A5042007085- Gut microbiota and health
- Microbial Natural Products and Biosynthesis
- Animal Virus Infections Studies
- Antifungal resistance and susceptibility
- Viral gastroenteritis research and epidemiology
- Crystallization and Solubility Studies
- Clostridium difficile and Clostridium perfringens research
- Drug Transport and Resistance Mechanisms
- Antibiotic Resistance in Bacteria
- Biochemical and Molecular Research
- X-ray Diffraction in Crystallography
- Titanium Alloys Microstructure and Properties
- Hydrogen embrittlement and corrosion behaviors in metals
- Salivary Gland Disorders and Functions
- RNA Interference and Gene Delivery
- Probiotics and Fermented Foods
- Venous Thromboembolism Diagnosis and Management
- SARS-CoV-2 and COVID-19 Research
- Bioinformatics and Genomic Networks
- Acute Myocardial Infarction Research
- IL-33, ST2, and ILC Pathways
- Antibiotics Pharmacokinetics and Efficacy
- Liver Diseases and Immunity
- Virus-based gene therapy research
- Gout, Hyperuricemia, Uric Acid
Lanzhou Veterinary Research Institute
2025
Chinese Academy of Agricultural Sciences
2025
Gansu Provincial Center for Disease Control and Prevention
2025
Lanzhou University
2025
Shenzhen Bay Laboratory
2024-2025
Peking University
2011-2024
Dalian Medical University
2024
Huazhong Agricultural University
2024
Beijing National Laboratory for Molecular Sciences
2017-2024
Polish Academy of Sciences
2024
ConspectusProgrammed cell death (PCD) is fundamentally an indispensable process in all cellular activities, including development, wound healing, and immune surveillance of tumors (Galluzzi, L. et al. Cell Death Differ. 2018, 25, 486−541). Malfunctioning PCD has been shown to be closely related human diseases such as acute pancreatitis, neurodegenerative diseases, diverse types cancers. To date, multiple processes have discovered the corresponding regulatory pathways elucidated. For example,...
ABSTRACT Porcine deltacoronavirus (PDCoV) is an emerging porcine enteric coronavirus causing significant economic losses to the pig farming industry globally. In this study, we expressed S protein of a highly virulent PDCoV strain in CHO eukaryotic expression system. After immunizing alpaca with and employing phage display library technique, high-affinity specific nanobody Nb3 against was successfully established by three rounds biopanning enzyme-linked immunosorbent assay (ELISA)....
The urate transporter 1 (URAT1) is the primary in kidney responsible for reabsorption and, therefore, crucial homeostasis. Hyperuricemia causes common human disease gout and other pathological consequences. Inhibition of through URAT1 has been shown as a promising strategy alleviating hyperuricemia, clinical preclinical drug candidates targeting are emerging. However, how small molecules inhibit remains undefined, lack accurate complex structures hinders development better therapeutics....
Staphylopine was discovered and functionally evaluated as a novel type of metallophore that Staphylococcus aureus employs to acquire multiple divalent transition metals. Aspergillomarasmine A (AMA), with similar structure staphylopine, recently identified an inhibitor metallo-β-lactamases NDM-1 VIM-2. Herein, we report unified approach using Mitsunobu reaction key step accomplish the concise efficient total syntheses staphylopine AMA. We also elucidate broad-spectrum metal chelation...
The first total synthesis and isolation of pseudopaline was reported, which allows determination confirmation the absolute configuration natural product.
Bile acids are essential metabolites and signaling molecules in mammals. Primary bile synthesized from cholesterol the liver. At same time, microbiota mammalian gut has many interactions with acid, including various biotransformation processes such as 7-dehydroxylation 3-epimerization. 7-Dehydroxylation is mediated by a acid-inducible (bai) operon, while 3-epimerization independently observed only few strains. Herein, we describe novel microbe, Dorea sp. AM58-8, that can accomplish two-step...
β-Lactam antibiotic resistance has become a critical global health threat. One of the major reasons for drug is expression β-lactamases especially metallo-β-lactamases such as New Delhi metallo-β-lactamase (NDM-1) by Gram-negative bacteria. The fungal natural product aspergillomarasmine A (AMA) was found to be promising inhibitor NDM-1 potentiate currently used β-lactam antibiotics overcome both in vitro and vivo. Although several chemical synthesis chemoenzymatic approaches access AMA have...
The single‐dose disposition kinetics of the antibiotic marbofloxacin were determined in C hinese soft‐shelled turtles ( n = 10) after oral and intramuscular (i.m.) dose 10 mg/kg bodyweight. vitro ex vivo activities serum against a pathogenic strain A eromonas hydrophila determined. concentration‐dependent antimicrobial activity was confirmed for levels lower than 4 × MIC . For PK data, values AUC : minimum inhibitory concentration ) ratio 1166.6 782.4 h, respectively, i.m. dosing 0.05...
Background Targeted therapy for Sjögren’s syndrome (SS) has become an important focus clinicians. Multi-omics-wide Mendelian randomization (MR) analyses have provided new ideas identifying potential drug targets. Methods We conducted summary-data-based (SMR) analysis to evaluate therapeutic targets associated with SS by integrating DNA methylation, gene expression and protein quantitative trait loci (mQTL, eQTL, pQTL, respectively). Genetic associations were derived from the FinnGen study...
To investigate the optimal anticoagulation methods and monitoring strategy for Chinese patients undergoing heart valve replacement, which is potentially quite different from western populations.In this multicenter prospective cohort study, data was acquired 25 773 in-hospital in 35 medical centers 20 519 outpatient clinic 11 January 1st, 2011 to December 31th, 2015.As patients, mean age of study population (48.6±11.2) years old; main etiology pathology rheumatic (87.5%) origin among cohort;...
1. EFSA FEEDAP Panel., 2019. Safety and efficacy of Probion forte®(Bacillus subtilis KCCM 10941P Bacillus coagulans 11093P) for chickens fattening. J. 17, e05644, https://doi.org/10.2903/j.efsa... CrossRef Google Scholar
Abstract Probiotics play a crucial role in regulating the gut microbiota and enhancing immune response. Oral administration of probiotics modulates intestinal composition homeostasis. In this study, we investigated immunoregulatory effect Lacticaseibacillus rhamnosus LRa05 on cyclophosphamide (CTX)‐induced immunosuppressive mice. The results showed that oral reduced weight loss, restored organ indices, maintained structural integrity tissue CTX‐treated Moreover, exhibited immune‐modulating...
Objective: To evaluate the prognostic value of left ventricular ejection fraction (LVEF) reserve assessed by gated SPECT myocardial perfusion imaging (SPECT G-MPI) for major adverse cardiovascular event (MACE) in patients with coronary artery disease. Methods: This is a retrospective cohort study. From January 2017 to December 2019, disease and confirmed ischemia stress rest G-MPI, underwent angiography within 3 months were enrolled. The sum score (SSS) resting (SRS) analyzed standard...