A5059183616- Cancer Immunotherapy and Biomarkers
- Melanoma and MAPK Pathways
- Cutaneous Melanoma Detection and Management
- Radiopharmaceutical Chemistry and Applications
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
- Peptidase Inhibition and Analysis
- Cutaneous lymphoproliferative disorders research
- Chronic Lymphocytic Leukemia Research
- Cellular transport and secretion
- Ubiquitin and proteasome pathways
- Radiomics and Machine Learning in Medical Imaging
- HER2/EGFR in Cancer Research
- Lymphoma Diagnosis and Treatment
- Respiratory viral infections research
- Poxvirus research and outbreaks
- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Clostridium difficile and Clostridium perfringens research
- Blood groups and transfusion
- Nonmelanoma Skin Cancer Studies
- Cervical Cancer and HPV Research
- Antimicrobial Resistance in Staphylococcus
Bristol-Myers Squibb (United States)
2014-2024
Baylor College of Medicine
2016-2023
Michael E. DeBakey VA Medical Center
2016-2023
Critical Path Institute
2022
PathAI (United States)
2022
Duke Medical Center
2021
University of Pennsylvania
2021
National Yang Ming Chiao Tung University
2021
Stony Brook University
2021
Bristol-Myers Squibb (Germany)
2012-2020
The programmed death protein (PD-1) and its ligand (PD-L1) play critical roles in a checkpoint pathway cancer cells exploit to evade the immune system. A same-day PET imaging agent for measuring PD-L1 status primary metastatic lesions could be important optimizing drug therapy. Herein, we have evaluated tumor targeting of an anti–PD-L1 adnectin after <sup>18</sup>F-fluorine labeling. <b>Methods:</b> An was labeled with <sup>18</sup>F 2 steps. This synthesis featured fluorination novel...
Immune checkpoint inhibitors such as ipilimumab and targeted BRAF have dramatically altered the landscape of melanoma therapeutics over past few years. Agents targeting programmed cell death-1/ligand (PD-1/PD-L1) axis are now being developed appear to be highly active clinically with favorable toxicity profiles. We report two patients V600E mutant who were treated anti-PD-1 agents first-line therapy without significant toxicity, followed by vemurafenib at disease progression. Both severe...
SummaryAdnectins are targeted biologics derived from the tenth type III domain of human fibronectin (10Fn3), a member immunoglobulin superfamily. Target-specific binders selected libraries generated by diversifying three 10Fn3 loops that analogous to complementarity determining regions antibodies. The crystal structures two Adnectins were determined, each in complex with its therapeutic target, EGFR or IL-23. Both bind different epitopes than those bound known monoclonal Molecular modeling...
Epitope mapping the specific residues of an antibody/antigen interaction can be used to support mechanistic interpretation, antibody optimization, and epitope novelty assessment. Thus, there is a strong need for methods, particularly integrative ones. Here, we report identification energetic by determining interfacial hot-spot that dominates binding affinity anti-interleukin-23 (anti-IL-23) using complementary approaches hydrogen/deuterium exchange mass spectrometry (HDX-MS), fast...
Assessment of programmed death ligand 1 (PD-L1) expression by immunohistochemistry (IHC) has emerged as an important predictive biomarker across multiple tumor types. However, manual quantitation PD-L1 positivity can be difficult and leads to substantial inter-observer variability. Although the development artificial intelligence (AI) algorithms may mitigate some challenges associated with assessment improve accuracy scoring, use AI-based approaches oncology scoring drug been sparse,...
Abstract Background Intensive studies have failed to identify an etiologic agent in &gt;50% cases of community-acquired pneumonia (CAP). Bacterial follows aspiration recognized bacterial pathogens (RBPs) such as Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus after they colonize the nasopharynx. We hypothesized that normal respiratory flora (NRF) might also cause CAP. Methods studied 120 patients hospitalized for CAP who provided a high-quality sputum specimen...
Blocking the interaction of immune checkpoint molecule programmed cell death protein-1 and its ligand, PD-L1, using specific antibodies has been a major breakthrough for oncology. Whole-body PD-L1 expression PET imaging may potentially allow better prediction response to protein-1–targeted therapies. Imaging is feasible by with adnectin protein <sup>18</sup>F-BMS-986192. However, radiofluorination proteins such as BMS-986192 remains complex labeling yields are low. The goal this study was...
The small bacteriophage phi29 must penetrate the approximately 250-A thick external peptidoglycan cell wall and membrane of Gram-positive Bacillus subtilis, before ejecting its dsDNA genome through tail into bacterial cytoplasm. is noncontractile 380 A long. 1.8-A resolution crystal structure gene product 13 (gp13) shows that this protein has spatially well separated N- C-terminal domains, whose structures resemble lysozyme-like enzymes metallo-endopeptidases, respectively. CryoEM...
Abstract Purpose: BRAF-inhibition (BRAFi) therapy for advanced melanoma carries a high rate of secondary cutaneous squamous cell carcinoma (cSCC) and risk other cancers. UV radiation α-genus human papillomavirus (HPV) are highly associated with SCC, but novel role β-genus HPV is suspected in BRAFi-cSCC. Cutaneous β-HPV may act concert host environmental factors Experimental Design: Primary BRAFi-cSCC tissue DNA isolated from patients receiving vemurafenib or dabrafenib two cancer centers was...
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The transcription factor TCF7L1 is an embryonic stem cell signature gene that upregulated in multiple aggressive cancer types, but its role skin tumorigenesis has not yet been defined. Here we document upregulation squamous carcinoma (SCC) and demonstrate overexpression increases tumor incidence, multiplicity, malignant progression the chemically induced mouse model of SCC. Additionally, show downregulation paralogue TCF7L2 reduces growth a xenograft human Using separation-of-function...
Seventeen days after double lung transplantation, a 56-year-old patient with idiopathic pulmonary fibrosis developed respiratory distress. Imaging revealed bilateral infiltrates pleural effusions and physical examination demonstrated sternal instability. Broad-spectrum antibacterial antifungal therapy was initiated thoracotomy tubes were placed. Both right left cultures grew mold subsequently identified as Scopulariopsis brumptii. The underwent irrigation debridement three times but wound...
The precise and unambiguous elucidation characterization of interactions between a high affinity recognition entity its cognate protein provides important insights for the design development drugs with optimized properties efficacy. In oncology, one target has been shown to be epidermal growth factor receptor (EGFR) through therapeutic anticancer antibodies that are selective inhibitors EGFR activity. More recently, smaller derived from 10th type III domain human fibronectin termed an...
Proliferating tricholemmal tumors (PTTs) are rare benign neoplasms that arise from the outer sheath of a hair follicle. Occasionally, these PTTs undergo malignant transformation to become proliferating (MPTTs). Little is known about molecular alterations, progression, and management MPTTs. Here, we describe case 58-year-old female had widely metastatic MPTT harbored an activating PIK3CA mutation was sensitive PI3K inhibitor, alpelisib (BYL719). We review available literature on MPTT, detail...
Background R h IG is used worldwide to reduce the incidence of alloimmunization D during pregnancy. We report a case clinically significant neonatal hemolysis mediated by maternally administered RhIG . Case Report A 25‐year‐old, O –, primigravid mother with negative antenatal antibody screen delivered 6‐lb 4‐oz, blood group , + baby girl at 36.5 weeks' gestation. Prenatal care included dose intramuscular 28 At delivery, newborn was markedly jaundiced total bilirubin 6.3 mg/ dL which reached...
Sepsis-induced coagulopathy leading to disseminated microvascular thrombosis is associated with high mortality and has no existing therapy. Despite the prevalence of Gram-positive bacterial sepsis, especially methicillin-resistant