A5039893802- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Immunotherapy and Immune Responses
- Bee Products Chemical Analysis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Organ Transplantation Techniques and Outcomes
- Mechanical Circulatory Support Devices
- RNA Interference and Gene Delivery
- Toxin Mechanisms and Immunotoxins
- Lung Cancer Diagnosis and Treatment
- Cardiac Fibrosis and Remodeling
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- PI3K/AKT/mTOR signaling in cancer
- CAR-T cell therapy research
- Sarcoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Lung Cancer Treatments and Mutations
- Single-cell and spatial transcriptomics
- Cardiovascular and exercise physiology
- Nitric Oxide and Endothelin Effects
- Head and Neck Cancer Studies
- Metabolomics and Mass Spectrometry Studies
Capital Medical University
2013-2024
Beijing Ditan Hospital
2014-2024
Sun Yat-sen University
2024
Eighth Affiliated Hospital of Sun Yat-sen University
2024
Beijing YouAn Hospital
2021
Beijing Chao-Yang Hospital
2019
Nankai University
2013-2014
Capital University
2014
First Hospital of Xi'an
2013
Abstract Solid tumors are complex ecosystems with heterogeneous 3D structures, but the spatial intra-tumor heterogeneity (sITH) at macroscopic (i.e., whole tumor) level is under-explored. Using a phylogeographic approach, we sequence genomes and transcriptomes from 235 spatially informed sectors across 13 hepatocellular carcinomas (HCC), generating one of largest datasets for studying sITH. We find that tumor in HCC segregates into variegated blocks large genotypic phenotypic differences. By...
As an immune checkpoint protein expressed by diverse cancer cells, programmed death ligand 1 (PD-L1) facilitates evasion interacting with cell death-1 (PD-1) on T cells. Despite the clinical benefits observed in various types, strategies targeting PD-1/PD-L1 have demonstrated limited efficacy gastric (GC). Furthermore, regulation of PD-L1, especially at post-translational modification levels, remains largely unknown. Therefore, it is crucial to elucidate mechanisms governing PD-L1 expression...
Nasopharyngeal cancer (NPC) is a common head and neck malignant tumor, which difficult to treat at the advanced NPC due its occult high metastatic potential cervical lymph nodes distant organs. Low-dose radiotherapy (LDRT) increasingly being investigated for treatment. When combined with immune checkpoint inhibitors, LDRT has been shown significantly improve microenvironment of tumors, thereby promote attack on tumor cells. However, therapeutic effect immunotherapy in not well understood. We...
BACKGROUND Most non-small cell lung cancer patients have epidermal growth factor receptor (EGFR) activating mutations, such as exon 19 deletion and 21 replacement mutations. Osimertinib is a third-generation EGFR-tyrosine kinase inhibitors approved for the treatment of carrying EGFR Osimertinib-induced interstitial disease (ILD) rare potentially fatal pulmonary toxic manifestation drug therapy. At present, there no international consensus on risks osimertinib-induced ILD. CASE SUMMARY We...
Extensive data have shown that exercise training can provide cardio-protection against pathological cardiac hypertrophy. However, how long the heart retain cardio-protective phenotype after cessation of is currently unknown. In this study, we investigated time course loss and signaling molecules are responsible for possible sustained protection. Mice were made to run on a treadmill six times week 4 weeks then rested period 0, 1, 2 followed by isoproterenol injection 8 days. Morphological,...
Phosphoinositide-3-kinase α (PI3Kα) represents a potential novel drug target for pathological cardiac hypertrophy (PCH) and heart failure. Oligodeoxynucleotides containing CpG motifs (CpG-ODN) are classic agonists of Toll-like receptor 9 (TLR9), which typically activates PI3K-Akt signaling in immune cells; however, the role nucleotide TLR9 myocytes is largely unknown. Here we report that CpG-ODN C274 could both attenuate PCH improve dysfunction by activating PI3Kα-Akt cascade. In vitro...
Retroperitoneal schwannomas are a rare disease. During the potent antiretroviral therapy era, incidence of AIDS-defining cancers has decreased, while non-AIDS defining increased; however, existence relationship between benign or malignant and AIDS remains unclear. Although case ethmoid schwannoma in an patient was first reported 1993, no additional reports associated with have been published since. In current study, 30-year-old male large retroperitoneal is presented. The ideal treatment...
Purpose: This study aimed to evaluate the safety and effectiveness of simultaneous radiofrequency ablation (RFA) combined with laparoscopic splenectomy (Lap-Sp) for patients hepatocellular carcinoma (HCC) complicated cirrhosis hypersplenism.Material methods: Between January 2013 June 2014, 42 primary HCC hypersplenism who underwent RFA Lap-Sp were enrolled at Department General Surgery, Beijing Di Tan Hospital. The median number tumors ablated using was one (range 1–3), sum maximum diameter...
Bao-Yuan-Ling (BYL) is an apitherapy formulation which composed of royal jelly, propolis and bee venom. Cardioprotective effects BYL has been demonstrated, while the toxicity was not clear. In this study, acute sub-acute test processed following Organization for Economic Co-operation Development (OECD) 423 OECD 407, respectively, in Wistar rats. test, rats were orally treated with at single dose 2000 mg/kg 5000 mg/kg. No death occurred 7 days, indicated lethal 50% value exceeded 250 mg/kg,...
2009年5月15日-6月22日期间北京地坛医院收治了7例甲型H1N1流感无症状感染(asymptomatic infection)者,现将其临床经过报告如下. 一、资料与方法 共收治33例甲型H1N1流感病毒感染者,对其中的7例无症状感染者进行研究。
作为肝脏终末期疾病和急性肝衰竭的有效治疗手段,肝脏移植已愈发体现出其不可替代的临床价值.但由于同种异体肝移植术后的排斥反应,使其成为左右移植器官功能的关键.因此, 针对排斥反应机制及相关治疗的探讨一直是各国移植工作者研究的重点之一.作为目前已知最为强大的抗原提呈细胞(APCs)-树突状细胞(DCs)在肝移植术后对维系免疫耐受状态所起的重要作用,已经成为科研人员研究的焦点问题.本文就树突状细胞在肝移植术后诱导免疫耐受的机制,以及近年来相关的研究进展概述如下。