A5056198001- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- Acute Myocardial Infarction Research
- Escherichia coli research studies
- Data-Driven Disease Surveillance
- Hepatitis Viruses Studies and Epidemiology
- Venous Thromboembolism Diagnosis and Management
- COVID-19 epidemiological studies
- Immune responses and vaccinations
- Atrial Fibrillation Management and Outcomes
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
Hunan Province Chest Hospital
2024
Central South University
2022-2024
Center for Tuberculosis Control of Guangdong Province
2016-2022
Hunan Provincial Center for Disease Control and Prevention
2016-2022
The worldwide emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant (XDR-TB) has posed additional challenges for global (TB) control efforts, as limited treatment options are available outcomes often sub-optimal. This study determined among a cohort MDR-TB XDR-TB patients in Hunan Province, China, identified factors associated with poor outcomes. We conducted retrospective using data obtained from medical records TB Chest Hospital, the internet-based...
Abstract Objectives Globally, China has the third highest number of tuberculosis (TB) cases despite high rates (85.6%) effective treatment coverage. Identifying risk factors associated with unsuccessful outcomes is an important component maximising efficacy TB control programmes. Methods Retrospective cohort study to evaluate 306,860 drug‐susceptible patients who underwent in Hunan Province, between 2013 and 2018. Univariable multivariable logistic regression models were used identify...
Prospective population data on the incidence of tuberculosis (TB) infection has been sparsely reported in global literature.A population-based prospective study was conducted rural China to investigate annual risk TB infection, and its persistence using serial tuberculin skin tests (TSTs) an interferon-γ release assay. In total, 13 580 eligible participants from four sites, identified as TST negative (<10 mm) or QuantiFERON-TB Gold In-Tube (QFT) (an assay) a baseline survey, were included...
Tuberculosis (TB) is the leading cause of death from a bacterial pathogen worldwide. China has third highest TB burden in world, with high reported Hunan Province (amongst others). This study aimed to investigate spatial distribution and identify socioeconomic, demographic, environmental drivers Province, China. Numbers cases were obtained Control Institute A wide range covariates collected different sources, including Worldclim database, Bureau Statistics. These variables summarized at...
Abstract Background Multidrug-resistant tuberculosis (MDR-TB) is a global health threat associated with high morbidity and mortality rates. Diagnosis treatment delays are poor outcomes in patients MDR-TB. However, the risk factors these not robustly investigated, particularly TB burden countries such as China. Therefore, this study aimed to measure length of diagnosis identify their among MDR-TB Hunan province. Methods A retrospective cohort was conducted using data from province between...
Background The World Health Organization (WHO) has conditionally recommended the use of sputum smear microscopy and culture examination for monitoring multidrug-resistant tuberculosis (MDR-TB) treatment. We aimed to assess compare validity conversion at different time points during treatment MDR-TB, as a prognostic marker end-of-treatment outcomes. Methods undertook retrospective observational cohort study using data obtained from Hunan Chest Hospital, China Gondar University Ethiopia....
In 2015, only 49% of notified multi-drug resistant tuberculosis (MDR-TB) patients in China were estimated to have initiated treatment, compared with 90% those worldwide. A case-control study was conducted identify the reasons for non-enrollment treatment among MDR-TB Hunan province, China. All detected registered designated hospitals province from 2011 2014 included and followed until June 2015 determine their status. Approximately 33.8% (482/1425) not enrolled standardized treatment....
This study aimed to investigate the spatial distribution of drug-resistant tuberculosis (DR-TB) in Hunan province, China.An ecological was conducted using DR-TB data collected from Tuberculosis Control Institute Province between 2012 and 2018. Spatial clustering explored Getis-Ord statistic. A Poisson regression model fitted with a conditional autoregressive prior structure, posterior parameters estimated Bayesian Markov chain Monte Carlo simulation, quantify associations possible risk...
Abstract Background Tuberculosis (TB) continues to be a major public health challenge in China. Understanding TB management delays within the context of China’s unique ethnic diversity may value tackling disease. This study sought evaluate impact minority status on diagnosis and treatment delays. Methods retrospective cohort was conducted patients diagnosed with Hunan Province, China between 2013 2018. Diagnosis delay defined as time interval onset symptoms date diagnosis. Treatment...
Abstract Background Drug-resistant tuberculosis (DR-TB) is a major public health threat in Hunan Province, with an increasing clinical burden recent years. This study aimed to identify socio-demographic and factors associated DR-TB province, China. Methods A case-control was conducted province. Cases were all patients who confirmed by culture Drug susceptibility testing (DST) enrolled at the treatment center of Chest Hospital from 2013 2018. Controls Susceptible TB (DS-TB) DST same hospital...
To investigate the optimal anticoagulation methods and monitoring strategy for Chinese patients undergoing heart valve replacement, which is potentially quite different from western populations.In this multicenter prospective cohort study, data was acquired 25 773 in-hospital in 35 medical centers 20 519 outpatient clinic 11 January 1st, 2011 to December 31th, 2015.As patients, mean age of study population (48.6±11.2) years old; main etiology pathology rheumatic (87.5%) origin among cohort;...
Background Treatment outcomes among patients treated for multidrug-resistant tuberculosis (MDR-TB) are often sub-optimal. Therefore, the early prediction of poor treatment may be useful in patient care, especially clinicians when they have ability to make decisions or offer counselling additional support patients. The aim this study was develop a simple clinical risk score predict with MDR-TB, using routinely collected data from two large countries geographically distinct regions. Methods We...
Background: Drug-resistant tuberculosis (DR-TB) remains a major public health challenge in China, with varying treatment outcomes across different regions. Understanding the spatial distribution of DR-TB is crucial for targeted interventions to improve success high-burden areas such as Hunan Province. This study aimed map at local level and identify sociodemographic environmental factors associated poor Province, China. Methods: A analysis was conducted using data from Tuberculosis Control...
Pulmonary tuberculosis (PTB) is a major infectious disease that threatens human health. China high tuberculosis-burden country and the Hunan Province has notification rate. However, no comprehensive analysis been conducted on spatiotemporal distribution of PTB in Province. Therefore, this study investigated to enable targeted control policies for tuberculosis. We obtained data about cases notified from January 2014 December 2022 Information System Disease Control Prevention. Time-series was...
Reducing mortality during anti-tuberculosis treatment is crucial for completing full-course standardized therapy and achieving tuberculosis cure. The study aims to analyze the its influencing factors among pulmonary patients undergoing in Hunan Province. In this retrospective cohort study, data on from Provincial Tuberculosis Management Information System were collected between January 1, 2019 December 31, 2023. cumulative survival rate was estimated using life table methods. Survival rates...
Tuberculosis (TB) seriously threatens individual and public health. Recently, TB outbreaks in schools have been reported more frequently China attracted widespread attention. We three high Hunan Province, China.When a tuberculosis patient was school, we carried out field epidemiological investigations, including tuberculin skin testing (TST), chest X-ray (CXR) laboratory test for all close contacts, whole-genome sequencing (WGS) analyses to understand the transmission patterns, causes risk...
Objective To investigate the prevalence of tuberculosis (TB) in human immunodeficiency virus (HIV) positive population and explore its influencing factors. Methods Cluster sampling was used, continuous 205 cases who were diagnosed as HIV from December 16, 2002 to June 30, 2012 Zhuhui district Yanfeng Hunan province could be followed up traced enrolled study. All patients screened after informed content through questionnaire, sputum smear examination, chest X-ray liquid culture...