A5024424422- Microstructure and Mechanical Properties of Steels
- Aluminum Alloys Composites Properties
- Metallurgy and Material Forming
- High Temperature Alloys and Creep
- Advanced ceramic materials synthesis
- Hydrogen embrittlement and corrosion behaviors in metals
- Aluminum Alloy Microstructure Properties
- Immunotherapy and Immune Responses
- Metal Alloys Wear and Properties
- Advanced materials and composites
- Thermal properties of materials
- Nuclear Materials and Properties
- Corrosion Behavior and Inhibition
- Magnesium Alloys: Properties and Applications
- Microstructure and mechanical properties
- Monoclonal and Polyclonal Antibodies Research
- Electronic Packaging and Soldering Technologies
- Fatigue and fracture mechanics
- Cancer Immunotherapy and Biomarkers
- Mechanisms of cancer metastasis
- Fusion materials and technologies
- Metal and Thin Film Mechanics
- Intermetallics and Advanced Alloy Properties
- RNA modifications and cancer
- 3D IC and TSV technologies
Hunan Normal University
2022-2025
Hunan Provincial People's Hospital
2022-2025
Xuzhou Central Hospital
2019-2025
Xuzhou Medical College
2025
University of Science and Technology Beijing
2015-2024
Key Laboratory for High Strength Lightweight Metallic Materials of Shandong Province
2019-2024
Qilu University of Technology
2019-2024
Guangzhou Electronic Technology (China)
2024
First Affiliated Hospital of Zhengzhou University
2024
Shandong Academy of Sciences
2019-2024
The programmed death-1 (PD-1) receptor serves as an immunologic checkpoint, limiting bystander tissue damage and preventing the development of autoimmunity during inflammatory responses. PD-1 is expressed by activated T cells downmodulates T-cell effector functions upon binding to its ligands, PD-L1 PD-L2, on antigen-presenting cells. In patients with cancer, expression tumor-infiltrating lymphocytes interaction ligands tumor immune in microenvironment undermine antitumor immunity support...
The programmed death protein (PD-1) and its ligand (PD-L1) play critical roles in a checkpoint pathway cancer cells exploit to evade the immune system. A same-day PET imaging agent for measuring PD-L1 status primary metastatic lesions could be important optimizing drug therapy. Herein, we have evaluated tumor targeting of an anti–PD-L1 adnectin after <sup>18</sup>F-fluorine labeling. <b>Methods:</b> An was labeled with <sup>18</sup>F 2 steps. This synthesis featured fluorination novel...
Abstract Small cell lung carcinoma (SCLC) is highly mutated, yet durable response to immune checkpoint blockade (ICB) rare. SCLC also exhibits cellular plasticity, which could influence its immunobiology. Here we discover that a distinct subset of uniquely upregulates MHC I, enriching for ICB benefit. In vitro modeling confirms epigenetic recovery I in following loss neuroendocrine differentiation, tracks with derepression STING. Transient EZH2 inhibition expands these nonneuroendocrine...
Multidrug-resistant Klebsiella pneumoniae (MRKP) has steadily grown beyond antibiotic control. However, a bacteriophage is considered to be potential alternative for treating bacterial infections. In this study, lytic bacteriophage, phage 1513, was isolated using clinical MRKP isolate KP 1513 as the host and characterized. It produced clear plaque with halo classified Siphoviridae. had short latent period of 30 min, burst size 264 could inhibit growth in vitro dose-dependent pattern....
Zirconium alloys are widely used in nuclear reactors as structural materials. During the operation, they exposed to fast neutrons. Ion irradiation is simulate damage introduced by neutron irradiation. In this article, we briefly review of zirconium alloys, then summarize effect ion on microstructural evolution, mechanical and corrosion properties, their relationships. The microstructure components consist dislocation loops, second phase precipitates, gas bubbles. parameters also included...
Hot deformation behaviors and dynamic softening mechanisms of the 7Mo super-austenitic stainless steel (SASS) were studied in temperature range 1000–1200 °C stain rate 0.001–10 s−1. It is found optimum windows hot are mainly 1030–1200 strain 0.001–0.07 s−1, 1050–1200 10 The apparent activation energy SASS has reached 558.9 kJ mol−1, which about 100–180 mol−1 larger than ordinary austenitic steels 60–95 4.5–6 wt.% Mo steels. Due to high stacking fault (SFE, 161.2 mJ m−2), planar gliding...
Abstract Pattern recognition receptors are preferentially expressed on APCs allowing selective uptake of pathogens for the initiation antimicrobial immunity. In particular, C-type lectin receptors, including mannose receptor (MR), facilitate APC-mediated adsorptive endocytosis microbial glyconjugates. We have investigated potential antigenic targeting to MR as a means induce Ag-specific humoral and cellular hMR transgenic (hMR Tg) mice were generated allow specific with anti-hMR Ab, B11....