A5075989964- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Cancer Immunotherapy and Biomarkers
- Advanced MRI Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Radiation Dose and Imaging
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- CAR-T cell therapy research
- bioluminescence and chemiluminescence research
- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Fibroblast Growth Factor Research
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Assisted Reproductive Technology and Twin Pregnancy
- Neuroscience and Neuropharmacology Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- MRI in cancer diagnosis
- Sphingolipid Metabolism and Signaling
- Chronic Myeloid Leukemia Treatments
- PI3K/AKT/mTOR signaling in cancer
- Treatment of Major Depression
- Neuroblastoma Research and Treatments
- Growth Hormone and Insulin-like Growth Factors
Bristol-Myers Squibb (United States)
2008-2023
Bristol-Myers Squibb (Belgium)
2023
University of California, Los Angeles
2003-2006
Institute for Molecular Medicine
2004-2005
Chinese University of Hong Kong
2005
The programmed death protein (PD-1) and its ligand (PD-L1) play critical roles in a checkpoint pathway cancer cells exploit to evade the immune system. A same-day PET imaging agent for measuring PD-L1 status primary metastatic lesions could be important optimizing drug therapy. Herein, we have evaluated tumor targeting of an anti–PD-L1 adnectin after <sup>18</sup>F-fluorine labeling. <b>Methods:</b> An was labeled with <sup>18</sup>F 2 steps. This synthesis featured fluorination novel...
Attenuation correction is one of the important corrections required for quantitative positron emission tomography (PET). This work will compare accuracy attenuation using a simple global scale factor with traditional transmission-based methods acquired either small animal PET or x-ray computed (CT) scanner. Two phantoms (one mouse-sized and rat-sized) two subjects mouse rat) were scanned in CTI Concorde Microsystem's microPET Focus transmission data ImTek's MicroCAT II data. image values...
The purpose of this work was to calculate radiation dose and its organ distribution in a realistic mouse phantom from micro‐computed tomography (microCT) imaging protocols. CT calculated using GATE voxelized, phantom. x‐ray photon energy spectra used simulations were precalculated with validated against previously published data. number photons required per simulated experiments determined by direct exposure measurements. Simulated performed for three types beams two beds. Dose‐volume...
Many research institutions have a full suite of preclinical tomographic scanners to answer biomedical questions in vivo. Routine multi-modality imaging requires robust registration images generated by various tomographs. We implemented hardware method for that is similar used the combined positron emission tomography (PET)/computed (CT) clinic. designed an chamber which can be rigidly and reproducibly mounted on separate microPET microCT scanners. also three-dimensional grid phantom with...
Hydrosalpinx (HSP) has been shown to be detrimental the outcome of assisted reproduction, but little is known its pathology. This prospective study examined and detailed ultrastructural characterization HSP infertile women presenting for reproductive treatments. Both light electron microscopies were used characterize HSP. Hematoxylin eosin staining showed areas without epithelial cell lining or with abnormalities such as flattening layer exfoliation cells occasional normal columnar lining....
Major depressive disorder is a leading cause of disability globally. Improvements in the efficacy antidepressant therapy are needed as high proportion (>40%) individuals with major fail to respond adequately current treatments. The non-selective N-methyl-D-aspartate receptor channel blocker, (±)-ketamine, has been reported produce rapid and long-lasting response treatment-resistant patients, which provides unique opportunity for investigation mechanisms that mediate its therapeutic effect....
Background Treatments for nonalcoholic steatohepatitis (NASH) are urgently needed. Hepatic fat fraction and shear stiffness quantified by magnetic resonance imaging (MRI‐HFF) elastography (MRE‐SS), respectively, biomarkers hepatic steatosis fibrosis. Purpose This study assessed the longitudinal effects of fibroblast growth factor 21 variant (polyethylene glycol [PEG]‐FGF21v) on MRI‐HFF MRE‐SS in a NASH mouse model. Study Type Preclinical. Animal Model included choline‐deficient, amino...
In cancer immunotherapy, the blockade of interaction between programmed death-1 and its ligand (PD-1:PD-L1) has proven to be one most promising strategies. However, as mechanisms resistance PD-1/PD-L1 inhibition include variability in tumor cell PD-L1 expression addition standard biopsy immunohistochemistry (IHC), a comprehensive quantitative approach for measuring is required. Herein, we report development characterization an
Biological research in recent years has generated significant interest for vivo small animal imaging technologies. 3D X-ray computed tomography (CT) provides anatomical images with high spatial resolution and good bone-to-soft tissue contrast. Radiation doses to the subject can be when soft contrast high-resolution are desired. We have used MCNP Monte Carlo simulation, calibrated thermoluminescent dosimeters (TLD's), combination spectra obtained a cadmium zinc telluride (CZT) detector,...
Imaging with Positron Emission Tomography (PET) requires compensation for attenuation of the annihilation photons in subject tissues. Although magnitude this correction small subjects is significantly smaller than humans, it Is important a quantitatively accurate representation tracer distribution. Attenuation (AC) has been implemented on Concorde microPET/spl reg/ P4 scanner using Ge-68 point source (PS) that spirals through field view under computer control. Transmission (TX) scans...
<title>Abstract</title> <bold>Purpose:</bold>In cancer immunotherapy, the blockade of interaction between programmed death-1 and its ligand (PD-1:PD-L1) has proven to be one most promising strategies. However, as mechanisms resistance PD-1/PD-L1 inhibition include variability in tumor cell PD-L1 expression addition standard biopsy immunohistochemistry (IHC), a comprehensive quantitative approach for measuring is required. Herein, we report development characterization...
Small animal anatomical imaging with x-ray computed tomography (CT) in cone-beam geometry suffers from inaccuracies the measured attenuation coefficient due to acceptance of scattered radiation. This work seeks estimate magnitude and effect scatter a commercial microCT scanner both projections reconstructed images. The scatter-to-primary ratio (SPR) is estimated using beam stop method simulation. We also make initial attempts quantitate amount inaccuracy image values under different...
e14501 Background: The type 1 insulin-like growth factor receptor (IGF-1R) plays a critical role in mitogenesis and survival variety of human tumor cells. IGF-1R is also closely related to the insulin (IR). It becoming increasingly evident that stimulation IR or IR/IGF-1R hybrid receptors by IGF-1/2 may contribute cancer growth, suggesting both be targets for therapy. BMS-754807 (‘807) an oral tyrosine kinase antagonist under development blocks activity. This study explores feasibility...
<b>Rationale and Aim:</b> Studies linking the lysophosphatidic acid 1 receptor (LPA<sub>1</sub>) to pathogenesis of lung kidney fibrosis have identified LPA<sub>1</sub> as a potential clinical target for idiopathic pulmonary (IPF). antagonism has shown efficacy in Phase 2 IPF trial. Here we report evaluation BMS-986327 PET ligand detect expression assess engagement occupancy LPA1-targeted drugs. <b>Methods:</b> binding was measured competition with antagonists whole-cell assay. imaging...
Abstract Objectives Inhibition of the Programmed Death Ligand-1 (PD-L1)/PD-1 interaction allows for potent anti-tumor activity and antibodies that disrupt this have been approved treatment multiple cancer types. PD-L1 expression has investigated clinically as a potential biomarker to predict response anti-PD-1/PD-L1 therapy. BMS-986192, an Adnectin with high affinity specificity human PD-L1, was selected in vitro from complex library. Here we report discovery first preclinical evaluation...
MAP (maximum a posteriori) reconstructions of transmission images produce more accurate ACFs (attenuation correction factors) than smoothed division blank and scans analytical methods. Also, for highly specific tracers, can provide useful anatomical cues use in localizing structures image coregistration. The resolution reconstructed with spatially invariant smoothing prior is known to be nonuniform. Spatially variant parameters are used achieve uniform throughout the image. We also...