A5101967517- Heart Rate Variability and Autonomic Control
- EEG and Brain-Computer Interfaces
- Non-Invasive Vital Sign Monitoring
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Functional Brain Connectivity Studies
- Bone health and osteoporosis research
- Neuroscience of respiration and sleep
- Electromagnetic Fields and Biological Effects
- Educational Reforms and Innovations
- Blood properties and coagulation
- High Altitude and Hypoxia
- Rheology and Fluid Dynamics Studies
- Mitochondrial Function and Pathology
- Cellular Mechanics and Interactions
- Phytochemicals and Antioxidant Activities
- Erythrocyte Function and Pathophysiology
- Polysaccharides and Plant Cell Walls
- Bone Metabolism and Diseases
- Cancer Cells and Metastasis
- Atrial Fibrillation Management and Outcomes
- Stress Responses and Cortisol
- Seaweed-derived Bioactive Compounds
- Heat shock proteins research
- Medical Research and Treatments
Xi'an Jiaotong University
2015-2025
Eighth Affiliated Hospital of Sun Yat-sen University
2021-2024
Sun Yat-sen University
2021-2024
Guangzhou Academy of Special Equipment Inspection and Testing
2022
China Waterborne Transport Research Institute
2018
Ministry of Education of the People's Republic of China
2016
Wuhan University
2009
University of Maryland, Baltimore
2009
Baltimore VA Medical Center
2009
Renmin Hospital of Wuhan University
2009
Postmenopausal women face increased risks of osteoporosis and cardiovascular diseases due to estrogen decline. This study investigated the effects moderate-intensity continuous training (MICT) high-intensity interval (HIIT) on bone microstructure risk factors in ovariectomized (OVX) mice. Results showed that both exercise regimens improved blood lipid profiles vascular structure, reducing systolic pressure (−11.81% −10.89%) undercarboxylated osteocalcin (ucOCN) levels (−52.14% −52.05%)....
Early (E9.5–E11.5) embryonic heart cells beat spontaneously, even though the adult pacemaking mechanisms are not yet fully established. Here we show that in isolated murine early cardiomyocytes periodic oscillations of cytosolic Ca2+ occur and these induce contractions. The originate from sarcoplasmic reticulum dependent on IP3 ryanodine receptor. activate Na+-Ca2+ exchanger, giving rise to subthreshold depolarizations membrane potential and/or action potentials. Although voltage-independent...
Mental arithmetic has been verified inducing cerebral and cardiovascular responses. However, the mechanism sequential responses are still ambiguous. This study aims to reveal of autonomic related scalp positions that regulate nerves system (ANS) during MA task. 34 healthy male subjects aged between 19 27 years old (mean age 23.6 ± 2.3 years) were recruited in. Electrocardiogram, impedance cardiography, beat-to-beat blood pressure electroencephalography measured simultaneously continuously...
Pulsed electromagnetic fields (PEMF) can be used to treat bone-related diseases, but the underlying mechanism remains unclear, especially process by which PEMFs initiate biological effects. In this study, we demonstrated effects of PEMF on proliferation and differentiation osteoblasts using model calcium transients induced high extracellular calcium. Our results showed that increase both percentage responding cells amplitude intracellular stimulation. Compared with corresponding levels,...
As an immune checkpoint protein expressed by diverse cancer cells, programmed death ligand 1 (PD-L1) facilitates evasion interacting with cell death-1 (PD-1) on T cells. Despite the clinical benefits observed in various types, strategies targeting PD-1/PD-L1 have demonstrated limited efficacy gastric (GC). Furthermore, regulation of PD-L1, especially at post-translational modification levels, remains largely unknown. Therefore, it is crucial to elucidate mechanisms governing PD-L1 expression...
The increasing prevalence of acute noise exposure poses a significant threat to mental health. Identifying the intensity that impair health is crucial for developing effective interventions. study aimed determine thresholds elicit anxiety-like behaviors and brain damage in female rats, then elucidate underlying neurobiological mechanisms. Female rats were subjected at levels 105, 115, 125, 135 dB assessed 3th day 1 month post-exposure. We found induced hippocampal neuron apoptosis on third...
Despite numerous reports documenting an important role of hypertension in the development atrial fibrillation (AF), detailed mechanism underlying pathological process remains incompletely understood. Here, we aim to test hypothesis that diastolic sarcoplasmic reticulum (SR) Ca2+ leak myocytes, induced by mechanical stretch due elevated pressure left atrium (LA), plays essential AF pressure-overloaded hearts.
It is well known that the extremely low-frequency electromagnetic field (EMF) can promote healing of bone fractures, but its mechanism remains poorly understood. The purpose this study was to examine response neonatal rat calvarial cells rectangular (REMF), triangular (TEMF), sinusoidal (SEMF), and pulsed (PEMF). stimulatory effects EMF were evaluated by proliferation (methyltetrazolium colorimetric assay), differentiation (alkaline phosphatase (ALP) activity), mineralization (area...
Abstract Aims As the ovaries age and women transition to menopause postmenopause, reduced estradiol levels are associated with anxiety depression. Exercise contributes alleviate depression bone‐derived hormone osteocalcin has been reported be necessary prevent anxiety‐like behaviors. The aim of this study was investigate effects exercise on behaviors in climacteric mice whether it related osteocalcin. Methods Menopausal mouse model induced by intraperitoneal injection 4‐vinylcyclohexene...
Calcium transients play an essential role in cardiomyocytes and electromagnetic fields (EMF) affect intracellular calcium levels many types of cells. Effects EMF on are not well studied. The aim this study was to assess whether extremely low frequency (ELF-EMF) could cardiomyocytes. Cardiomyocytes isolated from neonatal Sprague-Dawley rats were exposed rectangular-wave pulsed ELF-EMF at four different frequencies (15 Hz, 50 75 Hz 100 Hz) a flux density 2 mT. Intracellular concentration...
Numerous studies have demonstrated that fluid shear stress (FSS) may promote the proliferation and differentiation of osteoblast cells. However, are mutually exclusive processes unlikely to be promoted by FSS simultaneously. Cell induced has rarely been reported. In order provide an insight into this process, present study investigated effects on osteoblast‑like MC3T3 cells in G0/G1 phase, period during which fate a cell is determined. The results alkaline phosphatase (ALP) activity, mRNA...
Noninvasive assessment of autonomic nervous system (ANS) activity is great importance, but the accuracy method used, which primarily based on electrocardiogram-derived heart rate variability (HRV), has long been suspected. We investigated feasibility photoplethysmography (PPG) in ANS evaluation. Data 32 healthy young men under four different activation patterns were recorded: baseline, slow deep breathing (parasympathetic activation), cold pressor test (peripheral sympathetic and mental...
During bone remodeling, high extracellular calcium levels accumulated around the resorbing tissue as soon activation of osteoclasts. However, if and how is involved in regulation remodeling remains unclear. In this study, effect concentrations on osteoblast proliferation differentiation, intracellular ([Ca2+]i) levels, metabolomics, expression proteins related to energy metabolism were investigated. Our results showed that initiated a [Ca2+]i transient via calcium-sensing receptor (CaSR)...