A5012001115- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Signaling Pathways in Disease
- Acute Myeloid Leukemia Research
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Interprofessional Education and Collaboration
- Healthcare professionals’ stress and burnout
- Calpain Protease Function and Regulation
- Lung Cancer Research Studies
- Myasthenia Gravis and Thymoma
- Nursing Diagnosis and Documentation
- High Altitude and Hypoxia
- PI3K/AKT/mTOR signaling in cancer
- Social Work Education and Practice
- MRI in cancer diagnosis
- Retinoids in leukemia and cellular processes
- Workplace Health and Well-being
- Immunotherapy and Immune Responses
Capital Medical University
2013-2025
Henan Provincial People's Hospital
2020-2024
Sun Yat-sen University
2017-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2024
Kunming Children's Hospital
2024
Beijing Ditan Hospital
2014-2023
Hangzhou First People's Hospital
2021
Sun Yat-sen University Cancer Center
2020
State Key Laboratory of Oncology in South China
2020
Shenzhen Institute of Innovation Design (China)
2020
Growth arrest special 5 (GAS5) is a long non-coding RNA reported to function as an inhibitor in various tumors including cervical cancer. However, the molecular mechanism of GAS5 involved cancer progression remains far from being elucidated. The expression GAS5, forkhead box protein O1 and phosphatase tensin homolog was examined by quantitative reverse transcription polymerase chain reaction qRT-PCR. cell growth, invasion, apoptosis were assessed...
T cell exhaustion is an obstacle to immunotherapy for solid tumors. An understanding of the mechanism by which cells develop this phenotype in tumors needed. Here, hypoxia, a feature tumor microenvironment, causes (TExh) inducing mitochondrial defect. Upon exposure activated with TExh are characterized fragmentation, decreased ATP production, and oxidative phosphorylation activity. The correlated downregulation fusion protein mitofusin 1 (MFN1) upregulation miR-24. Overexpression miR-24...
Emerging evidence has showed that long non-coding RNA (lncRNA) play an important role in the occurrence and development of various cancers. In present study, expression level lincRNA-p21 was investigated hepatocellular carcinoma (HCC), its invasion HCC also explored.The levels human tumor tissue cell lines HepG2 SMMC-7721 were determined by real-time polymerase chain reaction. Transfected cells with pcDNA-lincRNA-p21 or si-lincRNA-p21 for overexpression downregulation lincRNA-p21, Notch...
This study aims to figure out the methylation of long non-coding RNA GAS5 promoter in cervical cancer and mechanism on progression cells. The expression state tissues cells were determined. With aim explore ability proliferation, cell cycle progression, apoptosis, invasion, migration as well tumor growth, metastasis nude mice was decreased elevated cancer. Overexpression inhibited while inducing apoptosis suppressed growth mice. Our demonstrates that abnormal contributes poor In addition,...
SUMO-activating enzyme subunit 2 (SAE2) is the sole E1-activating required for numerous important protein SUMOylation, abnormal of which associated with carcinogenesis. SAE2 inactivation was recently reported to be a therapeutic strategy in cancers Myc overexpression. However, roles small cell lung cancer (SCLC) are largely unknown. Stably knockdown H446 cells were established lentiviral system. Cell viability, cycle, and apoptosis analyzed using MTT assay flow cytometric assay. Expression...
ABSTRACT Schwannoma surgeries pose a significant risk of postoperative neurological impairment. While intraoperative neuromonitoring (IONM) has improved surgical outcomes, it offers an indirect assessment neural structures and functions. However, during the surgeries, is not feasible to achieve comprehensive visualization nerves. To address this limitation, we introduced multi‐channel flexible microelectrode array (FMEA) characterized by its exceptional resolution, consistent conductivity,...
Cervical cancer is the second most common type of and third leading cause deaths in females developing countries. Recent studies showed that long non-coding RNAs play a key role human cancers. However, molecular mechanisms underlying initiation progression cervical remained to be further explored.In this study, we explored differential expression lncRNAs mRNAs by analyzing public dataset GSE63514. Next, PPI co-expression networks were constructed reveal potential roles related lncRNAs....
Mesoporous silica nanoparticles (MSNs) are widely used with a pore rich structure that is suitable for drug delivery. Here, we MSNs to carry and deliver doxorubicin hydrochloride (DOX) in vivo study the features of DOXloaded (MSNs@DOX). We TEM zeta potential illustrate MSNs@DOX increase apoptosis decrease metastasis tumor cells. MTT, flow cytometry, Western blotting, wound healing, transwell assays, as well an model explore anti-carcinoma efficacy MSNs@DOX. Our results showed DOX was...
Liver resections for hepatocellular carcinoma (HCC) in cirrhotic livers are associated with early recurrence and poor survival. Somatostatin analogues (SSAs) have been reported to inhibit cell proliferation by interacting specific somatostatin receptors (SSTRs) 2 5. The present study investigated whether SSTR expression HCC was the clinical outcome following octreotide long‑acting release (LAR) treatment. Paired tumor liver samples were obtained a resection from 99 patients stage I‑II...
CYP2W1 overexpression has been reported in a variety of human cancers. However, the role hepatocellular carcinoma (HCC) remains unclear. This study was designed to evaluate expression and prognostic significance HCC. Real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) conducted detect messenger RNA (mRNA) 41 pairs fresh-frozen HCC tissues adjacent noncancerous tissues. In addition, analyzed by immunohistochemistry 133 clinicopathologically characterized cases....
Background/Aims: Gastric cancer is a highly aggressive tumor containing stem cells (CSCs), which participate in initiation, therapeutic resistance, and relapse. Proline-rich protein 11 (PRR11) has been shown to be up-regulated human cancers; however, its role gastric CSCs unknown. We hypothesize that PRR11 may affect tumorigenicity of CSCs. In this study, we explored the biological function regulation Methods: Expression was evaluated CSC cell line by real-time quantitative PCR western blot....
Background: Transarterial chemoembolization (TACE) represents a widely accepted treatment procedure for intermediate stage or unresectable hepatocellular carcinoma (HCC). However, few studies have evaluated serologic prognosis factors in patients with HCC before TACE. Secreted protein acidic and rich cysteine (SPARC) is matricellular glycoprotein affecting tumorigenesis metastasis, leading to poor HCC. Therefore, further explore the potential value of SPARC, expression levels plasma its...
Mounting evidence has shown that circular RNAs (circRNAs) function as key regulators in carcinogenesis and cancer progression, this study is aimed at investigating the regulatory functions of circRNA TLK1 (circ-TLK1) hepatocellular carcinoma (HCC). We observed circ-TLK1 was highly expressed HCC samples, its high expression closely associated with poor clinicopathological variables patients. The results functional experiments revealed knockdown remarkably inhibited proliferation, migration,...
Long non‑coding RNAs (lncRNAs) have been implicated in the development and progression of tumors. However, roles underlying mechanisms long intergenic non‑protein coding RNA 1116 (LINC01116), a member lncRNA family, glioma are largely unclear. The expression LINC01116 microRNA (miR)‑744‑5p tissues cells was detected by reverse transcription‑quantitative PCR. influences or miR‑744‑5p on cell proliferation invasion were evaluated Cell Counting Kit‑8, colony formation Transwell assays, western...
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. Circulating tumor cells (CTCs) are considered a major cause recurrence and metastasis in cancer; however, detection CTCs challenging owing to their very low numbers peripheral blood (around 10 per 1,000,000 erythrocytes). Cancer‑testis antigens (CTAs) specific markers for CTCs. The present study aimed evaluate sensitivity specificity reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) nine...
In order to explore the prognostic value of CD2, CD4, and human leucocyte antigen-DR (HLA-DR) expression Fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutation in leukemia cells bone marrow patients with acute promyelocytic (APL), we retrospectively collected analyzed immunophenotype, molecular features clinical characteristics 219 newly diagnosed adult APL Henan Provincial People's Hospital from January 2010 December 2019. It turned out that relapse rates or HLA-DR early...
The present study aimed to identify whether FK506 suppresses hypoxia‑induced inflammation and protects tight junction function via the calcineurin‑nuclear factor of activated T‑cells 1 (CaN‑NFATc1) signaling pathway in mouse retinal microvascular endothelial cells (mRMECs). mRMECs were treated with at different concentrations following induction hypoxia. Trans‑epithelial electrical resistance (TEER) cell permeability examined measure integrity junctions. inflammatory cytokines measured using...
Patients with hepatocellular carcinoma complicated main portal vein tumor thrombosis (mPVTT) and cirrhotic hypertension (CPH) have an extremely poor prognosis, there is a lack of clinically effective treatment paradigm.To evaluate the efficacy safety transjugular intrahepatic portosystemic shunt (TIPS) combined radioactive seed strand for mPVTT patients CPH.The clinical data 83 consecutive who underwent TIPS 125I placement CPH from January 2015 to December 2018 were retrospectively reviewed....
Inhibitors of histone deacetylase enzymes induce various molecular and extracellular effects that lead to their anticancer role. In this study, the result valproic acid on expression genes extrinsic pathway intrinsic apoptosis, cell viability, apoptosis in liver cancer PLC/PRF5 line was designed. For purpose, cells were cultured, after overlapping reached about 80%, collected with trypsin washing, they cultured a plate concentration 3 x 105. After 24 hours, culture medium treated containing...
This paper uses Taylor's emancipatory reflection model to examine an ethical issue involving nurses' rights, that is, the hegemonic behavior of doctors deprived nurses their right participate in multidisciplinary team activities. The aim is demonstrate and promote key skills reflection, while also developing critical awareness analysis potential problems arising from behaviour over nurses. Through application this reflective process, attempts are made break internal bondage reevaluate value...
The relationship between genetic alterations in mitochondrial DNA (mtDNA) and progressive motility (PR) rapid (grade A) of ejaculated human spermatozoa remains unclear. In this study, we explored the association mtDNA genotype sperm PR grade A by analyzing copy number, loci, haplogroup, rearrangement, deletions, duplications parameters. Human loci haplogroups were not associated with or grade. However, cumulative frequency rearrangements (including deletions duplications) participants high...