...
Abstract Adenosquamous lung tumours, which are extremely poor prognosis, may result from cellular plasticity. Here, we demonstrate lineage switching of KRAS+ adenocarcinomas (ADC) to squamous cell carcinoma (SCC) through deletion Lkb1 (Stk11) in autochthonous and transplant models. Chromatin analysis reveals loss H3K27me3 gain H3K27ac H3K4me3 at genes, including Sox2, ΔNp63 Ngfr . SCC lesions have higher levels the H3K27 methyltransferase EZH2 than ADC lesions, but there is a clear lack...
Abstract Modification of Ru/C with a small amount MoO x (RuMoO /C) enhanced the catalytic activity in hydrogenation L ‐lactic acid to form 1,2‐propanediol and maintained high selectivity. The turnover frequency based on Ru over optimized RuMoO /C catalyst (Mo/Ru molar ratio=1:16) was 114 h −1 at 393 K, which about 4 times higher than that Ru/C. same effect obtained /SiO 2 , although showed slightly lower /C. achieved yield 95 % 18 K applicable various carboxylic acids provide corresponding...